2021 Neural Crest and Cranial Placodes GRC/GRS

2021 神经嵴和颅板 GRC/GRS

• 批准号: 10765885
• 负责人: Paul Trainor
• 金额: $ 0.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10765885
• 关键词: Acceleration; Achievement; Address; Adrenal Glands; Adult; Anterior Pituitary Gland; Biological Models; Biology; Biomedical Research; Cancer Biology; Cardiac; Cardiac Myocytes; Cartilage; Cells; Cephalic; Childhood Solid Neoplasm; Chromaffin Cells; Ciliary Muscle; Clinical; Collaborations; Communities; Congenital Abnormality; Congenital Disorders; Connective Tissue; Corneal Endothelium; Craniofacial Abnormalities; Data; Dedications; Defect; Development; Disease; Ectoderm; Education; Educational workshop; Embryonic Development; Endocrine; Enteral; Epithelium; Equilibrium; Evolution; Eye; Face; Feedback; Fertility; Fostering; Gender; Genomics; Goals; Head; Heart; Heart Septum; Homeostasis; Hour; Individual; International; Labyrinth; Malignant Neoplasms; Mentors; Mentorship; Mesenchymal; Modeling; Morphogenesis; Morphology; Neoplasm Metastasis; Neural Crest; Neural Crest Cell; Neuroglia; Neurons; Nose; Odontoblasts; Oral; Organ; Participant; Pathogenesis; Pattern; Peripheral; Physiological; Pigments; Population; Postdoctoral Fellow; Proteomics; Regenerative Medicine; Research; Research Personnel; Science; Scientist; Sense Organs; Sensory; Sensory Ganglia; Sensory Receptors; Skin; Supporting Cell; System; Systems Biology; Taste Buds; Technology; Time; Tissue Engineering; Tissues; Tooth structure; Trigeminal System; Underrepresented Minority; Visceral; Woman; Work; bone; career; career networking; cell type; disability; experience; gastrointestinal; graduate student; human stem cells; innovation; insight; lateral line; lens; meetings; migration; neoplastic cell; nerve supply; neural plate; neurodevelopment; neurotransmission; novel; novel strategies; peer; peer networks; posters; regenerative biology; somatosensory; stem cell biology; stem cells; supportive environment; symposium; technological innovation; transcriptomics

PROJECT SUMMARY Neural crest cells and cranial placodes share evolutionary and embryological origins and are of fundamental importance to vertebrate development, evolution and disease. Together, they form the cranial sensory ganglia, but individually they each give rise to an incredibly diverse array of cell types and tissues. Neural crest cells form most of the bone, cartilage and connective tissue of the head and face, the dentine-producing odontoblasts of teeth, the ciliary muscles and corneal endothelium of the eye, cardiomyocytes and aorticopulmonary septum of the heart, chromaffin cells in the adrenal gland, pigment cells in the skin, all peripheral glia, peripheral autonomic and enteric neurons, and most peripheral somatosensory neurons. Placodes form the sensory receptors, afferent innervation and support cells of the paired peripheral sense organs (nose, inner ear, lateral line system), the lenses of the paired eyes, cranial somatosensory (trigeminal) neurons and visceral sensory (epibranchial) neurons that transmit a wide variety of information from the heart, gut and other visceral organs, as well as taste buds, and the endocrine adenohypophysis which is important for fertility and homeostasis. Neural crest cells and cranial placodes provide experimental paradigms for studying cell and tissue induction, stem cell multipotency, patterning, morphogenesis, invagination, epithelial-mesenchymal transition, migration and differentiation. Neural crest cells and placodes are synonymous with vertebrate evolution, and defects in their development underlie a broad range of birth defects and diseases including craniofacial malformations, cardiac and gastrointestinal anomalies, sensory deficits, abnormal physiological function and cancer. This GRC and GRS on Neural Crest Cells and Cranial Placodes brings together a diverse group of leading scientists working on all aspects of neural crest cell and placode biology. The conference offers the chance to present unpublished data and novel approaches, form new collaborations, mentor junior scientists, and build professional networks in a supportive environment. The goals of the conference are to accelerate the exchange of interdisciplinary advances across different model systems, to promote technological innovations in the field, and deepen our understanding of neural crest cells and cranial placodes at genomic, transcriptomic and proteomic levels. Recent advances in generating neural crest cell and placode derivatives from human stem cells have major implications for our understanding of vertebrate development and evolution, the pathogenesis of congenital disorders and the promise of tissue engineering in regenerative medicine.

项目摘要 神经嵴细胞和颅基板共享进化和胚胎起源， 对脊椎动物发育、进化和疾病的重要性。它们共同组成了颅感觉神经节， 但它们各自产生了一系列令人难以置信的细胞类型和组织。神经嵴细胞 形成头面部的大部分骨骼、软骨和结缔组织， 牙齿的成牙本质细胞、眼睛的睫状肌和角膜内皮、心肌细胞和 心脏的肾上腺隔膜肾上腺的嗜铬细胞皮肤的色素细胞 外周神经胶质、外周自主神经元和肠神经元以及大多数外周躯体感觉神经元。 鳞片形成感觉感受器、传入神经支配和成对外周感觉的支持细胞 器官（鼻，内耳，侧线系统），成对眼睛的晶状体，颅体感（三叉神经） 神经元和内脏感觉（上鳃）神经元从心脏传递各种信息， 肠道和其他内脏器官，以及味蕾，以及内分泌腺垂体，这是重要的， 生育能力和体内平衡 神经嵴细胞和颅基板为研究细胞和组织诱导提供了实验范例， 干细胞多能性，模式化，形态发生，内陷，上皮-间质转化，迁移 和差异化。神经嵴细胞和基板是脊椎动物进化的同义词， 它们的发育是一系列出生缺陷和疾病的基础，包括颅面畸形， 心脏和胃肠道异常、感觉缺陷、生理功能异常和癌症。 这个关于神经嵴细胞和颅板的GRC和GRS汇集了一个不同的领导小组， 研究神经嵴细胞和基板生物学各个方面的科学家。会议提供了机会， 展示未发表的数据和新方法，形成新的合作，指导初级科学家，并建立 在支持性环境中的专业网络。会议的目标是加快 在不同的模型系统之间交流跨学科的进展，以促进技术创新， 该领域，并加深我们对神经嵴细胞和颅基板在基因组，转录组学， 和蛋白质组水平。人神经嵴细胞和基板细胞衍生物的研究进展 干细胞对我们理解脊椎动物的发育和进化有重要意义， 先天性疾病的发病机制和组织工程在再生医学中的前景。