FLOW EFFECTS OF ENDOTHELIAL/TROPHOBLAST INTERACTION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 目的： 1.描述切应力对滋养层细胞定向迁移的影响 2.确定趋化因子和内皮粘附分子在剪切应力介导的滋养层细胞迁移中的作用。 3.确定切应力和滋养层-内皮细胞相互作用对诱导迁移性滋养层表型的影响。 4.描述CCR 5、RANTES、蛋白多糖和整合素在受侵猕猴子宫血管中的表达。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objectives: 1. Characterize the effect of shear stress on the directional migration of trophoblast cells 2. Determine the role of chemokines and endothelial adhesion molecules in shear stress-mediated trophoblast migration. 3. Determine the effect of shear stress and trophoblast-endothelial cell interaction on the induction of a migratory trophoblast phenotype. 4. Characterize the expression of CCR5, RANTES, proteoglycans, and integrins in invaded macaque uterine vessels.