CHARACTERIZATION OF EPILEPSY IN THE PEDIGREED BABOONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在人类和动物中，癫痫有许多不同的分类。癫痫和癫痫的分类需要详细的临床病史以及与发作间期(发作间期)脑电(EEG)的相关性。在动物中，为了进一步确定癫痫发作的类型，需要仔细观察癫痫发作和发作频率。15年来，SFBR一直有自发性癫痫发作的报道。癫痫发作发生在没有任何明显的神经病理、毒性或代谢异常的情况下，但癫痫发作的类型和频率尚未得到很好的描述。癫痫发作发生的频率太低，不值得继续观察或监测。然而，不同类型的癫痫有不同的脑电模式。来自这些脑电的信息可以在清醒的癫痫患者中获得并研究，该患者在检查期间没有临床癫痫发作活动。此外，间歇性光刺激(光刺激)对易患此病的动物可引起癫痫、癫痫的临床表现。一项使用光刺激和脑电记录相结合的方法对癫痫狒狒进行的初步调查表明，癫痫的类型有三种不同的类型。这些动物代表了一种独特的遗传性癫痫动物模型。从临床和遗传学的角度来看，它们将有助于研究人类的癫痫，并测试用于治疗癫痫的新药。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In humans and animals, there are many different classifications of epilepsy. The classification of seizures and epilepsy requires a detailed clinical history and correlation with interictal (between seizure) electroencephalography (EEG). In animals, to further characterize the seizure types, a careful observation of the seizures and the frequency is required. Spontaneous seizures have been reported in the pedigreed baboons at SFBR for over 15 years. The seizures have occurred in the absence of any overt neuropathologic, toxic or metabolic abnormalities, but the seizure types and frequency have not been well characterized. The seizures occur too infrequently to warrant continuous observation or monitoring. Different types of epilepsy, however, have distinctive EEG patterns. The information from these EEGs can be obtained and studied in an awake epileptic individual that is not having clinical seizure activity during the exam. Also intermittent light stimulation (photostimulation) can, in predisposed animals, induce clinical manifestations of epilepsy, seizures. A preliminary survey of the epileptic baboons using a combination of photostimulation and EEG recordings to characterize the type of epilepsy has demonstrated 3 distinct epileptic types. These animals represent a unique animal model for inherited epilepsy. From a clinical and genetic standpoint they will be useful to study epilepsy in humans and to test new drugs used to treat epilepsy.