Metabotropic glutamate receptors: pharmacological studies of receptor subtypes in neuronal injury.

代谢型谷氨酸受体：神经元损伤中受体亚型的药理学研究。

• 批准号: nhmrc : 194320
• 负责人: Prof Philip Beart
• 金额: $ 9.72万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/metabotropic-glutamate-receptors-neuronal-injury/94840
• 关键词: Metabotropic; glutamate; receptors; pharmacological; studies

Glutamate is the major transmitter of excitatory information in the mammalian brain. Disruption of glutamate-mediated signaling between brain cells results in high extracellular levels of glutamate which is toxic to neurones. A recently discovered family of signal transducers, the metabotropic glutamate receptors, has been found to be localized on neurones and is switched on by these toxic glutamate levels. The roles of these metabotropic glutamate receptors in neurotoxicity is essentially unexplored and is the topic under investigation in this project. How their activation affects cellular signaling switch on will be investigated to gain an understanding of the roles metabotropic glutamate receptors play in acute brain injury (eg stroke) and chronic neurodegenerative conditions (eg Huntington's chorea and Alzheimer's disease).

谷氨酸是哺乳动物大脑中兴奋信息的主要传递者。破坏谷氨酸介导的脑细胞间信号传递会导致细胞外高水平的谷氨酸，这对神经元是有毒的。最近发现的一个信号转导家族，代谢性谷氨酸受体，被发现定位在神经元上，并被这些有毒的谷氨酸水平激活。这些代谢性谷氨酸受体在神经毒性中的作用基本上是未知的，这是本项目正在调查的主题。为了了解代谢型谷氨酸受体在急性脑损伤(如中风)和慢性神经退行性疾病(如亨廷顿舞蹈病和阿尔茨海默病)中所起的作用，将研究它们的激活如何影响细胞信号开关。