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Admin Sup FACET: Family Dynamics and Child Neurodevelopment in Botswana

Admin Sup FACET: Family Dynamics and Child Neurodevelopment in Botswana
Admin Sup FACET:博茨瓦纳的家庭动态和儿童神经发育
批准号:
10766920
负责人:
Jennifer Jao
金额:
$28.77万
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-03-17 至 2025-06-30

项目摘要

项目成果

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中文摘要
翻译
在撒哈拉以南非洲(SSA),近1600万接触艾滋病毒但未感染的儿童中有90%生活在那里
英文摘要
In sub-Saharan Africa (SSA) is home to 90% of the nearly 16 million children who are HIV-exposed uninfected (CHEU). This population has been shown to be at increased risk of neurodevelopmental delays compared to their HIV-unexposed peers. The World Health Organization and UNICEF advocate for use of the Nurturing Care Framework, consisting of five facets of care – health, nutrition, responsive caregiving, safety from threats, and opportunities for learning – a framework shown to optimize child neurodevelopment when fully implemented. Given that families and caregivers are the primary source of a child's nurturing care, it is important to explore associations between family structures, home environment, and child neurodevelopment, particularly among families affected by HIV. In Botswana, a high prevalence HIV setting, one in four children under 15 years of age are CHEU, and fewer than 10% of parenting couples are formally married. Given the fact that the Nurturing Care Framework has never been programmatically implemented in Botswana and caregiving structures have not been well described, understand caregiving within this unique context of low marriage rates and high HIV prevalence and associations with developmental outcomes among CHEU is of critical public health importance. The proposed FACET study (Family Dynamics and Child Neurodevelopment in Botswana) will leverage an ongoing birth cohort within the FLOURISH Study (Following Longitudinal Outcomes to Understand, Report, Intervene and Sustain Health of Infants, Children and Adolescents who are HIV-Exposed Uninfected; R33 HD103099; Principal Investigators: Powis, Jao, Makhema) currently enrolling up to 300 pregnant persons, half of which are living with HIV, and their infants to a) (Aim 1) to characterize patterns of household composition and family dynamics for caregiving, and the role of nurturing care in promoting healthy neurodevelopment among children in Botswana using a focus group discussion format; and b) employing a mixed-methods design (Aim 2), assess the associations between child HIV exposure status, caregiver relationship factors, and child neurodevelopment. The Caregiver Reported Early Developmental Index (CREDI), a parent-reported assessment tool that has been validated for use across 26 countries, 17 of which are low-and-middle income countries, including Botswana, will be administered to FACET participating mothers when their child reaches six-months of life. Simultaneously, qualitative data will be collected from up to 30 mothers participating in a second round of focus group discussions exploring how their relationships with their partners, paternal involvement in caregiving, home environment factors (e.g., food insecurity, intimate partner violence), and child temperament may impact their caregiving. Convergent parallel triangulation will be employed to jointly interpret quantitative and qualitative research findings. Research is urgently needed to assess the combined impact of fetal HIV exposure and family structures on child neurodevelopment.
期刊论文(1)
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会议论文
DOI: 10.1002/jia2.26165
发表时间: 2023-10
期刊: Journal of the International AIDS Society
影响因子: 6
作者: []
通讯作者:
FLOURISH - Following Longitudinal Outcomes to Understand, Report, Intervene and Sustain Health for Infants, Children, Adolescent who are HIV Exposed Uninfected
  • 批准号:
    10064161
  • 项目类别:
  • 资助金额:
    $43.12万
  • 财政年份:
    2020
  • 负责人:
    Jennifer Jao
  • 依托单位:
Understanding Inflammatory and Metabolic Pathways of Myocardial and Vascular Dysfunction in South African Youth Living with Perinatal HIV
Understanding Inflammatory and Metabolic Pathways of Myocardial and Vascular Dysfunction in South African Youth Living with Perinatal HIV
FLOURISH - Following Longitudinal Outcomes to Understand, Report, Intervene and Sustain Health for Infants, Children, Adolescent who are HIV Exposed Uninfected
  • 批准号:
    10657825
  • 项目类别:
  • 资助金额:
    $61.28万
  • 财政年份:
    2020
  • 负责人:
    Jennifer Jao
  • 依托单位:
海外基金