Administrative Core

行政核心将提供科学、行政、指导和后勤支持，以使 完成P01计划“出生和免疫的药物、微生物群和免疫决定因素” 暴露于艾滋病毒感染的儿童的神经发育结果“。行政核心将监督 集中财务管理、项目协调、监管活动、 计划中的项目和核心，以及指导和传播战略，以吸引社区参与 成员和科学界。每周3个项目的进展将在项目内共享； 会议摘要将使用统一的报告方法与整个方案共享。一份周刊 领导团队(MPIS John-Stewart，Kinuthia，Wamalwa)会议将包括对所有项目的审查。一个 包括所有项目和核心主管的执行委员会将每月开会，审查进展情况 项目。每年，P01计划的所有团队会议都将在肯尼亚内罗毕召开，以审查研究 进步，提供指导机会，促进团队建设，交流想法和探索协同效应 在项目之间。每年，将召集一组外部技术顾问来评估业绩 并提供关于P01计划的输入。团队数据和文件将存储在统一的基于网络的 肯尼亚和美国团队成员之间轻松访问的平台。 项目和核心主管有长期的合作和完善的机制，以 华盛顿大学和肯尼亚团队之间的交流。建议的P01计划包括 肯尼亚西部和内罗毕的项目，所有这些项目都参与了许多合作研究 与建议的P01计划调查员合作的项目。P01计划涉及与肯雅塔国家银行的联系 肯尼亚医学研究所医院。华盛顿大学-肯尼亚非政府组织和内罗毕大学。 此外，国家和县卫生部和妇幼保健诊所设施将从研究启动起投入使用 为项目的完成干杯。 行政核心将由格雷斯·约翰-斯图尔特MPI P01计划领导，他具有必要的领导力 在肯尼亚拥有25年的经验和广泛的合作研究经验。约翰-斯图尔特博士将会工作 与P01 MPIs John Kinuthia博士和Wamalwa博士(P01计划领导团队)密切合作，以优化协同效应 在项目之间，在项目之间公平分配资源，并促进沟通。这个 管理核心将监督所有三个项目的研究协调，确保标准化方法 与测量和分析核心合作进行数据管理和分析，并将监督 为方案中的所有项目编写传播和社区参与的材料。

The Administrative Core will provide scientific, administrative, mentorship, and logistical support to enable completion of the proposed P01 Program “Drug, microbiome, and immune determinants of birth and neurodevelopmental outcomes in children with exposure to HIV infection”. The Administrative Core will oversee centralized fiscal management, project coordination, regulatory activities, communications between the Projects and Cores in the Program, and mentorship, and dissemination strategies to engage community members and scientific community. Weekly progress on each of the 3 Projects will be shared within Projects; meetings summaries will be shared with the overall Program using a uniform reporting approach. A weekly Leadership Team (MPIs John-Stewart, Kinuthia, Wamalwa) meeting will include review of all Projects. An Executive Committee that includes all Project and Core Directors will meet monthly to review progress on Projects. Annually, an All-Team meeting of the P01 Program will be convened in Nairobi, Kenya to review study progress, provide mentorship opportunities, facilitate team building, and exchange ideas and explore synergies between Projects. Annually, a group of External Technical Advisors will be convened to evaluate performance and provide input on the P01 Program. Team data and documents will be stored in a harmonized web-based platform for easy access between Kenya and US team members. The Project and Core Directors have long-standing collaborations and well-established mechanisms for communications between University of Washington and teams in Kenya. The proposed P01 Program includes Projects in Western Kenya and Nairobi, all of which have participated in numerous collaborative research projects with proposed P01 Program investigators. The P01 Program involves linkages with Kenyatta National Hospital, Kenya Medical Research Institute. the University of Washington-Kenya NGO, and University of Nairobi. In addition, national and County Ministry of Health and MCH clinic facilities will be engaged from study initiation to completion of the Projects. The Administrative Core will be led by Dr. Grace John-Stewart MPI P01 Program who has requisite leadership experience and extensive collaborative research experience in Kenya for >25 years. Dr. John-Stewart will work closely with P01 MPIs Drs. John Kinuthia and Wamalwa (P01 Program Leadership Team) to optimize synergies between Projects, distribute resources equitably between Projects, and facilitate communications. The Administrative Core will oversee research coordination for all three Projects, ensure standardized approaches for data management and analysis in collaboration with the Measurements and Analysis Core, and will oversee development of materials for dissemination and community engagement for all Projects in the Program.