Electronic Access to Mouse Tumor Data

小鼠肿瘤数据的电子获取

• 批准号: 7537195
• 负责人: Janan T. EPPIG
• 金额: $ 74.96万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-10 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7537195
• 关键词: Affect; Alleles; Animal Model; Atlas of Cancer Mortality in the United States; Base Sequence; Biological; Biological Models; Biology; Cancer Biology; Clinical; Collection; Communities; Community Outreach; Computer software; Data; Databases; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Disease; Disease model; Electronics; Engineering; Experimental Models; Fluorescent in Situ Hybridization; Frequencies; Gene Expression; Gene Targeting; Gene Transfer Techniques; Genetic; Genetic Research; Genetically Engineered Mouse; Genome; Genomic Instability; Genomics; Goals; Grant; Histopathology; Human; Human Biology; Hybridization Array; Hyperplasia; Hypertrophy; Image; Imagery; Inbred Strains Mice; Incidence; Informatics; Internet; Israel; Loss of Heterozygosity; Maintenance; Malignant Neoplasms; Maps; Measures; Metadata; Modeling; Molecular; Mouse Strains; Mus; Mutation; Neoplasm Metastasis; Neoplasms; Oncogenes; Pathologist; Pathology; Pattern; Point Mutation; Predisposition; Process; Public Health; Quantitative Trait Loci; Reporting; Research; Research Infrastructure; Research Personnel; Resistance; Resources; Services; Somatic Mutation; Spectral Karyotyping; Swelling; System; Techniques; Technology; Tissues; Tumor Biology; Ursidae Family; cancer genetics; cancer initiation; comparative genomic hybridization; data acquisition; data mining; genetic profiling; genetic variant; genome-wide; human cancer mouse model; improved; insight; mouse model; mutant; neoplastic; novel; prototype; response; software development; symposium; tool; tumor; tumorigenesis; usability

Our overall goal is to develop an informatics infrastructure essential for supporting basic cancer genetics research using the mouse as a model system for human cancer. The Mouse Tumor Biology (MTB) Database (http://tumor.informatics.iax.org) has become a primary resource for researchers seeking integrated information on the frequency, incidence, genetics, and pathology of neoplastic disorders in mice. MTB emphasizes data on tumors that develop characteristically in different genetically defined strains of mice (inbred, mutant, and genetically engineered) that serve as disease models for human cancers. MTB provides data to assist in selection of strains for experimentation and is a platform for mining data on tumor development and patterns of metastases. We now propose to build on this resource. Specifically: ¿ We will improve MTB's coverage of data on genetic changes in tumors, by including a growing body of information on whole genome profiling of genetic and gene expression changes in tumors. ¿ We will develop tools for exploring chromosomal and sequence-based maps of cancer-associated susceptibility and modifier loci and somatic mutations that occur in tumors. ¿ We will continue to populate MTB with data on strain-specific patterns of tumorigenesis in inbred, mutant, and genetically engineered mice, including data on tumor diagnoses and histopathology images. ¿ We will support the infrastructure of MTB through database maintenance, development of new software components, user support services, and community outreach activities. Our objective is to provide the user with current data about mouse models for human cancer and provide tools for exploring and exploiting MTB data to inspire new hypotheses that may provide novel insights into the process of cancer initiation and progression. Relevance to Public Health: The Mouse Tumor Biology Database (MTB) is a publicly accessible internet resource that the scientific community uses to assist in selection of mouse strains that will serve as experimental models for human cancer. Researchers interrogate MTB for information on tumor incidence, data on genetic variants carried by strains, and on somatic changes that occur characteristically in specific cancers. Priority for data curation and representation in the database is given to those strains that serve as models for the predominant human cancers and those new strains developed specifically to reflect the human clinical disease. The expansion and visualization tools planned for MTB will further enhance the value of the mouse as a model system for understanding human biology and cancer processes.

我们的总体目标是开发支持基本癌症遗传学所必需的信息学基础设施 使用小鼠作为人类癌症模型系统的研究。小鼠肿瘤生物学 (MTB) 数据库 (http://tumor.informatics.iax.org) 已成为研究人员寻求帮助的主要资源 关于小鼠肿瘤疾病的频率、发病率、遗传学和病理学的综合信息。 MTB 强调在不同基因定义菌株中特征性发展的肿瘤数据 作为人类癌症疾病模型的小鼠（近交系、突变型和基因工程小鼠）。山地车 提供数据协助选择实验菌株，是挖掘肿瘤数据的平台 转移的发展和模式。 我们现在建议以这一资源为基础。具体来说： ¿ 我们将通过纳入越来越多的肿瘤遗传变化数据来提高 MTB 的覆盖范围。 有关肿瘤遗传和基因表达变化的全基因组分析的信息。 ¿ 我们将开发工具来探索癌症相关的染色体和基于序列的图谱 肿瘤中发生的易感性和修饰基因座以及体细胞突变。 ¿ 我们将继续向 MTB 提供有关近交系肿瘤发生的菌株特异性模式的数据， 突变体和基因工程小鼠，包括肿瘤诊断和组织病理学图像的数据。 ¿ 我们将通过数据库维护、开发新产品来支持 MTB 基础设施 软件组件、用户支持服务和社区外展活动。 我们的目标是为用户提供有关人类癌症小鼠模型的最新数据，并提供 用于探索和利用 MTB 数据来激发新假设的工具，这些假设可能会提供新颖的见解 癌症发生和进展的过程。 与公共卫生的相关性：小鼠肿瘤生物学数据库 (MTB) 是一个可公开访问的互联网 科学界用来协助选择小鼠品系的资源，这些小鼠品系将作为 人类癌症的实验模型。研究人员向 MTB 询问有关肿瘤发生率的信息， 有关菌株携带的遗传变异的数据，以及特定情况下典型发生的体细胞变化的数据 癌症。数据库中的数据管理和表示优先考虑那些充当 主要人类癌症的模型以及专门开发来反映 人类临床疾病。计划用于 MTB 的扩展和可视化工具将进一步增强 小鼠作为理解人类生物学和癌症过程的模型系统的价值。