Administrative Core

行政核心

• 批准号: 10381033
• 负责人: Grace John-Stewart
• 金额: $ 65.21万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-09 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10381033
• 关键词: Birth; Child; Child Health; Clinic; Collaborations; Communicable Diseases; Communication; Communities; County; Data; Data Analyses; Databases; Development; Ensure; Epidemiologist; Ethics; Exposure to; Grant; Gynecologist; HIV; HIV Infections; Head; Health; Hospitals; Human Resources; Immune; Institutional Review Boards; International; Kenya; Leadership; Link; Logistics; Maintenance; Measurement; Medical Research; Mentors; Mentorship; Office of Administrative Management; Online Systems; Outcome; Pediatrics; Performance; Pharmaceutical Preparations; Preparation; Principal Investigator; Procedures; Program Research Project Grants; Reporting; Research; Research Institute; Research Personnel; Research Project Grants; Resources; Seasons; Shipping; Site; Specialist; Standardization; Structure; Students; Training; Travel; Universities; Washington; Woman; Work; adolescent health; cohort; community engagement; dalton; data management; dissemination strategy; experience; insight; meetings; member; microbiome; pediatric human immunodeficiency virus; perinatal health; programs; research study; symposium; synergism; web site

The Administrative Core will provide scientific, administrative, mentorship, and logistical support to enable completion of the proposed P01 Program “Drug, microbiome, and immune determinants of birth and neurodevelopmental outcomes in children with exposure to HIV infection”. The Administrative Core will oversee centralized fiscal management, project coordination, regulatory activities, communications between the Projects and Cores in the Program, and mentorship, and dissemination strategies to engage community members and scientific community. Weekly progress on each of the 3 Projects will be shared within Projects; meetings summaries will be shared with the overall Program using a uniform reporting approach. A weekly Leadership Team (MPIs John-Stewart, Kinuthia, Wamalwa) meeting will include review of all Projects. An Executive Committee that includes all Project and Core Directors will meet monthly to review progress on Projects. Annually, an All-Team meeting of the P01 Program will be convened in Nairobi, Kenya to review study progress, provide mentorship opportunities, facilitate team building, and exchange ideas and explore synergies between Projects. Annually, a group of External Technical Advisors will be convened to evaluate performance and provide input on the P01 Program. Team data and documents will be stored in a harmonized web-based platform for easy access between Kenya and US team members. The Project and Core Directors have long-standing collaborations and well-established mechanisms for communications between University of Washington and teams in Kenya. The proposed P01 Program includes Projects in Western Kenya and Nairobi, all of which have participated in numerous collaborative research projects with proposed P01 Program investigators. The P01 Program involves linkages with Kenyatta National Hospital, Kenya Medical Research Institute. the University of Washington-Kenya NGO, and University of Nairobi. In addition, national and County Ministry of Health and MCH clinic facilities will be engaged from study initiation to completion of the Projects. The Administrative Core will be led by Dr. Grace John-Stewart MPI P01 Program who has requisite leadership experience and extensive collaborative research experience in Kenya for >25 years. Dr. John-Stewart will work closely with P01 MPIs Drs. John Kinuthia and Wamalwa (P01 Program Leadership Team) to optimize synergies between Projects, distribute resources equitably between Projects, and facilitate communications. The Administrative Core will oversee research coordination for all three Projects, ensure standardized approaches for data management and analysis in collaboration with the Measurements and Analysis Core, and will oversee development of materials for dissemination and community engagement for all Projects in the Program.

行政核心将提供科学、行政、指导和后勤支持， 完成拟议的P01计划“药物、微生物组和出生的免疫决定因素， 暴露于艾滋病毒感染的儿童的神经发育结果”。行政核心将监督 中央财政管理、项目协调、监管活动、 计划中的项目和核心，以及指导和传播策略，以吸引社区参与 成员和科学界。3个项目中每个项目的每周进度将在项目内部共享; 会议摘要将使用统一的报告方法与整个计划共享。每周 领导团队（MPI John-Stewart、Kinuthia、Wavelwa）会议将包括对所有项目的审查。一个 包括所有项目和核心主任的执行委员会将每月举行会议， 项目每年，将在肯尼亚内罗毕召开P01项目的全体会议，以审查研究 进步，提供导师机会，促进团队建设，交流想法并探索协同效应 项目之间。每年将召集一组外部技术顾问评估业绩 并为P01计划提供投入。团队数据和文件将存储在统一的基于网络的 肯尼亚和美国团队成员之间轻松访问的平台。 项目主任和核心主任有着长期的合作关系和完善的机制， 华盛顿大学和肯尼亚团队之间的沟通。P01计划包括 肯尼亚西部和内罗毕的项目，所有这些项目都参与了许多合作研究 P01计划研究人员的项目。P01计划涉及与肯雅塔国家的联系 医院，肯尼亚医学研究所。华盛顿大学肯尼亚非政府组织和内罗毕大学。 此外，从研究开始，国家和县卫生部和妇幼保健诊所机构将参与研究 完成项目。 行政核心将由Grace John-Stewart博士领导，他具有必要的领导能力 在肯尼亚拥有超过25年的经验和广泛的合作研究经验。约翰-斯图尔特医生会 与P01 MPI John Kinuthia博士和Wavelwa博士（P01项目领导团队）密切合作，以优化协同效应 在项目之间公平分配资源，促进沟通。的 行政核心将监督所有三个项目的研究协调，确保标准化方法 与测量和分析核心合作进行数据管理和分析，并将监督 为该计划中的所有项目开发用于传播和社区参与的材料。