Supplemental Funding Request for RF1 AG062309 Early life glycemic status and Alzheimer's disease neuroimaging markers in middle age: the Bogalusa Heart Study

父母研究(R01AG062309)检查了寿命之间的关联 心脏代谢暴露与中年大脑结构和功能以及中年 认知功能，在博加卢萨半乡村混血心脏研究(BHS)中。这个 主要研究的重要性在于，它澄清了哪些心脏代谢暴露 对社会经济上不同的非裔美国人和 认知年龄段(50年代和60年代初)的白人个体 大脑健康开始变得更加多样化，并开始包括临床上的- 许多人的认知能力明显下降。本副刊增加了三个 我们将检查的一组暴露的额外心脏代谢暴露：突然 新冠肺炎导致的体力活动、饮食质量和睡眠质量的降低 居家禁闭。BHS参与者将接受相同的饮食、体力活动、 以及睡眠问卷，在他们之前的每次BHS研究访问中进行评估，以及 一项专门为识别Covid19相关变化而设计的新调查。有一个 评估这种与分娩相关的生活方式突然改变的时间迫在眉睫： BHS参与者现在被限制在家里，因此能够评估他们的 现在改变自己与分娩相关的生活方式，而不是依赖于容易出错的回忆 远端事件。该附录通过提供数据显著增强了家长研究 正是这种突发的、由事件驱动的心脏代谢变化是重要的 对长期结果的影响，但通常被纵向队列研究忽略，如 BHS，其结构适合测量过程中缓慢变化的变化 很多年了。这种补充剂可以澄清这种生活方式突然改变的重要性 为了长期的健康，相对于这种缓慢的时变变化。在这样做时， 补充可以阐明快速部署生活方式干预措施的重要性 呆在家里的个人，以支持高饮食质量，体力活动， 以及在未来大流行的情况下的睡眠质量。

The parent study (R01AG062309) examines associations between lifespan cardiometabolic exposures and midlife brain structure and function, as well as midlife cognitive function, in the bi-racial, semi-rural Bogalusa Heart Study (BHS). The importance of the main study is that it clarifies which cardiometabolic exposures influence the brain health of a socioeconomically diverse group of African American and white individuals at the portion of the lifespan (the 50s and early 60s) when cognitive and brain health begins to become more heterogeneous and begins to include clinically- significant cognitive decline in a large number of persons. This supplement adds three additional cardiometabolic exposures to the set of exposures we will examine: sudden reductions in physical activity, diet quality, and sleep quality caused by Covid-19 related home confinement. BHS participants will receive the same set of diet, physical activity, and sleep questionnaires that are assessed at each of their prior BHS study visits, along with a new survey specifically designed to identify Covid19-related changes. There is an extreme time urgency to assessing such confinement-related sudden lifestyle changes: BHS participants are confined to the home now, and are therefore able to assess their own confinement-related lifestyle changes now, rather than rely on error-prone recall of distal events. The supplement significantly enhances the parent study by providing data on exactly the sort of sudden, event-driven cardiometabolic changes that are important to long-term outcomes, but are typically missed by a longitudinal cohort study such as BHS, whose structure lends itself to measuring slowly-varying changes over the course of years. The supplement could clarify the importance of such sudden lifestyle changes to long-term health, relative to such slowly time-varying changes. In so doing, the supplement could clarify the importance of rapidly deploying lifestyle interventions to home-confined individuals to support high diet quality, physical activity attainment, and sleep quality in the event of a future pandemic.