MULTIMODAL EVALUATION OF PHOTOSENSITIVE EPILEPSY IN BABOONS

狒狒光敏性癫痫的多模式评估

• 批准号: 8172727
• 负责人: akos szabo
• 金额: $ 4.05万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172727
• 关键词: Antiepileptic Agents; Biological; Computer Retrieval of Information on Scientific Projects Database; Data Analyses; Development; Epilepsy; Equation; Evaluation; Exploratory/Developmental Grant; Funding; Generalized Epilepsy; Generations; Goals; Grant; Human; Implanted Electrodes; Institution; Intervention; Light; Microelectrodes; Modeling; Motor; Papio; Parents; Pharmaceutical Preparations; Photosensitive Epilepsy; Regional Blood Flow; Research; Research Personnel; Research Project Grants; Resources; Source; Transcranial magnetic stimulation; United States National Institutes of Health; Visual Cortex; implantation; neuroimaging; response; visual motor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study titled "Multimodal Evaluation of Networks Underlying Photosensitive Epilepsy in Baboons" is being submitted as a NIH Exploratory/Developmental Research Grant Program (R21 Parent) for review (PA-06-181). The mechanisms underlying generalized epilepsy in humans are still unknown. The objective of this study is to correlate regional blood flow changes identified by functional neuroimaging with spontaneous epileptic discharges and photoepileptic responses recorded by intracranially implanted electrodes, with the eventual goal of identifying in networks underlying the photosensitive generalized epilepsy of the baboon. We will also utilize transcranial magnetic stimulation in addition to intermittent light stimulation to evaluate the respective contribution of motor and visual cortex activations to the epileptic networks. This study will generate preliminary data for the analysis of visual and motor connectivity in photosensitive and healthy baboons using structural equation modeling. It will also determine candidate regions responsible for the generation of spontaneous epileptic discharges and photoepileptic responses for subdural grid or microelectrode array implantation. With a multimodal approach, we aim to develop a model for photosensitive generalized epilepsy which can be implemented for the evaluation of the biological effects of new antiepileptic medications or neurosurgical interventions.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项名为“狒狒光敏性癫痫网络基础的多模式评价”的研究正在作为NIH探索性/发展性研究资助计划（R21 Parent）提交审查（PA-06-181）。人类全身性癫痫的潜在机制仍然未知。本研究的目的是相关的区域血流变化与自发性癫痫放电和颅内植入电极记录的光致癫痫反应的功能性神经影像学，最终目标是确定在网络的狒狒光敏全身性癫痫。除了间歇性光刺激外，我们还将利用经颅磁刺激来评估运动和视觉皮层激活对癫痫网络的各自贡献。本研究将使用结构方程模型生成用于分析光敏和健康狒狒的视觉和运动连接的初步数据。它还将确定负责产生自发性癫痫放电和光癫痫反应的候选区域，用于硬膜下网格或微电极阵列植入。通过多模式方法，我们的目标是开发一种光敏全身性癫痫模型，该模型可用于评价新的抗癫痫药物或神经外科干预的生物学效应。