HEU outcomes: population-evaluation and screening strategies (HOPE)

HEU 结果：人群评估和筛查策略 (HOPE)

• 批准号: 10764153
• 负责人: Grace John-Stewart
• 金额: $ 29.84万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-07 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10764153
• 关键词: 2019-nCoV; 3 year old; Administrative Supplement; Adolescence; Adolescent; Advocate; Age; Anxiety; Attention deficit hyperactivity disorder; Biological Assay; Biological Markers; Blood; Budgets; Caregivers; Caring; Child; Childhood; Clinic; Collaborations; Communicable Diseases; Complement; Computerized Medical Record; Data; Development; Dryness; Early Intervention; Enrollment; Ethics; Evaluation; Family; Funding; Future; Goals; Growth; Guidelines; HIV; HIV-exposed uninfected infant; Hearing; Infant; Inflammation; Intervention; Kenya; Length; Longitudinal cohort; Measures; Mental Depression; Mental Health; Morbidity - disease rate; National Institute of Child Health and Human Development; Neurocognitive; Outcome; Parents; Perinatal; Phase; Policies; Population; Qualitative Methods; Qualitative Research; Regimen; Research Methodology; SARS-CoV-2 antibody; SARS-CoV-2 infection; Screening procedure; Site; Spottings; Structure; Testing; Viral Load result; Visual; Work; age stratification; antiretroviral therapy; caregiving; cofactor; cohort; cost estimate; design; efavirenz; falls; family influence; family structure; fetal; follow-up; human subject; improved; infancy; insight; mortality; neurodevelopment; parent grant; parental role; programs; psychosocial; screening; social culture; telomere; tool

Abstract Globally, the number of HIV-exposed uninfected (HEU) children/adolescents is growing, with 1.2 million HEU infants born annually1. There is evidence that HEU children have increased morbidity and mortality, and lower neurocognitive scores than their HIV-unexposed (HUU) counterparts. The parent HOPE study (NICHD R33103079) has been designed to compare neurodevelopmental outcomes between HEU and HUU children from 6-weeks of age to 3 years in a longitudinal cohort and to assess longer term effects in a multi-site cross- sectional age-stratified cohort. The HOPE study will assess influence of maternal viral load, ART timing, and regimen on HEU outcomes, and explore whether HEU neurodevelopmental outcomes are associated with telomere length (TL). Administrative Supplement: This supplement application falls within the scope of work of the parent application. The parent grant scope of work included assessment of cofactors that influence HEU/HUU neurodevelopmental outcomes including psychosocial, telomere length, and infectious diseases. In this Administrative Supplement proposal, we request funding for: • Goal 1. To characterize family structures and explore the roles of parental caregiving (including paternal perspectives) in child neurodevelopmental outcomes in HEU and HUU using participatory visual qualitative methods. Qualitative data will complement extensive quantitative data from the cohort of 1000 HEU and 1000 HUU in understanding how caregiver structure influences neurodevelopmental outcomes in both groups of children. • Goal 2. To conduct maternal telomere assays (parent budget supports infant telomere assays) and use this data to better characterize cofactors of infant telomere length (TL). Maternal TL assays [already approved by KNH and UW ethical committees] are a key predictor of infant TL). • Goal 3. To conduct SARS-CoV2 antibody testing [already approved by UW Human Subjects Division] on infant dried blood spots [DBS] already collected at 6 weeks and 1, 2, 3 years) to assess impact of maternal peripartum SARS-COV2 on already measured longitudinal infant neurodevelopmental outcomes. These goals leverage the unique HOPE cohort and enable more comprehensive assessment of critical determinants of child neurodevelopment.

抽象的 全球范围内，暴露于 HIV 的未感染儿童/青少年 (HEU) 数量不断增加，达到 120 万 HEU 每年出生的婴儿1.有证据表明，HEU 儿童的发病率和死亡率有所增加，并且发病率和死亡率较低 神经认知评分高于未暴露于 HIV 暴露者 (HUU) 的对应者。家长 HOPE 研究 (NICHD R33103079）旨在比较 HEU 和 HUU 儿童的神经发育结果 纵向队列中从 6 周龄到 3 岁的婴儿，并评估多地点交叉的长期影响 分段年龄分层队列。 HOPE 研究将评估母体病毒载量、ART 时机和 方案对 HEU 结果的影响，并探讨 HEU 神经发育结果是否与 端粒长度（TL）。 行政补充：本补充申请属于家长的工作范围 应用。家长资助的工作范围包括评估影响 HEU/HUU 的辅助因素 神经发育结果，包括心理社会、端粒长度和传染病。在这个 行政补充提案，我们请求资金用于： • 目标 1. 描述家庭结构的特征并探讨父母照顾的角色（包括父亲的照顾） 使用参与式视觉定性研究 HEU 和 HUU 儿童神经发育结果的观点） 方法。定性数据将补充来自 1000 个 HEU 和 1000 HUU 了解照顾者结构如何影响两者的神经发育结果 一群孩子。 • 目标 2. 进行母亲端粒测定（父母预算支持婴儿端粒测定）并使用此方法 数据以更好地表征婴儿端粒长度（TL）的辅助因子。母体 TL 检测 [已批准 由 KNH 和 UW 伦理委员会确定]是婴儿 TL 的关键预测因素）。 • 目标 3. 进行 SARS-CoV2 抗体检测 [已获得威斯康辛大学人类受试者部门批准] 婴儿干血斑 [DBS] 已在 6 周和 1、2、3 岁时收集，以评估母体的影响 围产期 SARS-COV2 对已测量的纵向婴儿神经发育结果的影响。 这些目标利用了独特的 HOPE 队列，能够对关键目标进行更全面的评估 儿童神经发育的决定因素。