Emotion-Regulation, Inflammatory Processes, and Depression in Prostate Cancer Sur

前列腺癌的情绪调节、炎症过程和抑郁

• 批准号: 8630215
• 负责人: Michael A Hoyt
• 金额: $ 38.54万
• 依托单位: HUNTER COLLEGE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8630215
• 关键词: Aftercare; American; Area; Awareness; Behavior; Biological; Blood specimen; Cancer Center; Cancer Patient; Clinic; Communities; Depressive disorder; Development; Diagnosis; Diagnostic; Disease; Emotional; Emotions; Epidemiologic Studies; Evaluation; Goals; Grant; Health; Heterogeneity; Incidence; Inflammatory; Interleukin-6; Intervention; Interview; Malignant Neoplasms; Malignant neoplasm of prostate; Masculine; Measures; Mediating; Mediator of activation protein; Mental Depression; Nature; Neurotic Disorders; New York; New York City; Operative Surgical Procedures; Outcome; Patients; Pattern; Physical Function; Plasma; Process; Prostate; Psychological Models; Psychological adjustment; Psychoneuroimmunology; Publishing; Questionnaires; Radiation therapy; Radical Prostatectomy; Recording of previous events; Recruitment Activity; Research; Research Design; Risk; Shapes; Social support; Stress and Coping; Structure; Testing; Time; To specify; Treatment Efficacy; Writing; cancer therapy; critical period; cytokine; depressive symptoms; emotion regulation; experience; men; psychologic; sample collection; showing emotion; social; stressor; theories

DESCRIPTION (provided by applicant): In the approximately 2.5 million American men diagnosed, the experience of prostate cancer can exact a psychological and physical toll. The period following radical prostatectomy or radiation therapy for localized prostate cancer is marked by relatively rapid changes physical functioning and can be a critical period marked by increased depression and poor psychological adjustment for men. In the context of cancer, depression can compromise important health outcomes. However, little research has sought to examine the unfolding risk and occurrence of depression following prostate cancer treatment. A primary goal of this research is to specify and test a theoretically-driven model of how psychological and contextual vulnerabilities shape trajectories of depression in the year following prostate cancer treatment. This project calls upon stress and coping, psychoneuroimmunology, and emotion regulation theories and research to investigate the causes and mechanisms of depression among prostate cancer patients. This research seeks to accomplish three specific aims. Aim 1 is to investigate how psychological and contextual vulnerabilities (including cancer-related and general stressors), emotion-regulating processes, and proinflammatory cytokines shape trajectories of depression in men with prostate cancer in the year following treatment. Aims 2 and 3 will examine emotion regulating processes and proinflammatory markers as proximal mediators of psychological and contextual vulnerabilities' effects on depression, respectively. We will accomplish these aims using a longitudinal research design set to begin prior to initiation of cancer treatment in 150 ethnically-diverse men, with subsequent assessments at 1 and 2 months post-treatment, and every 2 subsequent months through month 12. Blood sample collection, validated questionnaires and interviews, and evaluations of emotionally-expressive behaviors will be administered. This approach will allow for identification of which features characterize patients in whom depression is persistent and to whom to target intervention. Understanding the patterns and etiologic processes of depression as it is experienced by prostate cancer patients will have implications for the assessment and treatment of depression and the development of efficacious interventions

描述（由申请人提供）：在大约250万被诊断的美国男性中，前列腺癌的经历可能会造成心理和身体上的损失。根治性前列腺切除术或局部前列腺癌放射治疗后的时期，其特征是身体功能的变化相对较快，并且可能是一个关键时期，其特征是男性抑郁症增加和心理适应不良。在癌症的背景下，抑郁症可以损害重要的健康结果。然而，很少有研究试图检查前列腺癌治疗后抑郁症的风险和发生。这项研究的主要目标是指定和测试一个理论驱动的模型，该模型旨在研究心理和背景脆弱性如何在前列腺癌治疗后的一年中塑造抑郁症的轨迹。本计画以压力与因应、心理神经免疫学、情绪调节等理论与研究，探讨前列腺癌病患忧郁的成因与机制。本研究旨在实现三个具体目标。目的1是研究心理和环境脆弱性（包括癌症相关和一般压力源），情绪调节过程和促炎细胞因子如何在治疗后一年内塑造前列腺癌男性抑郁症的轨迹。目的2和3将分别研究情绪调节过程和促炎标记物作为心理和情境脆弱性对抑郁影响的近端介质。我们将使用纵向研究设计来实现这些目标，该设计设置为在150名不同种族的男性中开始癌症治疗之前开始，随后在治疗后1个月和2个月进行评估，并在随后的2个月至12个月进行评估。将进行血液样本采集、有效问卷调查和访谈，以及情感表达行为的评估。这种方法将允许识别哪些特征表征抑郁症持续存在的患者以及针对哪些患者进行干预。了解前列腺癌患者所经历的抑郁症的模式和病因过程将对抑郁症的评估和治疗以及有效干预措施的发展产生影响