Cell type specific vulnerability to aging
细胞类型特定的衰老脆弱性
基本信息
- 批准号:10737185
- 负责人:
- 金额:$ 243.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AdultAffectAgeAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease modelAlzheimer&aposs disease riskAnimalsAuditoryAuditory areaAuditory systemBar CodesBehaviorBehavioralBrainCDH23 geneCell NucleusCellsCentral Auditory DiseasesCentral Nervous SystemCommunicationDataDementiaDisease ProgressionFunctional disorderGene ExpressionGenetic TranscriptionGoalsHearingHearing problemHumanImageImpaired cognitionInterventionKnowledgeLinkMeasurementModalityMolecularMolecular ProfilingMultiplexed Analysis of Projections by SequencingMusNeuronsPeripheralPhysiologicalPresbycusisPrevention strategyProceduresProcessPublic HealthResolutionRiskRoleSeriesSocial isolationSocietiesTestingTherapeuticTrainingWorkage relatedagedauditory pathwaycell typecognitive functionexperimental studygene functionhearing impairmenthuman diseasein situ sequencingin vivolife-long learningmild cognitive impairmentmultimodalityneuroimagingnext generationnormal agingpreventtau Proteinstranscriptome sequencingtranscriptomicstranslational potentialtwo-photon
项目摘要
Project Summary: Cognitive decline is an already significant and increasing public health issue.
Multiple factors contribute to cognitive decline. In particular, hearing is central to human
communication and age-related hearing loss (ARHL, presbycusis) by itself is a common ailment
due to age-related changes along the auditory pathway. Both hearing loss and aging are
associated with cognitive decline, increasing the risk for Alzheimer's disease (AD). In many
cases of presbycusis peripheral function is normal, pointing to a large role of central auditory
system dysfunctions. However, the age-related changes in the central nervous system that
underlie these functional deficits are largely unknown due to the functional and molecular
complexity of central circuits. This lack of knowledge precludes targeted interventions. We
hypothesize that the key changes in normal aging and AD in the central nervous system is the
dedifferentiation of neurons, that is the loss of their functional, transcriptional, and connectional
identities, and that this dedifferentiation occurs more rapidly in AD.
We test this hypothesis by a series of molecular and cellular neuro-imaging experiments
in both aged animals and an AD model, which explores the molecular, connectomic, and
physiological correlates of ARHL and identifies precisely which auditory cortical circuits are
impacted by aging. Based on preliminary data showing that lifelong auditory training can prevent
at least some of the age-related changes in A1, we then develop therapeutic strategies through
plasticity induced by engagement of cognitive functions. To achieve our goals, we integrate at
the level of single cells across large scale single-nucleus RNAseq, spatially resolved STARmap
in situ sequencing, next-generation barcode-based connectomics, and in vivo 2-photon imaging.
We also use training procedures to reverse some of the age-related changes.
项目摘要:认知能力下降已经是一个重要的、日益严重的公共卫生问题。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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PATRICK O KANOLD其他文献
PATRICK O KANOLD的其他文献
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{{ truncateString('PATRICK O KANOLD', 18)}}的其他基金
HIGH THROUGHPUT HOME CAGE PLATFORMS FOR INVESTIGATING NEUROPSYCHIATRIC DISORDERS IN MICE
用于研究小鼠神经精神疾病的高通量家用笼式平台
- 批准号:
10325608 - 财政年份:2021
- 资助金额:
$ 243.39万 - 项目类别:
Cross-modal enhancement of auditory plasticity and performance in adults
跨模式增强成人听觉可塑性和表现
- 批准号:
10203918 - 财政年份:2020
- 资助金额:
$ 243.39万 - 项目类别:
Cross-modal enhancement of auditory plasticity and performance in adults
跨模式增强成人听觉可塑性和表现
- 批准号:
10668548 - 财政年份:2020
- 资助金额:
$ 243.39万 - 项目类别:
Cross-modal enhancement of auditory plasticity and performance in adults
跨模式增强成人听觉可塑性和表现
- 批准号:
10589190 - 财政年份:2020
- 资助金额:
$ 243.39万 - 项目类别:
Cross-modal enhancement of auditory plasticity and performance in adults
跨模式增强成人听觉可塑性和表现
- 批准号:
10748930 - 财政年份:2020
- 资助金额:
$ 243.39万 - 项目类别:
Cross-modal enhancement of auditory plasticity and performance in adults
跨模式增强成人听觉可塑性和表现
- 批准号:
10028097 - 财政年份:2020
- 资助金额:
$ 243.39万 - 项目类别:
Cross-modal enhancement of auditory plasticity and performance in adults
跨模式增强成人听觉可塑性和表现
- 批准号:
10667562 - 财政年份:2020
- 资助金额:
$ 243.39万 - 项目类别:
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