Training Grant in Precision Cancer Control

精准癌症控制培训补助金

• 批准号: 10768785
• 负责人: Carolyn Y. Fang
• 金额: $ 15.59万
• 依托单位: RESEARCH INST OF FOX CHASE CAN CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-14 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10768785
• 关键词: Cancer Control; Grant; Training

PROJECT SUMMARY In the United States, more than 40 percent of new cancer cases can be attributed to modifiable factors. Yet, despite advances in knowledge regarding the multilevel factors associated with cancer risk, the annual number of cancer cases is predicted to increase nearly 50%, from 1.5 million new cases in 2015 to approximately 2.3 million in 2050. Thus, a greater emphasis on cancer risk reduction and cancer control – along with a highly trained workforce in this domain -- is needed to counter this projected increase. Recent advances in precision medicine have resulted in great optimism for potential therapeutic options and may provide a ‘model’ for how to evolve the field of cancer control. To realize the full potential of precision cancer control, it will be imperative to not only assess biologic properties, but to also consider individual variabilities in behavioral, lifestyle, and environmental factors. As a result, precision cancer control research requires multidisciplinary approaches that enable seamless integration and collaboration to inform our understanding of how to identify those individuals who are at elevated risk or who might benefit from specific, effective, and implementable interventions. Thus, there is a significant need to equip the next generation of cancer control scientists with skills required to: (1) precisely characterize the populations at increased risk for cancer or poor outcomes; (2) identify the multilevel factors contributing to elevated risk or negative outcomes; and (3) develop and implement appropriate interventions to effectively address those factors. This application for a new T32 postdoctoral training program at Fox Chase Cancer Center is designed to prepare PhD and MD postdoctoral fellows to conduct innovative research in precision cancer control with diverse populations. The transdisciplinary training includes a complementary program of didactic activities and intensive mentored research experiences, which will equip trainees to lead independent careers in precision cancer control. The Program Faculty include 25 mentors, all of whom have established track records of obtaining peer-reviewed funding. We propose to enroll 2 postdoctoral fellows each year (for two-year terms) over the five-year award. All fellows will receive rigorous training in the principles of precision cancer control, research design and methodology, grant-writing, responsible conduct of research, and career/professional skills development. T32 mentors are drawn from a broad base of exceptional Cancer Center faculty with a breadth of expertise ranging from molecular biology, genetics, epidemiology, biostatistics, geospatial technology, psychology, public health, and implementation science. The rich resources available at Fox Chase Cancer Center (FCCC) include comprehensive genomic, biologic, sociocultural, behavioral, and environmental-level data combined with advanced geospatial and statistical tools that will enable our faculty and their trainees to apply precision cancer control methods in strategic efforts toward reducing cancer risk and mortality across diverse populations.

项目摘要 在美国，超过40%的新发癌症病例可归因于可改变的因素。然而， 尽管在与癌症风险相关的多层次因素的知识方面取得了进展， 预计癌症病例将增加近50%，从2015年的150万新发病例增加到约2.3%。 2050年的百万。因此，更加重视癌症风险的降低和癌症控制--沿着高度重视 需要这一领域训练有素的工作人员来应对这一预计的增长。精度方面的最新进展 医学已经为潜在的治疗选择带来了极大的乐观，并可能为如何 发展癌症控制领域。为了充分发挥精准癌症控制的潜力， 不仅要评估生物学特性，还要考虑行为、生活方式和 环境因素因此，精确的癌症控制研究需要多学科的方法， 实现无缝集成和协作，使我们了解如何识别这些个人 风险较高或可能从具体、有效和可实施的干预措施中受益的人。因此，在本发明中， 迫切需要使下一代癌症控制科学家具备以下所需的技能：（1） 准确描述癌症风险增加或预后不良的人群;（2）确定多水平 导致风险升高或负面结果的因素;以及（3）制定和实施适当的 采取措施，有效解决这些问题。本次申请新增T32博士后培养计划 在福克斯大通癌症中心的目的是准备博士和医学博士博士后研究员进行创新 在不同人群中进行精确癌症控制的研究。跨学科培训包括 教学活动和密集的指导研究经验的补充计划，这将装备 学员在精准癌症控制方面独立工作。该计划教师包括25名导师，所有 他们已经建立了获得同行评审资金的跟踪记录。拟招收博士后2名 在五年的奖金中，每年都有研究员（任期两年）。所有研究员都将接受严格的培训， 精确癌症控制的原则，研究设计和方法，赠款写作，负责任的行为 研究和职业/专业技能发展。T32导师来自广泛的优秀基础， 癌症中心的教师具有广泛的专业知识，从分子生物学，遗传学，流行病学， 生物统计学、地理空间技术、心理学、公共卫生和实施科学。丰富的资源 可在福克斯大通癌症中心（FCCC）包括全面的基因组，生物，社会文化， 行为和环境层面的数据与先进的地理空间和统计工具相结合， 我们的教师和他们的学员在减少癌症的战略努力中应用精确的癌症控制方法 风险和死亡率。