Apoptosis in recombination-deficient meiocytes
重组缺陷性母细胞中的细胞凋亡
基本信息
- 批准号:7430495
- 负责人:
- 金额:$ 5.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-06-01 至 2009-05-31
- 项目状态:已结题
- 来源:
- 关键词:ApoptosisApoptoticCell CycleCell DeathCellsChromosome SegregationChromosome StructuresChromosomesDefectDevelopmentElementsEnsureGenerationsGenesGeneticGenetic RecombinationGerm CellsHaploidyInjuryMeiosisMeiotic RecombinationMetabolismMolecularMonitorOogenesisOrganismPathway interactionsPloidiesSignal TransductionSpermatogenesisTestingWorkcytotoxichomologous recombinationresponsesexsexual dimorphism
项目摘要
DESCRIPTION (provided by applicant): Meiotic recombination is required to align homologous chromosomes for segregation during the first meiotic division. Meiocytes monitor key steps in meiosis and defective progression results in activation of meiotic checkpoints that induce programmed cell death. Recent studies have identified elements that control programmed cell death in the germline during the course of normal development as well as in response to cytotoxic injury. But less is known about the genetic control of apoptosis in response to errors in meiotic chromosome metabolism. Preliminary work suggests that meiocytes have both DMA damage-dependent and -independent meiotic checkpoints. Intriguingly, these checkpoints are differentially utilized during spermatogenesis and oogenesis. The work detailed in this proposal seeks to answer these specific aims: 1) to determine which apoptotic signaling cascades are activated as a result of meiotic recombination errors in spermatogenesis and oogenesis; 2) to genetically test whether specific pro-apoptotic pathway genes are required for recombination-defective meiocyte cell death and to determine whether the observed sexual dimorphism in cell cycle responses is a consequence of differential use of these genes.
描述(由申请人提供):需要减数分裂重组来排列同源染色体,以便在第一次减数分裂期间进行分离。减数分裂细胞监测减数分裂的关键步骤,缺陷进展会导致减数分裂检查点激活,从而诱导程序性细胞死亡。最近的研究已经确定了在正常发育过程中以及响应细胞毒性损伤时控制种系中程序性细胞死亡的元素。但对于减数分裂染色体代谢错误对细胞凋亡的遗传控制知之甚少。初步研究表明,减数分裂细胞同时具有 DMA 损伤依赖性和非依赖性减数分裂检查点。有趣的是,这些检查点在精子发生和卵子发生过程中的利用有所不同。本提案中详述的工作旨在回答这些具体目标:1)确定哪些细胞凋亡信号级联因精子发生和卵子发生中减数分裂重组错误而被激活; 2) 从基因角度测试重组缺陷性性母细胞死亡是否需要特定的促凋亡途径基因,并确定观察到的细胞周期反应中的性别二态性是否是这些基因差异使用的结果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Francesca Cole其他文献
Francesca Cole的其他文献
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{{ truncateString('Francesca Cole', 18)}}的其他基金
How age-dependent alterations in meiotic recombination cause chromosome mis-segregation in sperm
减数分裂重组的年龄依赖性改变如何导致精子中染色体错误分离
- 批准号:
10198966 - 财政年份:2019
- 资助金额:
$ 5.2万 - 项目类别:
How age-dependent alterations in meiotic recombination cause chromosome mis-segregation in sperm
减数分裂重组的年龄依赖性改变如何导致精子中染色体错误分离
- 批准号:
10842588 - 财政年份:2019
- 资助金额:
$ 5.2万 - 项目类别:
How age-dependent alterations in meiotic recombination cause chromosome mis-segregation in sperm
减数分裂重组的年龄依赖性改变如何导致精子中染色体错误分离
- 批准号:
10704451 - 财政年份:2019
- 资助金额:
$ 5.2万 - 项目类别:
How age-dependent alterations in meiotic recombination cause chromosome mis-segregation in sperm
减数分裂重组的年龄依赖性改变如何导致精子中染色体错误分离
- 批准号:
10440306 - 财政年份:2019
- 资助金额:
$ 5.2万 - 项目类别:
How age-dependent alterations in meiotic recombination cause chromosome mis-segregation in sperm
减数分裂重组的年龄依赖性改变如何导致精子中染色体错误分离
- 批准号:
9974532 - 财政年份:2019
- 资助金额:
$ 5.2万 - 项目类别:
How age-dependent alterations in meiotic recombination cause chromosome mis-segregation in sperm
减数分裂重组的年龄依赖性改变如何导致精子中染色体错误分离
- 批准号:
10667474 - 财政年份:2019
- 资助金额:
$ 5.2万 - 项目类别:
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