KSHV IMMUNE EVASION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 卡波西肉瘤相关疱疹病毒(KSHV)一直与卡波西肉瘤(KS)、原发性渗出性淋巴瘤(PEL)和多中心卡特勒曼病(MCD)的发病机制有关。KSHV感染的特点是建立终身持久性，这给这种病毒施加了巨大的压力，使其逃脱宿主的免疫识别。尽管许多机制细节需要进一步阐明，但KSHV将其基因组的很大一部分致力于基因产物，这些基因产物共同破坏宿主免疫系统的几乎每个方面。对这些策略的更透彻的理解有助于揭开病毒发病机制的复杂性，并可能揭示新的治疗策略的靶点。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Kaposi's sarcoma associated herpesvirus (KSHV) has been consistently implicated in the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric casttleman's disease (MCD). The hallmark of KSHV infection is to establish life-long persistency that has imposed enormous pressure on this virus to escape host immune recognition. Although many of the mechanistic details require further elucidation, KSHV devotes a significant portion of its genome to gene products that together sabotage almost every aspect of host's immune system. A more thorough understanding of these strategies helps to unravel the complexities of viral pathogenesis and may reveal targets for novel therapeutic strategies.