Stimulus Delivery and Response Hardware for fMRI Studies in Substance Abuse

用于药物滥用 fMRI 研究的刺激传递和响应硬件

• 批准号: 7490431
• 负责人: Dale E. Christopher
• 金额: $ 45.18万
• 依托单位: PSYCHOLOGY SOFTWARE TOOLS, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7490431
• 关键词: Addictive Behavior; Affect; Anxiety; Applications Grants; Attenuated; Award; Base of the Brain; Brain; Brain imaging; Businesses; Centers for Disease Control and Prevention (U.S.); Cigarette Smoker; Cognition; Complex; Computer software; Computers; Craniocerebral Trauma; Data; Development; Devices; Drug abuse; Emotions; Engineering; Environment; Equipment; Event; Exposure to; Family; Feedback; Fingers; Functional Imaging; Functional Magnetic Resonance Imaging; Future; Generations; Goals; Grant; Health; Human; Image; Immersion Investigative Technique; Income; Individual; Integrated Delivery Systems; Joystick; Link; Magnetic Resonance Imaging; Maps; Marketing; Modeling; Morphologic artifacts; Movement; National Institute of Drug Abuse; Noise; Odors; Peripheral; Pharmaceutical Preparations; Phase; Plague; Predisposition; Process; Psychology; Purpose; Recording of previous events; Recruitment Activity; Request for Proposals; Research; Research Design; Research Personnel; Sales; Sensory; Signal Transduction; Site; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Smoker; Smoking; Societies; Software Design; Software Tools; Solutions; Standards of Weights and Measures; Stimulus; Stream; Structure; Substance abuse problem; System; Tactile; Taste Perception; Techniques; Technology; Testing; Tongue; United States Food and Drug Administration; United States National Institutes of Health; Universities; Vision; Work; addiction; auditory stimulus; base; brain pathway; comparative; computerized; craving; drug of abuse; experience; grasp; improved; innovation; neuroimaging; novel strategies; programs; prototype; research and development; response; sensory stimulus; simulation; software development; tool; virtual; virtual reality

DESCRIPTION (provided by applicant): Addiction is a critical issue for our society and involves complex brain processes in which sensory stimulation and interaction with the environment are key factors for its understanding and treatment. This project proposes to develop a comprehensive family of hardware products for evoking intense sensory and experiential interaction during brain imaging studies. In particular the project will assess how the quality of the sensory experience and interaction affects brain pathways involved in craving and addiction. Specialized stimulation and control hardware will be engineered and used in fMRI studies to evaluate the added benefit of the technology. The effort involves integrating advanced technology for stimulus presentation, leading edge immersive VR technology, and fMRI based brain imaging. It will provide a comprehensive family of hardware products that can be used together or independently during fMRI studies and potentially during the course of drug abuse treatment efforts. The proposed fMRI peripheral hardware includes: 1) a stereo projector system to increase the sense of immersion; 2) an integrated dataglove with force and tactile feedback enabling grasping studies with virtual objects; 3) an odor delivery system capable of presenting multiple odors to a subject; 4) a taste delivery system capable of providing multiple tastes directly to the tongue; 5) an auditory stimulus delivery system with active noise cancellation to dramatically attenuate scanner noise; 6) a gamepad controller with joystick and buttons enabling control movement and responses during VR studies inside or outside of an MRI scanner. In addition to preliminary testing with subjects during fMRI studies of all the hardware to substantiate its effects, a comparative fMRI study with smokers will test the ability of the hardware to deliver sensory augmented VR simulations that are an improvement over the more traditional use of static images in craving studies. The business and marketing plan are conservative and based on the successful model Psychology Software Tools Inc (PST) has used in past niche market product development and marketing. The staff includes leaders in computerized experimentation, brain imaging and fMRI addiction research who have a history of working with university researchers to provide market leading technology in experimental control (E- Prime is used by over 10,000 researchers) and functional imaging systems (IFIS is installed at over 200 MRI sites). The business plan builds on the past track record that has resulted in every SBIR phase II research program being transitioned into a market leading technology with over three million dollars of commercial sales within five years. Future research by many investigators would utilize the developed technology to advance understanding of brain processes involving addiction and cognition and provide a profitable income stream to continue innovation in the growing research interface of brain, cognition and addiction. This project will conduct the scientific research and development necessary to provide a comprehensive family of hardware products for effectively and reliably evoking intense sensory and experimental interaction during fMRI brain imaging. Future scientific research efforts made possible or furthered by the availability of these tools will advance the understanding of the brain processes related to addictive behavior and cognition. This understanding will be used to assess and treat key societal substance abuse problems which have become a plague upon the health of our nation, affecting millions of individuals and defying current solutions.

描述（由申请人提供）：成瘾是我们社会的一个关键问题，涉及复杂的大脑过程，其中感官刺激和与环境的相互作用是理解和治疗成瘾的关键因素。该项目计划开发一个综合的硬件产品系列，用于在脑成像研究过程中激发强烈的感官和体验交互。特别是，该项目将评估感官体验和互动的质量如何影响涉及渴望和成瘾的大脑通路。专门的刺激和控制硬件将被设计并用于功能磁共振成像研究，以评估该技术的额外优势。这项工作涉及整合先进的刺激呈现技术、领先的沉浸式 VR 技术和基于功能磁共振成像的大脑成像。它将提供一个全面的硬件产品系列，可以在功能磁共振成像研究期间以及可能在药物滥用治疗过程中一起或独立使用。所提出的功能磁共振成像外围硬件包括：1）立体投影系统，以增加沉浸感； 2) 具有力和触觉反馈的集成数据手套，可实现虚拟物体的抓取研究； 3)能够向受试者呈现多种气味的气味传送系统； 4) 能够直接向舌头提供多种味道的味道输送系统； 5) 具有主动噪声消除功能的听觉刺激传递系统，可显着减弱扫描仪噪声； 6) 带有操纵杆和按钮的游戏手柄控制器，可在 MRI 扫描仪内部或外部的 VR 研究期间控制移动和响应。除了在对所有硬件进行 fMRI 研究期间对受试者进行初步测试以证实其效果之外，对吸烟者进行的比较 fMRI 研究还将测试硬件提供感官增强 VR 模拟的能力，这比在烟瘾研究中更传统地使用静态图像有所改进。业务和营销计划是保守的，并且基于 Psychology Software Tools Inc (PST) 在过去的利基市场产品开发和营销中使用的成功模式。员工包括计算机化实验、脑成像和功能磁共振成瘾研究领域的领导者，他们曾与大学研究人员合作，提供实验控制（超过 10,000 名研究人员使用 E-Prime）和功能成像系统（IFIS 安装在 200 多个 MRI 站点）方面的市场领先技术。该业务计划建立在过去的记录之上，该记录使每个 SBIR 第二阶段研究项目都在五年内转变为市场领先技术，商业销售额超过 300 万美元。许多研究人员未来的研究将利用已开发的技术来促进对涉及成瘾和认知的大脑过程的理解，并提供有利可图的收入来源，以在不断发展的大脑、认知和成瘾研究界面中继续创新。该项目将进行必要的科学研究和开发，以提供全面的硬件产品系列，以便在功能磁共振成像脑成像过程中有效、可靠地引发强烈的感官和实验交互。这些工具的可用性使未来的科学研究工作成为可能或进一步推进，将促进对与成瘾行为和认知相关的大脑过程的理解。这种理解将用于评估和治疗关键的社会药物滥用问题，这些问题已成为我们国家健康的瘟疫，影响了数百万人，并且无视当前的解决方案。