Study to establish safety, tolerability and feasibility of LM11A-31 as a neuroprotective agent in aging people living with HIV and neurocognitive impairment on antiretroviral therapy

研究确定 LM11A-31 作为神经保护剂对老年艾滋病毒感染者和抗逆转录病毒治疗神经认知障碍患者的安全性、耐受性和可行性

• 批准号: 10762833
• 负责人: RICK B MEEKER
• 金额: $ 69.89万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10762833
• 关键词: AIDS clinical trial group; Adult; Adverse effects; Adverse event; Aftercare; Aging; Alzheimer' s disease pathology; Animal Model; Anti-Retroviral Agents; Attention; Behavior; Biological Assay; Biological Availability; Biological Markers; Blood; Brain; CD8-Positive T-Lymphocytes; CXCL10 gene; Calcium; Cell Count; Chronic; Cognitive; Cytoskeleton; DNA; Data; Disease; Disease Progression; Early identification; Enzyme-Linked Immunosorbent Assay; Equilibrium; Feline Immunodeficiency Virus; Felis catus; Foundations; Functional Magnetic Resonance Imaging; Gelatinase B; Goals; HIV; HIV Envelope Protein gp120; HIV Infections; HIV-associated neurocognitive disorder; Heterogeneity; Human; Immune; Impaired cognition; In Vitro; Individual; Infection; Inflammation; Inflammatory; Intervention; Ligands; Light; Macrophage; Magnetic Resonance Imaging; Maintenance; Measurement; Measures; Memory; Mental Health; Microglia; Motor; Mus; NGFR Protein; Nerve Degeneration; Neurocognitive; Neurocognitive Deficit; Neurodegenerative Disorders; Neuronal Dysfunction; Neurons; Neurophysiology - biologic function; Neuroprotective Agents; Neuropsychological Tests; Neuropsychology; Oral; Participant; Pathogenesis; Performance; Peripheral Blood Mononuclear Cell; Persons; Pharmaceutical Preparations; Phase; Plasma; Population; Process; RNA; Regenerative pathway; Regulation; Resources; Rest; Safety; Sampling; Signal Transduction; Structure; Swelling; TREM2 gene; Tablets; Test Result; Therapeutic; Transgenes; Transgenic Mice; Verbal Learning; Viral; Viremia; age related; antiretroviral therapy; anxiety reduction; blood-brain barrier crossing; cholinergic; chronic infection; cognitive function; cohort; cytokine; design; early detection biomarkers; effective therapy; efficacy evaluation; efficacy trial; executive function; follow-up; high risk; improved; indexing; inflammatory marker; mild neurocognitive impairment; nerve injury; nervous system infection; neural; neurofilament; neurogranin; neuroprotection; neuropsychiatry; neurotrophic factor; novel; novel marker; phase 1 study; pre-clinical; prevent; prevention efficacy trial; primary endpoint; processing speed; recruit; release factor; response to injury; targeted treatment; transcriptional coactivator p75; treatment duration; treatment response; trial design; verbal

Abstract HIV infection of the nervous system results in chronic infection, inflammation, neuropsychiatric problems and cognitive decline in up to 50% of people living with HIV with no effective treatments to-date. Inflammation appears early in the disease process and causes progressive neuronal damage due, in part, to factors released by activated microglia and macrophages. In cultured neurons and mice, expressing the HIV gp120 transgene these factors induce intracellular calcium accumulation, cytoskeletal damage and focal swelling, in a fashion similar to early Alzheimer’s disease (AD) pathology, suggesting a common substrate for disease progression. Age-dependent accumulation of the p75 neurotrophin receptor occurs early in disease and is thought to contribute to pathogenesis by shifting the balance of neurotrophin signaling away from protective, regenerative pathways. Treatment of aging and gp120 transgenic mice with a small non-peptide p75NTR ligand, LM11A-31, suppressed cholinergic degeneration, inflammation and neuronal damage. In cats chronically infected with feline immunodeficiency virus, ten weeks of oral treatment with LM11A-31 prevented degeneration, improved cognitive behaviors, reduced anxiety and CSF viral titers in the absence of any adverse effects on systemic viremia, PBMC FIV burden, or CD4:CD8 T cell ratios. Since p75NTR is normally expressed at very low levels in adult brain but is upregulated in response to injury or disease, it provides a unique target for therapy with minimal potential for off-target effects. The drug is orally bioavailable, crosses the blood brain barrier and has no significant adverse effects in humans at therapeutic concentrations. To explore the potential of LM11A-31 as a disease modifying neuroprotective treatment, the proposed studies will establish the safety and tolerability of LM11A-31 treatment in a small cohort of stable virally-suppressed participants with HIV and mild neurocognitive impairment. Safety measures will be supplemented with exploratory characterization of traditional and novel biomarkers for early detection of inflammation and neurodegeneration in CSF and blood. A novel fMRI Hcorr analysis will be used to provide a sensitive measure of early immune and p75NTR activation with the potential to identify individuals in early stages of neurodegeneration. Serial neuropsychological test results will provide preliminary data and facilitate transition to a subsequent efficacy trial for prevention of cognitive decline. These studies are expected to show that LM11A-31 is safe to use in people living with HIV and to lay the groundwork for a larger efficacy trial designed to demonstration protection from neuronal damage and cognitive decline.

摘要