HORMONE ASSAY % ANALYTICA SERVICES CORE

激素%20测定%20%%20分析%20服务%20核心

• 批准号: 7284643
• 负责人: Alan D Cherrington
• 金额: $ 26.83万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7284643
• 关键词: Advisory Committees; Automation; Back; Biological Assay; Blood; Blood Plasma Volume; Canis familiaris; Catecholamines; Charge; Contract Services; Diabetes Mellitus; Endocrine; Endocrinology; Equipment; Family suidae; Fees; Funding; Glucagon; Grant; Growth; Hormones; Human; Human Resources; Hydrocortisone; Insulin; Leptin; Liquid substance; Maintenance; Measurement; Measures; Metabolic; Methods; Mus; Numbers; Operative Surgical Procedures; Pancreatic Polypeptide; Peptides; Physiology; Program Evaluation; Rate; Reagent; Research; Research Personnel; Rodent; Sampling; Services; Somatotropin; Surveys; Technology; Testing; Validation; assay development; cost; design; glucagon-like peptide 1; improved; method development; quality assurance

The Hormone Assay Core assists investigators in the measurement of hormones in biologic fluids as related to diabetes, endocrine and metabolic research. The core provides space, equipment, and personnel for sample analysis and method development. User charge backs support the cost of reagents, supplies and pro-rated service contracts. The analysis available include 1) insulin, 2) free insulin, 3) glucagon, 4) cortisol, 5) catecholamines, 6) growth hormone, 7) c-peptides (human, canine, porcine), 8) pancreatic polypeptides, 9) leptin, 10) ratcorticosterone, and 11) GLP-1 (active). Several of these assays are available in "micro" methods for the analysis of hormone levels in very small volumes of plasma or blood. Furthermore, some assays are designed to measure hormones in a particular species. The core has the potential to develop new tests and technologies to expand the scope of its current testing. An annual survey is conducted to determine the needs of users for new assays. Over the past grant period, there has been an increased demand for at least half of the services offered and a constant demand for the remainder. The core will be expanded to meet an expected growth in demand that is anticipated as a result of funding of a Murine Metabolic and Physiology Center. An advisory Committees will deal with issues of coordination between the DRTC and MMPC, as well as user fees and new service implementation.

荷尔蒙分析核心协助研究人员测量相关生物液中的荷尔蒙 糖尿病、内分泌和代谢研究。核心提供空间、设备和人员，为 样品分析和方法开发。用户按存储容量使用计费支持试剂、用品和 按比例计价的服务合同。可用的分析包括1)胰岛素，2)游离胰岛素，3)胰高血糖素，4) 皮质醇，5)儿茶酚胺，6)生长激素，7)C-肽(人、狗、猪)，8)胰腺 多肽，9)瘦素，10)大鼠皮质酮，和11)GLP-1(活性)。其中有几种检测方法是可用的 在“微量”方法中，用于分析极少量血浆或血液中的激素水平。 此外，有些检测方法是用来测量特定物种的荷尔蒙的。核心具有 有潜力开发新的测试和技术，以扩大其目前测试的范围。年度调查 是为了确定用户对新化验的需求。在过去的授权期内，有一个 对至少一半提供的服务的需求增加，对其余服务的需求持续增加。其核心是 将进行扩展，以满足预期的需求增长，这预计是资助一只老鼠的结果 代谢和生理中心。一个咨询委员会将处理以下问题： DRTC和MMPC，以及用户资费和新业务实施。