Asian American Community Cohort and Equity Study (ACCESS)

亚裔美国人社区队列和公平研究 (ACCESS)

• 批准号: 10724846
• 负责人: Carolyn Y. Fang
• 金额: $ 62.66万
• 依托单位: RESEARCH INST OF FOX CHASE CAN CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724846
• 关键词: Address; Age; American; Asian; Asian Americans; Asian population; Behavioral; Biological; Biological Markers; Biomedical Research; Black Populations; Blood; Cambodian; Cardiometabolic Disease; Cardiovascular Diseases; Chinese; Chronic Disease; Cities; Clinic; Clinical; Cohort Studies; Collaborations; Collection; Communities; Complex; Data; Data Aggregation; Data Collection; Data Reporting; Diabetes Mellitus; Dietary Assessment; Dietary intake; Disparity; Enrollment; Epidemiology; Equity; Ethnic Origin; Filipino; Food; Goals; Growth; Hair; Health; Health Policy; Health behavior; High Prevalence; Hispanic Populations; Hypertension; Image; Incidence; Individual; Infrastructure; Intervention; Investigation; Koreans; Language; Longitudinal cohort study; Low Prevalence; Mediating; Methods; Mid-Atlantic Region; Minority; Modeling; Modification; Morbidity - disease rate; Nail plate; National Heart, Lung, and Blood Institute; Native Hawaiian or Other Pacific Islander; Nature; Neighborhoods; New Jersey; New York City; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obesity; Outcome; Parents; Participant; Pathway interactions; Patient Recruitments; Phase; Philadelphia; Pilot Projects; Population; Population Heterogeneity; Prevalence; Prevention Guidelines; Procedures; Productivity; Protocols documentation; Provider; Public Health Practice; Reporting; Research; Research Personnel; Resources; Risk; Risk Factors; Sampling; Sampling Studies; Secure; Standardization; Strategic vision; Structure of nail of toe; Subgroup; Urine; Vietnamese; Vulnerable Populations; Woman; Work; cardiometabolism; clinical examination; cohort; community organizations; community partnership; data repository; digital tool; disorder risk; experience; health difference; high risk; improved; lifestyle factors; member; men; mobile application; mortality; multidisciplinary; novel; outreach; participant retention; programs; prospective; psychosocial; racial population; recruit; retention rate; screening guidelines; social culture; social health determinants; socioeconomics; standardize measure

PROJECT SUMMARY Between 2000 and 2020, Asian Americans were the fastest growing racial group in the US, increasing from 10.5 million to 24 million individuals. By 2060, the number of US Asians is projected to rise to 46 million, more than triple their 2000 population. Although Asian Americans (AAs) are commonly viewed as a 'model minority' based on socioeconomic and health indicators, AAs actually have chronic disease rates that converge with or exceed those of US whites and are at higher risk for several cardiometabolic disorders despite having lower rates of obesity. However, due to limited data and the common practice of reporting aggregated data across multiple AA subgroups, the true extent and nature of the disparities that exist is not well understood. Thus, to address important gaps in the field, we propose to establish the Asian American Community Cohort and Equity Study (ACCESS) spanning across the greater Philadelphia-New Jersey-New York City region, which will include 2,400 men and women ages 25-64 drawn from 3 US Asian subgroups: Chinese (n=800), Vietnamese (n=800), and Filipino (n=800). Our multidisciplinary team will leverage our 22-year established PA-NJ-NYC Regional Network of collaborative community-based organization partners, clinical providers, city health departments, and academic investigators to support the cohort’s infrastructure and the recruitment of diverse research participants with respect to nativity, language, and generational status. With collaboration from our esteemed Community Advisory Board and Scientific Advisory Board members, our team has a strong and successful record of scientific productivity and expertise in: 1) the conduct of community-engaged longitudinal cohort studies with AA populations; 2) rigorous assessment of dietary intake and other health behaviors and lifestyle factors; 3) standardized measures of social determinants of health (SDoH) and neighborhood-level exposures; 4) collection of high-quality biospecimens for analysis of biologic markers; and 5) assessment of cardiometabolic outcomes (e.g., hypertension, type 2 diabetes, cardiovascular disease). The overall objectives of this application are to establish a rigorous infrastructure of ACCESS including formalizing clinical/community partnerships, developing cohort infrastructure, and establishing study protocols to support the standardized collection of comprehensive psychosocial, behavioral, and neighborhood-level data, along with biospecimens and other clinical exams. The proposed activities are closely aligned with NHLBI’s Strategic Vision and will address key research questions regarding how the prevalence of cardiometabolic disorders varies across Asian ethnic subpopulations, how SDoH relates to disease risk in specific subpopulations, and the identification of behavioral and biologic pathways that may account for individual or group differences in disease risk. This synergistic multidisciplinary plan to establish a prospective comprehensive cohort that includes 3 large AA subgroups will yield a rich resource to support rigorous research on multi-level pathways contributing to cardiometabolic disease risk and health outcomes in these large and growing, but understudied populations that experience significant disparities.

项目摘要 在2000年至2020年之间，亚裔美国人是美国增长最快的种族小组，从10.5增长 百万到2400万人。到2060年，美国亚洲人的数量预计将增加到4600万，超过 他们的2000人口三倍。尽管亚裔美国人（AAS）通常被视为基于“模型少数派” 关于社会经济和健康指标，AA的实际上具有慢性疾病率，其汇聚程度超过或超过 我们当中那些白人，尽管发生率较低，但患有多种心脏代谢疾病的风险 肥胖。但是，由于数据有限和报告跨多个AA的汇总数据的常见做法 亚组，存在的分布的真实程度和性质尚不清楚。那就解决了 该领域的重要差距，我们建议建立亚裔美国人社区队列和公平研究 （访问）跨越大费城 - 纽约州纽约市地区，其中包括2,400 来自3个美国亚洲亚组的男性和女性25-64岁：中文（n = 800），越南（n = 800）和 菲律宾（n = 800）。我们的多学科团队将利用我们22年已建立的PA-NJ-NYC区域网络 基于社区的合作组织合作伙伴，临床提供者，城市卫生部门和 学术研究人员支持队列的基础设施和招募不同的研究参与者 与我们尊敬的社区合作 顾问委员会和科学顾问委员会成员，我们的团队拥有科学的强烈而成功的记录 生产力和专业知识：1）通过AA进行社区参与的纵向队列研究的进行 人口； 2）严格评估饮食摄入量以及其他健康行为和生活方式因素； 3） 卫生社会决定者（SDOH）和邻里水平暴露的标准化度量； 4）收集 用于分析生物标记的高质量生物测量； 5）评估心脏代谢结果 （例如，高血压，2型糖尿病，心血管疾病）。此应用程序的总体目标是 建立严格的访问基础设施，包括格式化临床/社区合作伙伴关系，开发 队列基础架构，并建立研究方案，以支持标准化的全面收集 社会心理，行为和邻里级别的数据，以及生物测量和其他临床检查。这 拟议的活动与NHLBI的战略愿景密切相符，并将解决关键的研究问题 关于心脏代谢疾病的患病率如何在亚洲种族亚群中变化 SDOH与特定亚群中的疾病风险有关，并鉴定行为和生物学 可能解释疾病风险的个体或群体差异的途径。这种协同的多学科 计划建立一个预期的全面队列，其中包括3个大型AA子组将产生丰富的资源 支持对促成心脏代谢疾病风险和健康的多层途径的严格研究 在这些大型且成长中的结果中，但了解了经历了重大分布的人群。