FLOW EFFECTS OF ENDOTHELIAL/TROPHOBLAST INTERACTION

内皮细胞/滋养层相互作用的血流效应

• 批准号: 7959003
• 负责人: GORDON C DOUGLAS
• 金额: $ 7.12万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959003
• 关键词: California; Computer Retrieval of Information on Scientific Projects Database; Endothelium; Funding; Grant; Institution; Integrins; Mediating; Mucin-1 Staining Method; Phosphorylation; Primates; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Up-Regulation; cell motility; trophoblast

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of this project are: 1) Does FSS-induced upregulation of trophoblast ¿1 integrin expression and cell migration on endothelium depend on ErbB-mediated phosphorylation of MUC1? 2) Does FSS-mediated upregulation of trophoblast ¿1 integrin expression and migratory activity require direct interaction between MUC1 and ERs? 3) Does FSS-induced upregulation of trophoblast ¿1 integrin expression and migratory activity depend on MUC1-mediated phosphorylation of ERs? 4) Does MUC1 modulate ER function under FSS conditions by regulating the intracellular localization of ERs? 5) Determine whether MUC1 responds to directly applied force

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 该项目的目标是： 1）FSS诱导的滋养细胞上调»1整联蛋白的表达和森林上的细胞迁移取决于MUC1的ERBB介导的磷酸化？ 2）FSS介导的滋养细胞的上调»整合素表达和迁移活性需要MUC1与ERS之间的直接相互作用吗？ 3）FSS诱导的滋养细胞的上调是否取决于MUC1介导的ER的磷酸化？ 4）在FSS条件下，MUC1是否通过反思ER的细胞内定位来调节ER功能？ 5）确定MUC1是否响应直接施加力