CHARACTERIZATION OF EPILEPSY IN THE PEDIGREED BABOONS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在人类和动物中，癫痫有许多不同的分类。 癫痫发作和癫痫的分类需要详细的临床病史和与发作间期（发作之间）脑电图（EEG）的相关性。 在动物中，为了进一步表征癫痫发作类型，需要仔细观察癫痫发作和频率。 SFBR的纯种狒狒中报告自发性癫痫发作已超过15年。 癫痫发作发生在没有任何明显的神经病理学，毒性或代谢异常，但癫痫发作的类型和频率还没有得到很好的表征。 癫痫发作的频率太低，不值得持续观察或监测。 然而，不同类型的癫痫具有不同的EEG模式。 这些脑电图的信息可以在清醒的癫痫个体中获得和研究，该个体在检查期间没有临床癫痫发作活动。在易感动物中，间歇性光刺激（光刺激）也可以诱导癫痫发作的临床表现。 使用光刺激和EEG记录的组合来表征癫痫类型的癫痫狒狒的初步调查证明了3种不同的癫痫类型。 这些动物代表了遗传性癫痫的独特动物模型。 从临床和遗传学的角度来看，它们将有助于研究人类癫痫和测试用于治疗癫痫的新药。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In humans and animals, there are many different classifications of epilepsy. The classification of seizures and epilepsy requires a detailed clinical history and correlation with interictal (between seizure) electroencephalography (EEG). In animals, to further characterize the seizure types, a careful observation of the seizures and the frequency is required. Spontaneous seizures have been reported in the pedigreed baboons at SFBR for over 15 years. The seizures have occurred in the absence of any overt neuropathologic, toxic or metabolic abnormalities, but the seizure types and frequency have not been well characterized. The seizures occur too infrequently to warrant continuous observation or monitoring. Different types of epilepsy, however, have distinctive EEG patterns. The information from these EEGs can be obtained and studied in an awake epileptic individual that is not having clinical seizure activity during the exam. Also intermittent light stimulation (photostimulation) can, in predisposed animals, induce clinical manifestations of epilepsy, seizures. A preliminary survey of the epileptic baboons using a combination of photostimulation and EEG recordings to characterize the type of epilepsy has demonstrated 3 distinct epileptic types. These animals represent a unique animal model for inherited epilepsy. From a clinical and genetic standpoint they will be useful to study epilepsy in humans and to test new drugs used to treat epilepsy.