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Network For Emotional Wellbeing And Brain Aging (NEW Brain Aging)

情绪健康和大脑老化网络（新大脑老化）

基本信息

批准号：
10762789
负责人：
YEATES CONWELL
金额：
$ 7.03万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-01 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10762789
关键词：
Address Adult Advisory Committees Aging Alzheimer&apos s disease related dementia Animal Model Animals Area Biological Markers Brain Brain imaging Cohort Studies Collaborations Consultations Data Dementia Development Educational workshop Elderly Emotional Ensure Evaluation Faculty Funding Future Gerontology Grant Growth Health Heterogeneity Human Interdisciplinary Study International Intervention Learning Literature Measurement Measures Mediating Mental Health Mentorship Methods Modeling Nature Neurosciences Outcome Paper Pathologic Peer Review Personal Satisfaction Pilot Projects Population Prevention strategy Process Productivity Protocols documentation Publishing Quality of life Regulation Reproducibility Research Research Methodology Research Personnel Research Project Grants Resources Risk Role Series Societies Stress Testing Time Universities Update Well in self aging brain biomarker identification brain based brain health brain research cohort density early detection biomarkers healthspan hedonic human model interest meetings neuroimaging neuropathology novel prevent repository resilience therapeutic target web site webinar

项目摘要

Project summary: Early evidence indicates an association between emotional (eudaimonic and hedonic) well- being (EWB) and underlying brain processes, and that those processes change with both normal and pathological brain aging. However, the nature of these associations, the mechanisms by which EWB and its component domains change with brain aging, and how those changes may be associated with common neuropathologies like Alzheimer’s disease and related dementias (ADRD), are largely unexplored. The objective of the Network for Emotional Well-being and Brain Aging (NEW Brain Aging) is to address priority area #2 – mechanistic research on the role of emotional well-being in health – of RFA-AT-20-003, identifying and testing mechanisms by which brain aging influences EWB and how EWB may impact risk for and progression of ADRD. Synthesizing human and animal literature, our premise is that relationships between EWB and ADRD are bidirectional – normal and pathological changes in aging brain influence EWB and EWB contributes to brain health and illness, such as ADRD. Further, we hypothesize that the relationships between EWB and the brain in older adults reflect aging-associated heterogeneity of brain (i.e., resilience, typical aging, or neuropathological changes), and that they are mediated by processes of appraisal and adaptation. To do so we will form a national, transdisciplinary collaborative that includes investigators representing research expertise in human and animal neuroimaging, stress regulation, ADRD research, EWB, and computational/quantitative methods. With direction of an Executive Committee and guided by an External Advisory Committee, NEW Brain Aging will undertake these specific aims: (1) To build an inter-university and transdisciplinary collaborative of senior and junior investigators interested in brain, aging, and EWB research from both human and animal fields; (2) To form a series of time-limited workgroups with relevant experts in the field, each working over 1-2 years, to establish priorities for NEW Brain Aging activities in each of three general areas: (a) brain mechanism research of EWB; (b) research of EWB’s impact on ADRD; and (c) translational animal and cross-species brain research methods; (3) To coalesce and coordinate resources to ensure the rigor and reproducibility of the brain-related EWB research; (4) To provide three types of pilot funding through rigorous peer review: (a) pilot research grants for junior faculty related to brain mechanism studies related to the relationship between EWB and dementia using human or animal models; (b) proof-of-concept grants for established investigators to test aspects related to EWB in their existing studies and cohorts of brain aging; (c) seed collaboration grants for cross-species brain research related to EWB; (5) To evaluate the network by tracking its activities, resource usage, and productivity, and conducting collaborative network density analysis throughout the 4-year grant; and (6) to ensure the wide dissemination of NEW Brain Aging products. By accomplishing these aims, we will strengthen a research network focusing on the brain mechanistic understanding of EWB and relationship between EWB and ADRD.

项目总结：早期的证据表明情绪（幸福和享乐）之间的联系