Studies on Antimicrobial resistance in bacteria of veterinary importance

具有兽医重要性的细菌的耐药性研究

• 批准号: 10775687
• 负责人: James Trybus
• 金额: $ 3万
• 依托单位: NC STATE DEPT OF AGRI AND CONSUMER SERV
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10775687
• 关键词: Studies; Antimicrobial; resistance; bacteria; veterinary

Project Summary The North Carolina Veterinary Diagnostic Laboratory System is a full-service multidisciplinary veterinary diagnostic laboratory. The NCVDLS received over 44,000 client accessions in 2018. Our diagnostic laboratory is uniquely situated to screen for and research existing and emerging microbial pathogens of agricultural and companion animal importance given the prominence of animal agriculture (poultry and swine production) in our state and continual urban/suburban growth. The Bacteriology section services our main laboratory and our three branch laboratories. Along with bacteriology submissions from clients they process high volumes of in-house samples from necropsy. The bacteriology laboratory has MALDI-TOF and available BSL3 workspace. The Bacteriology laboratory has performed over 13,900 tests in the year 2018 on clinical samples, tissue, serum, bacterial isolates, and environmental samples. The NCVDLS hopes to partner with the FDA and play an active role in pet food and animal feed contamination investigations: 1) Participation in VPO designated sample analyses and surveillance activities to promote animal health and welfare and add to the Vet-LIRN Network's surge capacity to assist in emergency and large-scale outbreak testing. 2) Provide analytical data to support regulatory actions by developing and using standardized methods, equipment platforms, and reporting methods, continued participation in proficiency testing provided by the VPO, continue investigating consumer reported cases as requested by the VPO, and continuing to improve and implement standardized quality management systems as designated by the VPO. 3) Participate in small-scale antibiotic susceptibility testing studies by sharing bacterial isolates to address emerging antimicrobial resistance issues, and participate in AMR surveillance. The bacteriology section of the NCVDLS hopes to engage in cooperative activities with the FDA Vet-LIRN, the Vet-LIRN network, and federal, state, local and tribal organizations to promote animal health and feed and food safety and security.

项目摘要 北卡罗来纳州兽医诊断实验室系统是一个全方位服务的多学科兽医 诊断实验室NCVDLS在2018年收到了超过44，000个客户加入。我们的诊断 实验室是独特的位置，以筛选和研究现有的和新出现的微生物病原体， 鉴于畜牧业（家禽和猪）的突出地位，农业和伴侣动物的重要性 在我们的国家和持续的城市/郊区的增长。细菌学部分服务于我们的主要 实验室和三个分支实验室。沿着客户提交的细菌学报告， 大量的内部尸检样本。细菌学实验室拥有MALDI-TOF并可用 BSL 3工作区。细菌学实验室在2018年对临床进行了超过13，900次测试。 样品、组织、血清、细菌分离物和环境样品。NCVDLS希望与 FDA在宠物食品和动物饲料污染调查中发挥积极作用： 1)参与VPO指定的样品分析和监测活动，以促进动物健康 和福利，并增加Vet-LIRN网络的激增能力，以协助紧急和大规模的 爆发测试 2)通过制定和使用标准化方法，提供分析数据，以支持监管行动， 设备平台和报告方法，继续参与能力验证提供的 VPO，继续按照VPO的要求调查消费者报告的案件，并继续 按照VPO的要求，改进和实施标准化的质量管理体系。 3)通过共享细菌分离株参与小规模抗生素敏感性测试研究，以解决 新出现的抗生素耐药性问题，并参与AMR监测。 NCVDLS的细菌学部门希望与FDA Vet-LIRN， Vet-LIRN网络，以及联邦、州、地方和部落组织，以促进动物健康、饲料和食品 安全和安保。