Enhancing the JaxMice Database Resource

描述(由申请人提供)： 增强JAXMICE数据库资源 许多因素汇聚在一起，导致在生物医学中使用小鼠模型的数量迅速增加 研究，以及产生新的老鼠品系的速度。这些包括：完成小鼠基因组序列；对小鼠基因组进行基因修改的工具；大规模突变 项目；老鼠和人类基因组和生理学的相似性；以及老鼠作为一种 人类疾病的模型。在接下来的五年里，北美和欧洲的基因陷阱联盟和NIH基因敲除小鼠项目(KOMP)将制造数千个ES细胞和小鼠品系。 杰克逊实验室(TJL)作为最著名的小鼠模型资料库，目前向科学界分发了2900多个品系，并正在做好准备，以适应预计将需要维持的小鼠品系数量的增加。这一过程的关键是开发和维护生物医学研究人员选择和使用适当模型所需的信息的手段。目前，这些信息以自由文本表型描述的形式存储在JaxMice数据库中。 这个项目建议分配由TJL的小鼠基因组信息学(MGI)项目开发的哺乳动物表型本体论的表型术语和来自国家疾病研究中心的疾病术语 生物技术信息(NCBI)在线孟德尔遗传在人数据库中对TJL‘s小鼠的遗传 存储库。因此，JaxMice网站将显示来自MGI和NCBI的基本信息，以创建关于存储库老鼠的信息的定制视图。这个项目将有两个关键的好处：用户将能够更有效地搜索，以找到对他们的研究重要的品系，管理过程将更加高效，使管理人员能够为更多的老鼠模型提供最新信息。这将允许以所需的规模进行管理，以跟上生产人类疾病小鼠模型的日益增长的速度。 与公共卫生相关：任何存储库中的鼠标都没有价值，除非 科学界可以确定它与他们的工作相关；该项目将通过将受控词汇中的表型和疾病术语分配给TJL储存库中的小鼠来加快这一过程。这一努力将使TJL能够在生物医学研究中选择和使用小鼠模型方面更好地服务于研究界。

DESCRIPTION (provided by applicant): ENHANCING THE JAXMICE DATABASE RESOURCE Many factors have converged to lead to a rapid increase in the use of mouse models in biomedical research, and in the rate that new mouse strains are being generated. These include: the completion of the mouse genome sequence; tools to genetically modify the mouse genome; large-scale mutagenesis projects; the similarity of mouse and human genomes and physiology; and the utility of the mouse as a model of human disease. In the next five years, thousands of ES cells and mouse lines will be made by the North American and European Gene Trap Consortia and the NIH Knockout Mouse Project (KOMP). The Jackson Laboratory (TJL), as the most prominent Repository of mouse models, currently distributes over 2,900 strains to the scientific community and is gearing up to be able to accommodate the anticipated increase in the number of mouse lines that will need to be maintained. Critical to this process is the means to develop and maintain the information that biomedical researchers need to select and use the appropriate model. Currently, this information is stored in the JaxMice database in free text phenotype descriptions. This project proposes to assign phenotype terms from the Mammalian Phenotype Ontology developed by the Mouse Genome Informatics (MGI) project at TJL and disease terms from the National Center for Biotechnology Information's (NCBI) Online Mendelian Inheritance in Man database to mice in TJL's Repository. Therefore, the JaxMice web site will display essential information from both MGI and NCBI to create tailored views of information on Repository mice. This project will have two crucial benefits: users will be able to search more effectively to find strains important for their research, and the curation process will be much more efficient, enabling the curation staff to provide current information for more mouse models. This will allow curation at the scale that will be required to keep up with the increasing pace of production of mouse models of human disease. Relevance to Public Health: A mouse in any repository is of no value unless the members of the scientific community can identify it as being relevant to their work; this project will expedite this process by assigning phenotype and disease terms from controlled vocabularies to the mice in TJL's Repository. This effort will enable TJL to better serve the research community in the selection and use of mouse models for biomedical research.