Asian American Community Cohort and Equity Study (ACCESS)

亚裔美国人社区队列和公平研究 (ACCESS)

• 批准号: 10724846
• 负责人: Carolyn Y. Fang
• 金额: $ 62.66万
• 依托单位: RESEARCH INST OF FOX CHASE CAN CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724846
• 关键词: Address; Age; American; Asian; Asian Americans; Asian population; Behavioral; Biological; Biological Markers; Biomedical Research; Black Populations; Blood; Cambodian; Cardiometabolic Disease; Cardiovascular Diseases; Chinese; Chronic Disease; Cities; Clinic; Clinical; Cohort Studies; Collaborations; Collection; Communities; Complex; Data; Data Aggregation; Data Collection; Data Reporting; Diabetes Mellitus; Dietary Assessment; Dietary intake; Disparity; Enrollment; Epidemiology; Equity; Ethnic Origin; Filipino; Food; Goals; Growth; Hair; Health; Health Policy; Health behavior; High Prevalence; Hispanic Populations; Hypertension; Image; Incidence; Individual; Infrastructure; Intervention; Investigation; Koreans; Language; Longitudinal cohort study; Low Prevalence; Mediating; Methods; Mid-Atlantic Region; Minority; Modeling; Modification; Morbidity - disease rate; Nail plate; National Heart, Lung, and Blood Institute; Native Hawaiian or Other Pacific Islander; Nature; Neighborhoods; New Jersey; New York City; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obesity; Outcome; Parents; Participant; Pathway interactions; Patient Recruitments; Phase; Philadelphia; Pilot Projects; Population; Population Heterogeneity; Prevalence; Prevention Guidelines; Procedures; Productivity; Protocols documentation; Provider; Public Health Practice; Reporting; Research; Research Personnel; Resources; Risk; Risk Factors; Sampling; Sampling Studies; Secure; Standardization; Strategic vision; Structure of nail of toe; Subgroup; Urine; Vietnamese; Vulnerable Populations; Woman; Work; cardiometabolism; clinical examination; cohort; community organizations; community partnership; data repository; digital tool; disorder risk; experience; health difference; high risk; improved; lifestyle factors; member; men; mobile application; mortality; multidisciplinary; novel; outreach; participant retention; programs; prospective; psychosocial; racial population; recruit; retention rate; screening guidelines; social culture; social health determinants; socioeconomics; standardize measure

PROJECT SUMMARY Between 2000 and 2020, Asian Americans were the fastest growing racial group in the US, increasing from 10.5 million to 24 million individuals. By 2060, the number of US Asians is projected to rise to 46 million, more than triple their 2000 population. Although Asian Americans (AAs) are commonly viewed as a 'model minority' based on socioeconomic and health indicators, AAs actually have chronic disease rates that converge with or exceed those of US whites and are at higher risk for several cardiometabolic disorders despite having lower rates of obesity. However, due to limited data and the common practice of reporting aggregated data across multiple AA subgroups, the true extent and nature of the disparities that exist is not well understood. Thus, to address important gaps in the field, we propose to establish the Asian American Community Cohort and Equity Study (ACCESS) spanning across the greater Philadelphia-New Jersey-New York City region, which will include 2,400 men and women ages 25-64 drawn from 3 US Asian subgroups: Chinese (n=800), Vietnamese (n=800), and Filipino (n=800). Our multidisciplinary team will leverage our 22-year established PA-NJ-NYC Regional Network of collaborative community-based organization partners, clinical providers, city health departments, and academic investigators to support the cohort’s infrastructure and the recruitment of diverse research participants with respect to nativity, language, and generational status. With collaboration from our esteemed Community Advisory Board and Scientific Advisory Board members, our team has a strong and successful record of scientific productivity and expertise in: 1) the conduct of community-engaged longitudinal cohort studies with AA populations; 2) rigorous assessment of dietary intake and other health behaviors and lifestyle factors; 3) standardized measures of social determinants of health (SDoH) and neighborhood-level exposures; 4) collection of high-quality biospecimens for analysis of biologic markers; and 5) assessment of cardiometabolic outcomes (e.g., hypertension, type 2 diabetes, cardiovascular disease). The overall objectives of this application are to establish a rigorous infrastructure of ACCESS including formalizing clinical/community partnerships, developing cohort infrastructure, and establishing study protocols to support the standardized collection of comprehensive psychosocial, behavioral, and neighborhood-level data, along with biospecimens and other clinical exams. The proposed activities are closely aligned with NHLBI’s Strategic Vision and will address key research questions regarding how the prevalence of cardiometabolic disorders varies across Asian ethnic subpopulations, how SDoH relates to disease risk in specific subpopulations, and the identification of behavioral and biologic pathways that may account for individual or group differences in disease risk. This synergistic multidisciplinary plan to establish a prospective comprehensive cohort that includes 3 large AA subgroups will yield a rich resource to support rigorous research on multi-level pathways contributing to cardiometabolic disease risk and health outcomes in these large and growing, but understudied populations that experience significant disparities.

项目摘要 从2000年到2020年，亚裔美国人是美国增长最快的种族群体，从10.5 2400万至2400万人。到2060年，美国亚裔人口预计将增至4600万， 是2000年人口的三倍尽管亚裔美国人（AAs）通常被视为“模范少数族裔”， 在社会经济和健康指标上，AA实际上有慢性病发病率， 美国白人的心脏病发病率较高，尽管心脏病发病率较低， 肥胖然而，由于数据有限，以及报告多个AA汇总数据的常见做法， 在各分组中，人们对存在的差距的真实程度和性质并不十分了解。因此，为了解决 在该领域的重要差距，我们建议建立亚裔美国人社区队列和公平研究 （访问）跨越大费城-新泽西州-约克市地区，其中将包括2，400个 年龄25-64岁的男性和女性，来自3个美国亚裔亚组：中国人（n=800）、越南人（n=800）和 菲律宾人（n=800）。我们的多学科团队将利用我们22年建立的PA-NJ-NYC区域网络 合作的社区组织伙伴、临床提供者、城市卫生部门， 学术研究人员支持队列的基础设施和招募不同的研究参与者 关于出生，语言，和世代地位。与我们尊敬的社区合作 顾问委员会和科学顾问委员会成员，我们的团队拥有强大而成功的科学记录， 生产力和专业知识：1）与AA进行社区参与的纵向队列研究 人口; 2）严格评估饮食摄入量和其他健康行为和生活方式因素; 3） 健康的社会决定因素（SDoH）和社区水平暴露的标准化措施; 4）收集 高质量的生物样本，用于生物标志物分析; 5）心脏代谢结局评估 (e.g.,高血压、2型糖尿病、心血管疾病）。本申请的总体目标是 建立严格的ACCESS基础设施，包括正式建立临床/社区伙伴关系， 队列基础设施，并建立研究协议，以支持标准化的收集全面的 社会心理、行为和邻里水平的数据，沿着生物标本和其他临床检查。的 拟议的活动与NHLBI的战略远景密切相关，并将解决关键的研究问题 关于心脏代谢疾病的患病率在亚洲种族亚群中的差异， SDoH与特定亚群的疾病风险有关， 可能解释疾病风险的个体或群体差异的途径。这种协同的多学科 计划建立一个包括3个大型AA亚组的前瞻性综合队列将产生丰富的资源 支持对心脏代谢疾病风险和健康的多水平途径进行严格的研究 在这些庞大且不断增长但未得到充分研究的人口中取得成果，这些人口经历着巨大的差异。