Studies on Antimicrobial resistance in bacteria of veterinary importance

项目摘要 北卡罗来纳州兽医诊断实验室系统是一家全方位服务的多学科兽医 诊断实验室。2018年，NCVDLS收到了超过4.4万份客户申请。我们的诊断 实验室位于独特的位置，用于筛选和研究现有的和正在出现的微生物病原体。 鉴于畜牧业的突出地位(家禽和猪)，农业和伴生动物的重要性 生产)和城市/郊区的持续发展。细菌科为我们的主要 实验室和我们的三个分支实验室。以及他们处理的客户的细菌学意见书 大量的内部尸检样本。细菌学实验室有MALDI-TOF和 BSL3工作空间。细菌学实验室在2018年进行了超过13,900次临床测试 样本、组织、血清、细菌分离物和环境样本。NCVDLS希望与 FDA并在宠物食品和动物饲料污染调查中发挥积极作用： 1)参加VPO指定的样本分析和监测活动，以促进动物健康 和福利，并增加了兽医-LIRN网络的激增能力，以协助紧急和大规模 疫情检测。 2)通过开发和使用标准化方法，提供支持监管行动的分析数据； 设备平台和报告方法，继续参加由 VPO，应VPO的要求继续调查消费者报告的案件，并继续 改进和实施VPO指定的标准化质量管理体系。 3)通过共享细菌分离物来参与小规模的抗生素敏感性测试研究 新出现的抗菌素耐药性问题，并参与AMR监测。 NCVDLS细菌科希望与FDA Vet-LIRN， VET-LIRN网络，以及联邦、州、地方和部落组织，以促进动物健康以及饲料和食品 安全和安保。

Project Summary The North Carolina Veterinary Diagnostic Laboratory System is a full-service multidisciplinary veterinary diagnostic laboratory. The NCVDLS received over 44,000 client accessions in 2018. Our diagnostic laboratory is uniquely situated to screen for and research existing and emerging microbial pathogens of agricultural and companion animal importance given the prominence of animal agriculture (poultry and swine production) in our state and continual urban/suburban growth. The Bacteriology section services our main laboratory and our three branch laboratories. Along with bacteriology submissions from clients they process high volumes of in-house samples from necropsy. The bacteriology laboratory has MALDI-TOF and available BSL3 workspace. The Bacteriology laboratory has performed over 13,900 tests in the year 2018 on clinical samples, tissue, serum, bacterial isolates, and environmental samples. The NCVDLS hopes to partner with the FDA and play an active role in pet food and animal feed contamination investigations: 1) Participation in VPO designated sample analyses and surveillance activities to promote animal health and welfare and add to the Vet-LIRN Network's surge capacity to assist in emergency and large-scale outbreak testing. 2) Provide analytical data to support regulatory actions by developing and using standardized methods, equipment platforms, and reporting methods, continued participation in proficiency testing provided by the VPO, continue investigating consumer reported cases as requested by the VPO, and continuing to improve and implement standardized quality management systems as designated by the VPO. 3) Participate in small-scale antibiotic susceptibility testing studies by sharing bacterial isolates to address emerging antimicrobial resistance issues, and participate in AMR surveillance. The bacteriology section of the NCVDLS hopes to engage in cooperative activities with the FDA Vet-LIRN, the Vet-LIRN network, and federal, state, local and tribal organizations to promote animal health and feed and food safety and security.