Enhancing the JaxMice Database Resource

增强 JaxMice 数据库资源

基本信息

  • 批准号:
    7435374
  • 负责人:
  • 金额:
    $ 13.19万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-06-01 至 2010-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): ENHANCING THE JAXMICE DATABASE RESOURCE Many factors have converged to lead to a rapid increase in the use of mouse models in biomedical research, and in the rate that new mouse strains are being generated. These include: the completion of the mouse genome sequence; tools to genetically modify the mouse genome; large-scale mutagenesis projects; the similarity of mouse and human genomes and physiology; and the utility of the mouse as a model of human disease. In the next five years, thousands of ES cells and mouse lines will be made by the North American and European Gene Trap Consortia and the NIH Knockout Mouse Project (KOMP). The Jackson Laboratory (TJL), as the most prominent Repository of mouse models, currently distributes over 2,900 strains to the scientific community and is gearing up to be able to accommodate the anticipated increase in the number of mouse lines that will need to be maintained. Critical to this process is the means to develop and maintain the information that biomedical researchers need to select and use the appropriate model. Currently, this information is stored in the JaxMice database in free text phenotype descriptions. This project proposes to assign phenotype terms from the Mammalian Phenotype Ontology developed by the Mouse Genome Informatics (MGI) project at TJL and disease terms from the National Center for Biotechnology Information's (NCBI) Online Mendelian Inheritance in Man database to mice in TJL's Repository. Therefore, the JaxMice web site will display essential information from both MGI and NCBI to create tailored views of information on Repository mice. This project will have two crucial benefits: users will be able to search more effectively to find strains important for their research, and the curation process will be much more efficient, enabling the curation staff to provide current information for more mouse models. This will allow curation at the scale that will be required to keep up with the increasing pace of production of mouse models of human disease. Relevance to Public Health: A mouse in any repository is of no value unless the members of the scientific community can identify it as being relevant to their work; this project will expedite this process by assigning phenotype and disease terms from controlled vocabularies to the mice in TJL's Repository. This effort will enable TJL to better serve the research community in the selection and use of mouse models for biomedical research.
描述(由申请人提供): 增强JAXMICE数据库资源 许多因素共同导致小鼠模型在生物医学中的使用迅速增加。 研究,以及新的小鼠品系的产生速度。其中包括:完成小鼠基因组测序;对小鼠基因组进行遗传修饰的工具;大规模诱变 项目;小鼠和人类基因组和生理学的相似性;以及小鼠作为 人类疾病的模型。在接下来的五年里,北美和欧洲的基因捕获联盟以及NIH敲除小鼠项目(KOMP)将制造数千个ES细胞和小鼠品系。 杰克逊实验室(TJL)作为最著名的小鼠模型库,目前向科学界分发了2,900多个品系,并正在准备能够适应预期增加的小鼠品系数量。这一过程的关键是开发和维护生物医学研究人员选择和使用适当模型所需信息的方法。目前,这些信息以自由文本表型描述的形式存储在JaxMice数据库中。 该项目建议从TJL的小鼠基因组信息学(MGI)项目开发的哺乳动物表型本体论中分配表型术语,并从国家遗传学中心分配疾病术语。 生物技术信息(NCBI)在线孟德尔遗传在人类数据库中的小鼠在TJL的 仓库。因此,JaxMice网站将显示来自MGI和NCBI的基本信息,以创建关于Repository mice的定制信息视图。该项目将有两个关键的好处:用户将能够更有效地搜索,以找到对他们的研究重要的菌株,并且策展过程将更加有效,使策展人员能够为更多的小鼠模型提供最新信息。这将允许在所需的规模上进行管理,以跟上人类疾病小鼠模型生产的日益增长的步伐。 与公共卫生的相关性:任何存储库中的鼠标都没有任何价值,除非 科学界可以确定它与他们的工作相关;该项目将通过将受控词汇表中的表型和疾病术语分配给TJL知识库中的小鼠来加速这一过程。这一努力将使TJL能够更好地服务于研究界,选择和使用小鼠模型进行生物医学研究。

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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Michael Sasner其他文献

Michael Sasner的其他文献

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{{ truncateString('Michael Sasner', 18)}}的其他基金

Enhancing the JaxMice Database Resource
增强 JaxMice 数据库资源
  • 批准号:
    7864608
  • 财政年份:
    2009
  • 资助金额:
    $ 13.19万
  • 项目类别:
Enhancing the JaxMice Database Resource
增强 JaxMice 数据库资源
  • 批准号:
    7631411
  • 财政年份:
    2007
  • 资助金额:
    $ 13.19万
  • 项目类别:
Enhancing the JaxMice Database Resource
增强 JaxMice 数据库资源
  • 批准号:
    7264901
  • 财政年份:
    2007
  • 资助金额:
    $ 13.19万
  • 项目类别:

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