Metallo-beta-lactamases: predicting and combating antibiotic resistance

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The increase of drug-resistant bacterial pathogens has become a major global health concern. Many pathogens employ a special enzyme, named metallo-beta-lactamase (MBL), to degrade antibiotics such as penicillin. No clinically useful inhibitors of this enzyme are available. We will use sophisticated techniques to predict and combat drug resistance of the MBL from Klebsiella pneumoniae, a pathogen associated in particular with hospital-acquired infections such as urinary tract infections.