Effective Network to advance Scientific Evidence related to Mechanisms of music-Based interventions (ENSEMBLE)

项目总结/摘要 疼痛是一个公共卫生问题，是寻求医疗保健和药物使用的主要驱动力，是导致 这是残疾的一个重要因素，也是影响生活质量和生产力的一个关键因素。基于音乐的干预措施（MBIs），包括 音乐疗法（MT）被认为对几个人群的疼痛管理有效。然而， 在理解作用机制方面仍然存在差距（例如，认知、基因组学、代谢组学和神经学） MBIs影响疼痛的机制推进这一机制性研究的障碍包括：1）缺乏 音乐治疗师和机械科学家之间有意义和包容性的合作; 2）不一致 MBI的应用和定义、患者报告的结局和生物学指标;以及3）缺乏资金 以及支持跨学科试点项目的基础设施。 该提案旨在建立一个新的合作网络：促进科学发展的有效网络 与基于音乐的疼痛干预机制相关的证据，并支持合作努力 （ENSEMBLE）推进合作研究工作，调查MBIs影响的机制 各种疼痛表型。ENSEMBLE将建立在良好整合的医疗MT实践基础上， 综合健康和医学（IHM）的机械科学，研究MT和生物 SCD疼痛机制和BraveNet基于实践的研究网络。首先，SCD将服务于 鉴于ENSEMBLE团队成员目前的专业知识， 初步数据，但其他疼痛条件将在未来几年解决。 ENSEMBLE将由克利夫兰大学医院/凯斯西储大学医院的研究人员领导 大学、加州尔湾大学、路易斯·阿姆斯特朗音乐与医学中心、伊坎学院 西奈山医学院和埃默里大学。ENSEMBLE将建立一个充满活力的合作网络， 音乐治疗师、机械科学家、音乐干预研究人员、IHM研究人员和患者倡导者 组织的 具体目标是：（1）促进有意义的，包容性的和跨学科的合作， 音乐治疗师，机械科学家和IHM研究人员;（2）制定一个全面的框架， 开展MBIs疼痛管理机制研究;（3）推进多个试点项目 研究MBI对各种疼痛表型的作用的新生物学机制。 ENSEMBLE的影响将有助于1）促进有意义的跨学科对话; 2） 建立多机构能力，启动疼痛管理的MBI研究; 3）产生初步的 未来R21或R34资助提案的数据; 4）改善数据基础设施; 5）开发未来的MT临床医生 研究人员; 6）集中未来的科学努力;和7）传播最佳做法。

PROJECT SUMMARY/ABSTRACT Pain is a public health problem, a major driver of health care seeking and medication use, a major cause of disability, and a key factor affecting quality of life and productivity. Music-based interventions (MBIs) including music therapy (MT) are known to be effective for managing pain in several populations. However, substantial gaps remain in understanding the mechanisms of action (e.g., cognitive, genomic, metabolomic, and neurologic) by which MBIs influence pain. Barriers to advancing this mechanistic r esearch have included: 1) lack of meaningful and inclusive collaboration between music therapists and mechanistic scientists; 2) inconsistent application and definition of MBIs, patient-reported outcomes, and biological measures; and 3) lack of funding and infrastructure to support interdisciplinary pilot projects. This proposal seeks to establish a NEW collaborative network: Effective Network to advance Scientific Evidence related to Mechanisms of music-Based interventions for pain and support coLlaborative Efforts (ENSEMBLE) to advance collaborative research efforts investigating the mechanisms by which MBIs influence various pain phenotypes. ENSEMBLE will be built on a foundation of well-integrated medical MT practice, strong mechanistic science in integrative health and medicine (IHM), research investigating MT and biological mechanisms of pain in SCD and the BraveNet Practice-Based Research Network. At the outset, SCD will serve as the pain-related condition of interest given the expertise of ENSEMBLE team members at present and strong preliminary data, but other pain conditions will be addressed in future years. ENSEMBLE will be led by investigators from University Hospitals of Cleveland/Case Western Reserve University, University of California Irvine, The Louis Armstrong Center for Music & Medicine, Icahn School of Medicine at Mount Sinai, and Emory University. ENSEMBLE will establish a vibrant collaborative network of music therapists, mechanistic scientists, music intervention researchers, IHM resear chers, and patient-advocacy organizations. The Specific Aims are to: (1) promote meaningful, inclusive, and interdisciplinary collaboration between music therapists, mechanistic scientists, and IHM researchers; (2) develop a comprehensive framework for conducting mechanistic studies in MBIs for pain management; and (3) advance multiple pilot projects investigating novel biological mechanisms of action underlying the effects of MBIs for various pain phenotypes. The IMPACT of ENSEMBLE will be instrumental in 1) promoting meaningful interdisciplinary dialogue; 2) building multi-institutional capacity for initiating MBI research in pain management; 3) generating preliminary data for future R21 or R34 grant proposals; 4) improving data infrastructure; 5) developing future MT clinician researchers; 6) focusing future scientific efforts; and 7) disseminating best practices.