Mesenchymal Vascular Progenitor Depletion Promotes Lung Aging and Susceptibility to Emphysema

间充质血管祖细胞耗竭促进肺衰老和肺气肿易感性

基本信息

  • 批准号:
    10542770
  • 负责人:
  • 金额:
    $ 99.6万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-01-01 至 2028-12-31
  • 项目状态:
    未结题

项目摘要

The overall mission of this research program is to define how pulmonary Mesenchymal Vascular Progenitor Depletion Promotes Lung Aging and Susceptibility to Emphysema. Loss of epithelial progenitor cell function is a unifying factor in accelerated lung aging, and the development of emphysema. However, equally as important but poorly understood, there is a gap in our understanding of mesenchymal vascular progenitors (MVPC) in these processes. This proposal is significant as it attempts to fill in a number of important gaps surrounding how dysfunction of the MVPC progenitor population, contributes to aging and increased susceptibility to emphysema via regulation of vascular remodeling and loss of angiostasis. Analysis of the MVPC - lung niche interactions provide a target rich environment to identify nuances in MVPC progenitor dependent pathways relevant to the pathobiology of Angiostasis, Aging and Emphysema, as well as the potential to identify therapeutics to restore tissue function. We propose three focus areas for our research based on complementary themes. Theme 1 Regulation of MVPC function in healthy and aged lung: we will use our unique in vivo and in vitro model systems to identify how MVPC function and adaptive angiogenesis is regulated during tissue homeostasis and aging. Theme 2 Consequence of MVPC Loss of Function in healthy, aged and cigarette smoke exposed lung: we will show that loss of MVPC function, by depletion or altered signaling, drives vasculopathy and subsequent lung aging and emphysema. Theme 3 Therapeutic Rescue of MVPC function in aged and cigarette smoke exposed lung: we will validate the use of MVPC and repurposing of FDA approved paquinimod to restore MVPC numbers and function, subsequent tissue function and establish time frames for intervention. Positive results from these studies are readily translatable. We will leverage our strong collaborations, at National Jewish, University of Colorado as well as internationally recognized collaborators provide a basic and translational understanding of the mechanisms regulating MVPC function and differentiation at the single cell level as well as how they regulate their niche and lung microenvironment. We will also define whether progenitor rescue with MVPC cell therapy or interventional treatment will restore lung structure and function.
The overall mission of this research program is to define how pulmonary Mesenchymal Vascular Progenitor Depletion Promotes Lung Aging and Susceptibility to Emphysema. Loss of epithelial progenitor cell function is a unifying factor in accelerated lung aging, and the development of emphysema. However, equally as important but poorly understood, there is a gap in our understanding of mesenchymal vascular progenitors (MVPC) in these processes. This proposal is significant as it attempts to fill in a number of important gaps surrounding how dysfunction of the MVPC progenitor population, contributes to aging and increased susceptibility to emphysema via regulation of vascular remodeling and loss of angiostasis. Analysis of the MVPC - lung niche interactions provide a target rich environment to identify nuances in MVPC progenitor dependent pathways relevant to the pathobiology of Angiostasis, Aging and Emphysema, as well as the potential to identify therapeutics to restore tissue function. We propose three focus areas for our research based on complementary themes. Theme 1 Regulation of MVPC function in healthy and aged lung: we will use our unique in vivo and in vitro model systems to identify how MVPC function and adaptive angiogenesis is regulated during tissue homeostasis and aging. Theme 2 Consequence of MVPC Loss of Function in healthy, aged and cigarette smoke exposed lung: we will show that loss of MVPC function, by depletion or altered signaling, drives vasculopathy and subsequent lung aging and emphysema. Theme 3 Therapeutic Rescue of MVPC function in aged and cigarette smoke exposed lung: we will validate the use of MVPC and repurposing of FDA approved paquinimod to restore MVPC numbers and function, subsequent tissue function and establish time frames for intervention. Positive results from these studies are readily translatable. We will leverage our strong collaborations, at National Jewish, University of Colorado as well as internationally recognized collaborators provide a basic and translational understanding of the mechanisms regulating MVPC function and differentiation at the single cell level as well as how they regulate their niche and lung microenvironment. We will also define whether progenitor rescue with MVPC cell therapy or interventional treatment will restore lung structure and function.

项目成果

期刊论文数量(0)
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SUSAN M MAJKA其他文献

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{{ truncateString('SUSAN M MAJKA', 18)}}的其他基金

Loss of progenitor function accelerates lung aging
祖细胞功能丧失加速肺部衰老
  • 批准号:
    10579157
  • 财政年份:
    2023
  • 资助金额:
    $ 99.6万
  • 项目类别:
Mesenchymal Vascular Progenitor Depletion Promotes Lung Aging and Susceptibility to Emphysema
间充质血管祖细胞耗竭促进肺衰老和肺气肿易感性
  • 批准号:
    10353622
  • 财政年份:
    2022
  • 资助金额:
    $ 99.6万
  • 项目类别:
Loss of progenitor function accelerates lung aging
祖细胞功能丧失加速肺部衰老
  • 批准号:
    10426410
  • 财政年份:
    2021
  • 资助金额:
    $ 99.6万
  • 项目类别:
Role of Lung MSC in Emphysema
肺间充质干细胞在肺气肿中的作用
  • 批准号:
    10153854
  • 财政年份:
    2019
  • 资助金额:
    $ 99.6万
  • 项目类别:
Role of Lung MSC in Emphysema
肺间充质干细胞在肺气肿中的作用
  • 批准号:
    9705978
  • 财政年份:
    2019
  • 资助金额:
    $ 99.6万
  • 项目类别:
Role of Lung MSC in Emphysema
肺间充质干细胞在肺气肿中的作用
  • 批准号:
    9898030
  • 财政年份:
    2019
  • 资助金额:
    $ 99.6万
  • 项目类别:
Role of Lung MSC in Emphysema
肺间充质干细胞在肺气肿中的作用
  • 批准号:
    8848878
  • 财政年份:
    2013
  • 资助金额:
    $ 99.6万
  • 项目类别:
Role of Lung MSC in Emphysema
肺间充质干细胞在肺气肿中的作用
  • 批准号:
    8599945
  • 财政年份:
    2013
  • 资助金额:
    $ 99.6万
  • 项目类别:
Role of Lung MSC in Emphysema
肺间充质干细胞在肺气肿中的作用
  • 批准号:
    8704827
  • 财政年份:
    2013
  • 资助金额:
    $ 99.6万
  • 项目类别:
Induced pluripotent stem cell therapy for lipodystrophy
诱导多能干细胞治疗脂肪营养不良
  • 批准号:
    8542832
  • 财政年份:
    2012
  • 资助金额:
    $ 99.6万
  • 项目类别:

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