International Mouse Strain Resource (IMSR)

描述（由申请人提供）： 国际小鼠品系资源（IMSR）的目标是促进获得用于基础和转化研究的小鼠资源和人类疾病小鼠模型。IMSR的独特和关键作用是统一有关全球小鼠资源的信息，包括近交系，突变体和遗传工程小鼠作为育种种群，冷冻保存的胚胎和配子，以及ES（胚胎干）细胞系。在IMSR网站（www.imsr.org）上，用户可以搜索小鼠资源，找到用于研究的品系，了解品系的详细信息，联系订购小鼠的储存库，并链接到表型和疾病模型描述。 在这里，我们建议进一步开发IMSR基础设施和用户界面：（1）更好地表示基因捕获和靶向ES细胞系，这些细胞系将成为开发大规模基因敲除项目的主要资源类型;（2）扩展IMSR表示，以便使用其他新的和开发中的技术创建的资源可以容易地并入IMSR;（3）改进IMSR的自动化和报告功能;（4）增强网络内容，使用户能够访问其他数据;（5）改进不太熟悉小鼠模型的翻译和临床研究人员的网络可用性。我们还将支持关键的IMSR策展活动，以确保IMSR中的数据继续改进并符合科学界的标准。这包括开发管理工具，以提高IMSR利用其他在线资源数据的能力。在这个时候，当许多新的独特的鼠标资源正在迅速扩大和新的存储库正在建立，IMSR的增长和变化与科学界的进步，并加强其基础设施定位，以充分支持这些新的资源需求是至关重要的。与公共卫生的相关性：几乎所有人类医学的进展都依赖于动物模型的使用，而这些模型系统中最主要的是实验室小鼠。国际小鼠品系资源（IMSR）是一个可公开访问的在线资源，帮助科学界查找有关全球小鼠资源的信息，定位可以获得它们的资源库，并订购所需的资源。通过IMSR，用户还可以链接到表型和疾病模型描述，以评估和选择最合适的实验模型进行研究。拟议的IMSR增强将改善对数千种新的宝贵鼠标资源的访问，方法是在开发时将其纳入，增加具有独特鼠标资源的储存库网站，并增加在线提供给用户的信息内容。

DESCRIPTION (provided by applicant): The goal of the International Mouse Strain Resource (IMSR) is to facilitate access to mouse resources and mouse models of human disease that are used for basic and translational research. The unique and pivotal role of IMSR is in unifying information about mouse resource holdings worldwide, including inbred, mutant, and genetically engineered mice maintained as breeding stock, cryopreserved embryos and gametes, and ES (embryonic stem) cell lines. At the IMSR website (www.imsr.org), users can search for mouse resources, locate strains for their research, learn details about a strain, contact a repository for ordering mice, and link to phenotype and disease model descriptions. Here, we propose to further develop the IMSR infrastructure and user interface: (1) to better represent gene trapped and targeted ES cell lines that will become a major resource type in the developing large-scale gene knockout projects; (2) to expand IMSR representation such that resources created using other new and developing technologies can be easily incorporated into IMSR; (3) to improve automation and reporting functions of the IMSR; (4) to enhance web content to provide user access to additional data; and (5) to improve web usability for translational and clinical researchers less familiar with mouse models. We will also support the critical IMSR curation activities to ensure that the data in IMSR continue to improve and are consistent with scientific community standards. This includes development of curation tools to enhance the ability of IMSR to utilize data from other online resources. It is imperative at this time, when many new unique mouse resources are rapidly expanding and new repositories are being established, that IMSR grow and change with the scientific community's progress and enhance its infrastructure to be positioned to fully support these new resource needs. Relevance to Public Health: Virtually all advances in human medicine rely on the use of animal models, and chief among these model systems is the laboratory mouse. The International Mouse Strain Resource (IMSR) is a publicly accessible online resource that assists the scientific community in finding information about worldwide mouse resources, locating the repositories from which they can be obtained, and ordering needed resources. Through IMSR users also can link to phenotype and disease model descriptions to evaluate and select the most appropriate experimental model for their research. The proposed enhancements to IMSR will improve access to thousands of new valuable mouse resources by enabling their inclusion as they are developed, by adding repository sites with unique mouse resource holdings, and by enhancing information content available to the user online.