IMMUNOGENICITY OF HIV CANDIDATE VACCINES IN BABOONS

HIV 候选疫苗对狒狒的免疫原性

• 批准号: 7562492
• 负责人: KRISHNA H MURTHY
• 金额: $ 2.17万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562492
• 关键词: AIDS Vaccines; Acquired Immunodeficiency Syndrome; Computer Retrieval of Information on Scientific Projects Database; Drug Formulations; Funding; Grant; HIV; Human; Institution; Modeling; Numbers; Papio; Prevention; Range; Relative (related person); Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; Vaccines; Virus; immunogenicity; killings; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human immunodeficiency virus (HIV) was identified as the causative agent of AIDS more then 21 years ago and the virus has killed approximately 23 million people and is estimated to have infected nearly 46 million people worldwide. No effective vaccine is available for prevention of further spread of the virus. In this proposal, we will examine the immunogenicity of novel candidate AIDS vaccines in the baboon model to hopefully identify a suitable vaccine formulation for human trials. A total of 60 baboons are requested for the proposed project. Groups of 8 to 12 baboons will be used for testing the immunogenicity of different candidate vaccines. We plan to use 8 to 12 baboons for testing the immunogenicity of each candidate vaccine at 6 to 8 month intervals. Therefore, the total number of vaccine candidates tested will range from 5-7. The experimental objective for the entire proposal is to evaluate the relative immunogenicity of different vaccine candidates.

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