Culture–specific neurodevelopmental assessment of HIV-affected children

对受艾滋病毒影响的儿童进行文化特定的神经发育评估

基本信息

  • 批准号:
    10785272
  • 负责人:
  • 金额:
    $ 37.58万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-03-15 至 2025-02-28
  • 项目状态:
    未结题

项目摘要

With NIH funding we have developed BPG (Brain Powered Games), a CCRT (Computerized Cognitive Rehabilitation Therapy) digital games package for HIV+ school children in the sub-Sahara. As a child plays, BPG will gather game data for neurocognitive assessment. BPG has been pilot-tested in HIV+ children. In Study Aim 1 we will evaluate concurrent and predictive validity. Here we will evaluate whether BPG static (baseline) assessment will correspond well to our gold standard static measures (KABC-II, TOVA, CogState). Compared to these, we hypothesize that dynamic BPG assessments will provide for a more sensitive evaluation of brain/behavior function as affected by more proximal factors of HIV exposure, disease and treatment. We also hypothesize that dynamic assessments will be more sensitive to distal developmental risk factors (e.g., SES, nutrition/growth, maternal caregiving quality). In Study Aim 2 we will compare the validity of BPG static and dynamic assessments. Here we will validate BPG static and dynamic assessments with a gold standard of neuropsychological tests previously used with children 5 -12 years old at our two study sites (Kampala, Uganda and Blantyre, Malawi). Children will be in 3 cohorts: 1) HIV-positive; 2) HIV exposed and uninfected (HEU); 3) HIV unexposed and uninfected (HUU). Cohorts will be well characterized due to participating in our previous NIH-sponsored HIV clinical trials. We hypothesize that BGP-based static and dynamic assessments will be sensitive to cohorts’ prior longitudinal trajectories as affected by proximal and distal risk factors that cause developmental delay and cognitive problems, as measured in our previous clinical trial studies with these cohorts. In Study Aim 3 we will test the sensitivity of dynamic assessment to learning loss after training ends. An advantage of dynamic assessment should be its sensitivity to learning loss over time as a measure of strength of positive neuroplasticity in brain/behavior functions. Here we will test sensitivity by evaluating all 3 cohorts with BPG and gold standard tests (KABC-II, TOVA, CogState) 6 months after the children complete their 12 sessions of BPG training. We hypothesize that BPG dynamic assessment of learning loss at 6-month follow- up post-CCRT will be especially sensitive to integrity of brain/behavior function in pediatric HIV. Overall Impact: BPG will be the first CCRT validated for dual cognitive assessment, both static and dynamic. We expect BPG’s dynamic assessment capability will provide fundamental new insights into how HIV disease and treatment affects brain development, enabling sensitive and accessible cognitive measurement tools for clinical trials. BPG can also be an accessible and inexpensive assessment tool in resource-constrained settings to enable community health workers to monitor brain development in children burdened by other diseases and injuries. It can do so as a mobile-based tablet or smart phone device lending itself to easy scalability of language-free cognitive testing, which can be done as part of cognitive rehabilitation intervention.
在NIH的资助下,我们开发了BPG(脑动力游戏),CCRT(计算机认知游戏), 为撒哈拉以南地区艾滋病毒阳性的学龄儿童提供数字游戏包。就像一个孩子在玩耍, BPG将收集游戏数据进行神经认知评估。BPG已在艾滋病毒阳性儿童中进行了试点测试。 在研究目标1中,我们将评估同时和预测效度。在这里,我们将评估BPG静态 (基线)评估将很好地对应于我们的黄金标准静态测量(KABC-II,TOVA,CogState)。 与这些相比,我们假设动态BPG评估将提供更敏感的 评估受HIV暴露、疾病和其他更近端因素影响的脑/行为功能 治疗我们还假设动态评估对远端发育风险更敏感 因素(例如,SES、营养/生长、孕产妇生育质量)。 在研究目标2中,我们将比较BPG静态和动态评估的有效性。在这里,我们将验证 BPG静态和动态评估与金标准的神经心理学测试,以前使用 在我们的两个研究地点(乌干达的坎帕拉和马拉维的布兰太尔),5 - 12岁的儿童。孩子们将在3 队列:1)HIV阳性; 2)HIV暴露和未感染(HEU); 3)HIV未暴露和未感染(HUU)。 由于参与了我们以前的NIH赞助的HIV临床试验,队列将得到很好的表征。我们 假设基于BGP的静态和动态评估对队列先前的纵向 轨迹受到近端和远端风险因素的影响,导致发育迟缓和认知障碍。 问题,正如我们以前对这些队列的临床试验研究所测量的那样。 在研究目标3中,我们将测试训练结束后动态评估对学习损失的敏感性。一个 动态评估的优势应该是它对随着时间的推移学习损失的敏感性,作为衡量力量的标准 积极的神经可塑性在大脑/行为功能。在这里,我们将通过评估所有3个队列来测试敏感性 在儿童完成12个月后进行BPG和金标准测试(KABC-II,TOVA,CogState) BPG培训课程。我们假设BPG在6个月后对学习丧失的动态评估- CCRT后对儿童HIV的大脑/行为功能的完整性特别敏感。 总体影响:BPG将是第一个经验证可用于静态和动态双重认知评估的CCRT。 我们希望BPG的动态评估能力将为艾滋病毒疾病如何 和治疗影响大脑发育,使敏感和可访问的认知测量工具, 临床试验在资源有限的国家,生物多样性评估也是一种可获得和廉价的评估工具。 设置,使社区卫生工作者能够监测儿童的大脑发育, 疾病和伤害。它可以作为一个基于移动的平板电脑或智能手机设备, 无语言认知测试的可扩展性,这可以作为认知康复干预的一部分。

项目成果

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Michael Joseph Boivin其他文献

Michael Joseph Boivin的其他文献

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{{ truncateString('Michael Joseph Boivin', 18)}}的其他基金

Culture-specific neurodevelopmental assessment of HIV-affected children: Home-Based Evaluation through Cloud-Readiness Enhancement
对受艾滋病毒影响的儿童进行特定文化的神经发育评估:通过云准备增强进行家庭评估
  • 批准号:
    10598698
  • 财政年份:
    2022
  • 资助金额:
    $ 37.58万
  • 项目类别:
Culture–specific neurodevelopmental assessment of HIV-affected children
对受艾滋病毒影响的儿童进行文化特定的神经发育评估
  • 批准号:
    9893889
  • 财政年份:
    2019
  • 资助金额:
    $ 37.58万
  • 项目类别:
Culture–specific neurodevelopmental assessment of HIV-affected children
对受艾滋病毒影响的儿童进行文化特定的神经发育评估
  • 批准号:
    10358510
  • 财政年份:
    2019
  • 资助金额:
    $ 37.58万
  • 项目类别:
Caregiver Early Child Development Training for Preventing Konzo from Toxic Cassava in the DR Congo
刚果民主共和国的看护者早期儿童发展培训,以防止 Konzo 接触有毒木薯
  • 批准号:
    10017701
  • 财政年份:
    2019
  • 资助金额:
    $ 37.58万
  • 项目类别:
Culture–specific neurodevelopmental assessment of HIV-affected children
对受艾滋病毒影响的儿童进行文化特定的神经发育评估
  • 批准号:
    10584607
  • 财政年份:
    2019
  • 资助金额:
    $ 37.58万
  • 项目类别:
Developmental and Growth Outcomes for ARV Exposed HIV Uninfected African Children
暴露于抗逆转录病毒药物(ARV)、未感染艾滋病毒的非洲儿童的发育和生长结果
  • 批准号:
    8419654
  • 财政年份:
    2012
  • 资助金额:
    $ 37.58万
  • 项目类别:
Developmental and Growth Outcomes for ARV Exposed HIV Uninfected African Children
暴露于抗逆转录病毒药物(ARV)、未感染艾滋病毒的非洲儿童的发育和生长结果
  • 批准号:
    8705555
  • 财政年份:
    2012
  • 资助金额:
    $ 37.58万
  • 项目类别:
Developmental and Growth Outcomes for ARV Exposed HIV Uninfected African Children
暴露于抗逆转录病毒药物(ARV)、未感染艾滋病毒的非洲儿童的发育和生长结果
  • 批准号:
    8519501
  • 财政年份:
    2012
  • 资助金额:
    $ 37.58万
  • 项目类别:
Computerized Cognitive Rehabilitation in Children after Severe Malaria
严重疟疾后儿童的计算机认知康复
  • 批准号:
    8811141
  • 财政年份:
    2011
  • 资助金额:
    $ 37.58万
  • 项目类别:
Computerized Cognitive Rehabilitation in Children after Severe Malaria
严重疟疾后儿童的计算机认知康复
  • 批准号:
    8606482
  • 财政年份:
    2011
  • 资助金额:
    $ 37.58万
  • 项目类别:

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