Non-viral vectors for targeted delivery of RNAi nucleotides to cervical cancers

用于将 RNAi 核苷酸靶向递送至宫颈癌的非病毒载体

• 批准号: nhmrc : 455890
• 负责人: A/Pr Ross Mcgeary
• 金额: $ 27.72万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/non-viral-vectors-cervical-cancers/77900
• 关键词: Non; viral; vectors; targeted; delivery

RNA interference (or gene silencing) is a new technique whereby we are able to turn off the expression of a particular gene either temporarily or permanently. Cancer is basically a genetic disease where certain protective genes are lost or cancer-causing genes expressed. Gene silencing holds great promise in the treatment of genetic disorders, infectious diseases and cancer. Cervical cancer is caused by infection with the human papillomavirus and the expression of two cancer-causing genes. Using RNA interference we can turn off the expression of these two genes which results in the death of the cancer cell. We are also able to cure mice of tumours derived from human cervical cancer. The major issue with gene silencing is how to deliver it effectively to patients. Here we are investigating novel nanoparticulate systems to deliver this new gene-inhibiting drugs preferentially to the tumour site.

RNA干扰（或基因沉默）是一种新技术，我们可以暂时或永久地关闭特定基因的表达。癌症基本上是一种遗传疾病，其中某些保护基因丢失或致癌基因表达。基因沉默在遗传疾病、传染病和癌症的治疗中具有巨大的前景。宫颈癌是由人乳头瘤病毒感染和两种致癌基因的表达引起的。使用RNA干扰，我们可以关闭这两个基因的表达，导致癌细胞死亡。我们还能够治愈小鼠的人类宫颈癌肿瘤。基因沉默的主要问题是如何将其有效地传递给患者。在这里，我们正在研究新的纳米颗粒系统，将这种新的基因抑制药物优先输送到肿瘤部位。