Enhancing the JaxMice Database Resource

描述（由申请人提供）： 增强 JAXMICE 数据库资源 许多因素共同导致小鼠模型在生物医学领域的使用迅速增加 研究以及新小鼠品系的产生速度。其中包括：小鼠基因组序列的完成；基因改造小鼠基因组的工具；大规模诱变 项目；小鼠和人类基因组和生理学的相似性；以及鼠标作为 人类疾病模型。未来五年内，北美和欧洲基因陷阱联盟以及 NIH 基因敲除小鼠项目 (KOMP) 将生产数千个 ES 细胞和小鼠品系。 杰克逊实验室 (TJL) 作为最著名的小鼠模型储存库，目前向科学界分发了 2,900 多个品系，并正在做好准备，以适应需要维护的小鼠品系数量的预期增长。此过程的关键是开发和维护生物医学研究人员选择和使用适当模型所需的信息的方法。目前，该信息以自由文本表型描述的形式存储在 JaxMice 数据库中。 该项目建议分配来自 TJL 小鼠基因组信息学 (MGI) 项目开发的哺乳动物表型本体的表型术语和来自国家癌症中心的疾病术语。 生物技术信息 (NCBI) 在线人类孟德尔遗传数据库中 TJL 小鼠的信息 存储库。因此，JaxMice 网站将显示来自 MGI 和 NCBI 的重要信息，以创建有关 Repository 小鼠的定制信息视图。该项目将有两个重要的好处：用户将能够更有效地搜索以找到对其研究重要的菌株，并且管理过程将更加高效，使管理人员能够为更多小鼠模型提供当前信息。这将使得管理规模能够跟上人类疾病小鼠模型生产的不断增长的步伐。 与公共健康的相关性：任何存储库中的鼠标都没有任何价值，除非该存储库的成员 科学界可以认为它与他们的工作相关；该项目将通过将受控词汇中的表型和疾病术语分配给 TJL 存储库中的小鼠来加快这一过程。这项努力将使 TJL 能够更好地为研究界服务，选择和使用小鼠模型进行生物医学研究。

DESCRIPTION (provided by applicant): ENHANCING THE JAXMICE DATABASE RESOURCE Many factors have converged to lead to a rapid increase in the use of mouse models in biomedical research, and in the rate that new mouse strains are being generated. These include: the completion of the mouse genome sequence; tools to genetically modify the mouse genome; large-scale mutagenesis projects; the similarity of mouse and human genomes and physiology; and the utility of the mouse as a model of human disease. In the next five years, thousands of ES cells and mouse lines will be made by the North American and European Gene Trap Consortia and the NIH Knockout Mouse Project (KOMP). The Jackson Laboratory (TJL), as the most prominent Repository of mouse models, currently distributes over 2,900 strains to the scientific community and is gearing up to be able to accommodate the anticipated increase in the number of mouse lines that will need to be maintained. Critical to this process is the means to develop and maintain the information that biomedical researchers need to select and use the appropriate model. Currently, this information is stored in the JaxMice database in free text phenotype descriptions. This project proposes to assign phenotype terms from the Mammalian Phenotype Ontology developed by the Mouse Genome Informatics (MGI) project at TJL and disease terms from the National Center for Biotechnology Information's (NCBI) Online Mendelian Inheritance in Man database to mice in TJL's Repository. Therefore, the JaxMice web site will display essential information from both MGI and NCBI to create tailored views of information on Repository mice. This project will have two crucial benefits: users will be able to search more effectively to find strains important for their research, and the curation process will be much more efficient, enabling the curation staff to provide current information for more mouse models. This will allow curation at the scale that will be required to keep up with the increasing pace of production of mouse models of human disease. Relevance to Public Health: A mouse in any repository is of no value unless the members of the scientific community can identify it as being relevant to their work; this project will expedite this process by assigning phenotype and disease terms from controlled vocabularies to the mice in TJL's Repository. This effort will enable TJL to better serve the research community in the selection and use of mouse models for biomedical research.