NIAMS Multidisciplinary Clin Res Ctr: Rheumatic Diseases

拟议的多学科临床研究中心(MCRC)是 多用途关节炎的流行病学-教育/卫生服务研究部分 北方大学瑟斯顿关节炎研究中心肌肉骨骼疾病中心 在教堂山的卡罗莱纳。该中心拥有一大批经验丰富的研究人员和管理人员， 与医学院、公共卫生、牙科、药房和护理学院以及 内科、儿科、骨科、家庭医学、社会医学、放射科、 流行病学、健康行为与健康教育、健康政策与管理、生物统计学。 MCRC的目标是1)在各种不同领域进行严格的跨学科临床研究 肌肉骨骼状况；2)指导方法学核心，以支持方法学、分析学和 获得资助的项目和其他未来项目的统计需求；以及3)促进新的 关节炎和肌肉骨骼疾病的研究思路和新研究项目的资助。为了 为了实现这些目标，拟议的MCRC将包括一个方法学核心、三个临床项目和一个 管理核心。方法论核心将构成中心的基础，并将为 以下职能：1)方法学和生物统计学咨询和审查；2)测量 3)数据支持服务，包括数据收集、数据管理和分析；4)数据和 安全监控；5)教学。提出的三个项目是：1)金属在骨关节炎中的作用 在多族裔农村人口中(首席调查者：乔安妮·乔丹博士)；2)个人和 关节炎结局的社区社会决定因素(首席调查者：Leigh Callahan博士)；以及 3)脉管炎患者及其家属的社会支持、控制感和心理适应 合作伙伴(首席调查员：Robert DeVellis博士)。这些项目包括流行病学和 针对不同患者群体的生物行为方法：北方一个特定农村社区的骨关节炎 卡罗莱纳；北卡罗来纳州社区家庭实践中的关节炎；以及小血管 东南部地区的训练所致的脉管炎。每个项目都是创新的，并解决了 很少或从未在关节炎和风湿性疾病的背景下进行检查。该地区的共同主题 对每个项目的调查都是对个人领域以外的影响和问题的调查。在第一个 在项目中，环境暴露是个人之外的力量。在第二个项目中，重点是 一个人所在社区的社会经济地位对关节炎结果的影响。最后， 个人和他/她的配偶的互动是第三个项目调查的重点。A管理人员 CORE将向该中心提供财政和科学监督和指导，并将由 主任、副主任、执行委员会和支助工作人员。

The proposed Multidisciplinary Clinical Research Center (MCRC) is a natural outgrowth of the Epidemiology_ducation/Health Services Research Component of the Multipurpose Arthritis and Musculoskeletal Diseases Center of the Thurston Arthritis Research Center at the University of North Carolina at Chapel Hill. The center has a large cadre of experienced researchers and administrators with direct linkages to the Schools of Medicine, Public Health, Dentistry, Pharmacy, and Nursing and to the Departments of Medicine, Pediatrics, Orthopaedics, Family Medicine, Social Medicine, Radiology, Epidemiology, Health Behavior and Health Education, Health Policy and Administration, and Biostatistics. The objectives of the MCRC are 1) to conduct rigorous interdisciplinary clinical research in a variety of musculoskeletal conditions; 2) to direct a Methodology Core to support the methodological, analytical, and statistical needs of the funded projects and other future projects; and 3) to foster the development of new research ideas and the funding of new research projects in arthritis and musculoskeletal diseases. In order to achieve these goals, the proposed MCRC will consist of a Methodology Core, three clinical projects, and an Administrative Core. The Methodology Core will form the foundation of the Center and will serve the following functions: 1) methodological and biostatistical consultation and review; 2) measurement development; 3) data support services including data collection, data management, and analysis; 4) data and safety monitoring; and 5) teaching. The three proposed projects are 1) The role of metals in osteoarthritis in a multi-ethnic, rural population (Principal Investigator: Dr. Joanne Jordan); 2) Individual and Community Social Determinants of Arthritis Outcomes (Principal Investigator: Dr. Leigh Callahan); and 3) Social support, perceived control, and psychological adjustment in vaseulitis patients and their partners (Principal Investigator: Dr. Robert DeVellis). The projects include epidemiologic and biobehavioral approaches to distinct patient populations: osteoarthritis in a specific rural community in North Carolina; arthritis in community family practices spanning the state of North Carolina; and small vessel vasculitis from practices across the Southeast. Each project is innovative and addresses issues which have rarely or never been examined in the context of arthritis and rheumatic diseases. A common theme to the area of inquiry of each project is that of influences and issues outside the realm of the individual. In the first project, environmental exposures are the forces outside the individual. In the second project, the focus is the impact of the socioeconomic status of the community in which one lives upon arthritis outcomes. Finally, the interaction of the individual and his/her spouse is the focus of inquiry of the third project. An Administrative Core will provide financial and scientific oversight and direction to the Center and will be composed of a Director, an Associate Director, an Executive Committee, and support staff.