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Examining the role of the neighborhood environment on muscle function in older adults

检查社区环境对老年人肌肉功能的作用

基本信息

批准号：
10784116
负责人：
Catherine Duchowny
金额：
$ 24.9万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-01-01 至 2025-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10784116
关键词：
Affect Aging Award Behavioral Bioenergetics Biogenesis Biological California Cessation of life Characteristics Clinical Cohort Studies Complement Complex Data Data Set Dedications Disease Elderly Environment Epidemiologic Methods Future Goals Health Health and Retirement Study Individual Intervention Link Measurement Measures Mediating Mediation Mentorship Mitochondria Muscle Muscle Mitochondria Muscle Weakness Muscle function Musculoskeletal Neighborhoods Outcome Pathway interactions Phase Physical activity Physiology Positioning Attribute Public Health Research Risk Factors Role San Francisco Skeletal Muscle Skin Social Environment Social Sciences Testing Training Universities Work biological research built environment career clinical epidemiology design disability experience health data insight multidisciplinary multiple chronic conditions muscle physiology muscle strength prevent reduced muscle strength skills social social culture social epidemiology social health determinants walkability

项目摘要

PROJECT SUMMARY/ABSTRACT Poor muscle function is a pressing public health problem: half of all U.S. older adults meet criteria for muscle weakness. Poor muscle function, defined by low muscle strength and power, is a major risk factor for a host of negative health outcomes, including functional limitations, disability and multimorbidity. Neighborhood characteristics predict functional limitations, disability and death, but the biologic mechanisms are poorly understood. Muscle function and its underlying physiology, including mitochondrial bioenergetics, are a biologically promising, but unexplored mechanism linking neighborhoods and disability. While previous research has examined neighborhood effects on disability, almost no prior work has explored neighborhood effects on muscle function and no research has evaluated connections with skeletal muscle mitochondria. Neighborhood factors represent an untapped opportunity in musculoskeletal health research directly aligned with NIA's strategic goals to “assess the interplay among environmental, sociocultural, behavioral, and biological determinants to understand and prevent disease” while “exploring the relationship among mitochondrial biogenesis and musculoskeletal function”. Understanding how neighborhood characteristics get `under the skin' and contribute to poor muscle function, reduced physical activity, and alter mitochondrial bioenergetics will enhance our understanding of what social and biologic risk factors matter most for muscle function and could be targets for interventions. This study proposal leverages data from two well-characterized datasets, the Health and Retirement Study (HRS) and the Study of Muscle Mobility and Aging (SOMMA) to identify which features of the neighborhood environment are related to muscle function, physical activity and mitochondrial health in older adults. This proposal seeks to: (1) assess which predictors of the neighborhood environment affect muscle function in older adults; (2) examine the relationship between the neighborhood environment and skeletal muscle mitochondrial bioenergetics, and; (3) test the hypothesis that mitochondrial bioenergetics and physical activity mediate the link between the neighborhood environment and muscle function. Complementing this research, a detailed training plan, carried out at the University of California, San Francisco, will build on the applicant's prior training in social and clinical epidemiology to include (1) neighborhood research on planning/design; (2) the assessment of skeletal muscle mitochondrial bioenergetics, and; (3) causal mediation analysis. This integrated sociobiologic training will prepare the applicant for a successful independent research career focused on incorporating the social determinants of health into the study of musculoskeletal research. Findings from this proposal will provide critical insights into understanding the complex, multifactorial social and biologic contributors of poor muscle function in older adults.

项目总结/文摘