Developing and Improving Institutional Animal Resources

描述（由申请人提供）：重要的生物医学研究和科学数据的完整性取决于良好的动物护理。亚拉巴马大学伯明翰分校（UAB）动物护理和使用计划致力于提供和保持一贯的高品质，健康的动物，根据公认的标准，以合理的成本，同时提供一个安全和健康的工作场所的人员的长期目标。最近的教师招聘使用大型动物和继续现有的研究计划，导致了严重的大型动物住房危机。本申请的具体目的是（1）维持健康的大型动物（狗、非人灵长类动物、猪），为大型动物提供适当的住房，并为狗提供户外运动区;（2）丰富人员的心理健康，使他们有机会与狗一起在户外锻炼，（3）通过翻新/翻新来控制调查人员的费用。重新启用5000 nsf的大型动物饲养和支持空间（Cook Springs Large Animal Facility，CSLAF）。这个额外的空间将允许长期住房的狗繁殖殖民地（30-40只狗），这是一个宝贵的国家资源，犬血液疾病和干细胞资源（CBD和SCR）。CBD&SCR为研究血友病、贫血和周期性血细胞生成机制和治疗的研究人员（UAB和其他机构）提供资源。这个殖民地在翻新后的空间的住宿将允许现有的UAB大型动物研究人员保持研究时间表。21名UAB调查员和其他机构的10名调查员将从拟议的翻修中受益，这些机构有61个PHS项目（每年2 230万美元，正在进行）和19个未决项目（2 220万美元）。

DESCRIPTION (provided by applicant): Vital biomedical research and integrity of scientific data depend on excellent animal care. The University of Alabama at Birmingham (UAB) Animal Care and Use Program is committed to the long-term goals of providing and maintaining consistently high quality, healthy animals according to accepted standards at reasonable cost while providing a safe and healthy workplace for personnel. Recent faculty recruits using large animals and continued existing research programs has resulted in a severe large animal housing crisis. The specific aims of this application are to (1) maintain healthy large animals (dogs, nonhuman primates, pigs), by providing appropriate housing for large animals, with access to outdoor exercise areas for dogs; (2) Enrich personnel mental health allowing opportunity for dogs with which they have bonded to exercise outdoors and (3) contain costs for investigators by the renovation/reactivation of 5000 nsf of large animal housing and support space (Cook Springs Large Animal Facility, CSLAF). This additional space will allow long term housing of a dog breeding colony (30-40 dogs) that is a valuable national resource, Canine Blood Disorders and Stem Cell Resource (CBD&SCR). The CBD&SCR provides resources to investigators (UAB and other institutions) studying mechanisms and treatments of hemophilia, anemia, and cyclic hematopoiesis. The accommodation of this colony in the renovated space will allow existing UAB large animal researchers to maintain research schedules. Twenty-one UAB investigators and 10 investigators at other institutions with 61 PHS projects ($22.3 M annual, active) and 19 pending projects ($22.2M) will benefit from the proposed renovation.