Developing and Improving Institutional Animal Resources

描述(申请人提供)：重要的生物医学研究和科学数据的完整性依赖于出色的动物护理。阿拉巴马大学伯明翰分校(UAB)动物护理和使用计划致力于实现长期目标，即根据公认的标准，以合理的成本提供和维护始终如一的高质量、健康的动物，同时为工作人员提供安全和健康的工作场所。这项申请的具体目标是(1)保持健康的小鼠和大鼠，(2)保护人员的健康，(3)控制公共卫生服务(PHS)资助的UAB调查人员的成本。所需设备(12个单独通风的小鼠笼养系统(IVCS)、16个大鼠的IVCS和10个通风动物转运站)将有助于实现这些长期目标和本提案的具体目标。61名调查员将受益于所要求的设备，其中101个小灵通项目每年提供2450万美元的现成资金，87个待决项目申请总计8310万美元的待定资金。将直接受益于这项提案的研究人员拥有联邦资金，支持不同的研究兴趣，翻译适用于癌症、糖尿病、疫苗开发、免疫疾病、神经退行性疾病以及学习和记忆。其中55名调查人员代表大约20个部门，每天平均普查1032笼老鼠。代表四个部门的18名调查人员每天平均普查2835笼老鼠。所要求的设备将是维持和支持国家和国际公认的跨学科研究计划发展所需的基础设施的一部分。

DESCRIPTION (provided by applicant): Vital biomedical research and integrity of scientific data depend on excellent animal care. The University of Alabama at Birmingham (UAB) Animal Care and Use Program is committed to the long-term goals of providing and maintaining consistently high quality, healthy animals according to accepted standards at reasonable cost while providing a safe and healthy workplace for personnel. The specific aims of this application are to (1) maintain healthy mice and rats, (2) protect personnel health, and (3) contain costs for Public Health Service (PHS) funded investigators at UAB. The equipment requested (12 individually ventilated caging systems (IVCSs) for mice, 16 IVCSs for rats, and 10 ventilated animal transfer stations) will assist in attaining these long term goals and the specific aims of this proposal. Sixty-one investigators with 101 PHS projects providing $24.5 million in annual active funding and 87 pending projects requesting $83.1 million in total pending funding will benefit from the requested equipment. The investigators who will directly benefit from this proposal have federal funding that supports diverse research interests with translational applicability to cancer, diabetes, vaccine development, immune disease, neurodegenerative disorders, and learning and memory. Fifty-five of these investigators, representing approximately 20 departments have a combined average daily census of 1032 cages of rats. Eighteen investigators representing four departments have a combined average daily census of 2835 cages of mice. The requested equipment will be a part of the infrastructure needed to maintain and support the growth of a nationally and internationally recognized interdisciplinary research program.