Culture-specific neurodevelopmental assessment of HIV-affected children: Home-Based Evaluation through Cloud-Readiness Enhancement

在R01HD098027中，我们推出了基于非洲脑力游戏(BPG)平板电脑的游戏应用程序以供使用 在我们的坎帕拉、乌干达和马拉维布兰太尔研究诊所与感染艾滋病毒的儿童进行合作。BPG是一个套餐 的认知训练游戏最初在乌干达的HIV+学童中进行了临床测试(在NIH的支持下)。 当一个孩子玩耍时，BPG会收集游戏数据进行神经认知评估。在2020-2021年的封锁期间 与乌干达的新冠肺炎疫情有关，我们将业务流程规划会议从诊所转移到参与者的 家。开发云架构将允许我们更快地交付内容和接收数据，因为 云结构的分布式特性。如果我们可以管理神经认知训练应用程序请求 基于云的多服务器集成网络，非洲本地移动网络带宽受限可能 被绕过。实时数据请求可以扩展以满足需求，因此不会不堪重负 一台本地服务器。这是我们以计算机为基础的评估/康复的首要目标 在这项补充拨款的支持下，为处于危险中的非洲儿童提供的应用程序可以实现云就绪。学习目标1 我们将评估BPG和一个新开发的亲社会游戏的并发和预测有效性 推理和规划调用了Village Builder(VB)，以其他经过验证的基于计算机的测试电池为基础 神经认知功能的大脑/行为完整性指标。的补充开发活动 研究目标1.与我们的第一个研究目标最相关的软件开发活动是软件重构 高效地扩展到云端。云就绪咨询专家将与R01合作调查员和 BPG和VB应用程序开发人员Brian Winn教授将在他的“严肃游戏”中开发的应用 娱乐和学习“(Gel)实验室从LAMP(Linux、Apache、MySQL、PHP)Web堆栈到AWS或 其他云提供商。然后，我们将把当前用于基于Internet的数据收集的PHPAPI移到 REST API组件化应用程序。研究目标2的补充发展活动包括 提供标准源代码结构、文档、版本管理、构建和测试支持 在促进社区开源增强的代码库中。我们将使用这些配置工具来实现这一点 作为Git/GitHub，我们可以使用它来适应云的其他软件。温教授的凝胶实验室 程序员将使用JSON(JavaScript对象表示法)。大多数REST API和任何本机云 服务将使用JSON，因为我们的R01培训/评估应用程序(BPG和VB)将过渡到 此补充软件开发计划中的云就绪性。补充发展活动 对于研究目标3，将对BPG在日益增长的互联网环境下的可用性、互操作性和可扩展性进行初步测试 两个站点(乌干达和马拉维)的实时带宽。这些措施包括使用增强的硬件和 集群技术。结论。这一管理补充使我们能够有效地将 在孩子的家庭环境中，基于云到移动的互联网实时BPG和VB应用程序管理。

In R01HD098027 we have rolled out our Africa Brain Powered Games (BPG) tablet-based games app for use with HIV-affected children at our Kampala Uganda and Blantyre Malawi study clinic sites. BPG is a package of cognitive training games originally clinically tested (with NIH support) with HIV+ school children in Uganda. As a child plays, BPG gathers game data for neurocognitive assessment. During the lockdowns in 2020-2021 associated with COVID-19 outbreak in Uganda, we shifted BPG sessions from the clinic to the participant’s homes. Developing a cloud architecture would allow us to deliver content and receive data faster given the distributed nature of the cloud structure. If we could manage neurocognitive training app requests using the cloud-based integrated network of many servers, local mobile network bandwidth constraints in Africa could be circumvented. Real-time data requests could be scaled up to meet demand and therefore, not overwhelm a single local server. This is the overarching goal of making our computer-based assessment/rehabilitative apps with at-risk African children “cloud-ready” with the support of this supplemental grant. In Study Aim 1 we will evaluate concurrent and predictive validity of BPG and a newly developed prosocial game of reasoning and planning called Village Builder (VB) to other proven computer-based and testing battery indicators of brain/behavior integrity of neurocognitive function. Supplemental Development Activity for Study Aim 1. The software development activities most relevant to our 1st study aim is re-factoring software to scale efficiently to the cloud. Cloud-readiness consulting experts will work with R01 co-investigator and BPG and VB apps developer Professor Brian Winn to move the apps developed in his “serious games for entertainment and learning” (GEL) lab from the LAMP (Linux, Apache, MySQL, PHP) web stack to AWS or other cloud providers. We will then move our current PHP API used for internet-based data gathering to a REST API componentized application. Supplemental Development Activity for Study Aim 2 involves provisioning of standard source code structure, documentation, version management, build and test support in codebases that promotes community open-source enhancement. We will do so with such provisioning tools as Git/GitHub, that we have use for other software adaptations to the cloud. Prof. Winn’s GEL lab programmers will utilize JSON (JavaScript Object Notation). Most of the REST APIs and any native cloud services are going to utilize JSON as our R01 training/assessment apps (BPG and VB) are transitioned for cloud readiness in this supplemental software development initiative. Supplemental Development Activity for Study Aim 3 will pilot test the usability, interoperability and scalability of BPG under increasing internet real-time bandwidth at both sites (Uganda and Malawi). These include making use of enhanced hardware and clustering technology. Conclusion. This administrative supplement allows us to effectively interfacing the cloud to mobile-based internet real-time BPG and VB app management in the child’s home environment.