NIAMS Multidisciplinary Clin Res Ctr: Rheumatic Diseases

建议的MCRC继续在ESTA的长期目标是了解的原因， 各种肌肉骨骼疾病，并确定适当的干预措施和有效的手段，以提供 他们，治疗和预防风湿性疾病及其后果。本申请建议1） 在骨关节炎（OA）、类风湿性关节炎（RA）和 患者报告的关节炎结局; 2）支持四项拟议研究的方法学和统计学需求 项目和未来的项目; 3）促进关节炎新研究的发展， 肌肉骨骼疾病作为中心的基础，方法论核心将提供：1） 方法学/生物统计学咨询; 2）测量开发; 3）数据支持服务; 4）数据 安全监管; 5）教育。这四个项目最大限度地提高了现有研究的效率和影响 以最小的额外成本。项目1，金属接触在慢性乙型肝炎严重程度和进展中的作用 全身性OA（主要研究者[PI]：Joanne Jordan博士），检查金属和OA生物标志物， 约翰斯顿县骨关节炎项目中的泛发性OA;项目2，个人和社区社会 非裔美国人RA结局的决定因素（PI：Leigh卡拉汉博士），检查了个体和 结果的社区决定因素，特别是隔离和感觉到的歧视， 美国RA患者在非裔美国人早期RA纵向评估联盟 风湿性关节炎;项目3，将现代测量方法应用于 关节炎研究（PI：Dr. Robert DeVellis），利用NIH Roadmap患者报告结局信息 系统（PROMIS）和其他关节炎数据集，以评估和改善关节炎患者的心理测量特性。 广泛用于关节炎研究的心理社会措施;和项目4，沟通与关节炎相关的风险 处方药（PI：Susan Blalock博士），检查患者与医生之间的药物沟通 RA患者的风险，利用来自NIA资助的研究老年人和药物决策的数据。的 项目使用流行病学和生物行为学的方法，以患者群体在OA，RA，和一般 通过识别OA和RA的新风险因素，改善风湿性疾病， 改善结果测量，并改善有关药物风险的沟通。

The long-term objectives of this proposed MCRC continuation at UNC are to understand the causes of a variety of musculoskeletal conditions and to identify appropriate interventions and effective means to deliver them, to treat and prevent rheumatic diseases and their consequences. This application proposes 1) to conduct rigorous interdisciplinary clinical research in osteoarthritis (OA), rheumatoid arthritis (RA) and patient-reported arthritis outcomes; 2) to support the methodological and statistical needs of four proposed projects and future projects; and 3) to foster the development of new research in arthritis and musculoskeletal diseases. As the foundation of the Center, the Methodology Core will provide: 1) methodological/ biostatistical consultation; 2) measurement development; 3) data support services; 4) data and safety monitoring; and 5) education. The four projects maximize efficiency and impact of extant studies for minimal additional cost. Project 1, The role of metals exposure in the severity and progression of generalized OA (Principal Investigator [PI]: Dr. Joanne Jordan), examines metals and OA biomarkers and generalized OA in the Johnston County Osteoarthritis Project; Project 2, Individual and community social determinants of outcomes in RA in African Americans (PI: Dr. Leigh Callahan), examines individual and community determinants of outcome, particularly segregation and perceived discrimination, in African Americans with RA in the Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis; Project 3, Applying modern measurement approaches to psychosocial variables in arthritis research (PI: Dr. Robert DeVellis), utilizes the NIH Roadmap Patient Reported Outcome Information Systems (PROMIS) and other arthritis datasets to assess and improve psychometric properties of psychosocial measures widely used in arthritis research; and Project 4, Communicating risks associated with prescription medications (PI: Dr. Susan Blalock), examines patient-physician communication of medication risks in patients with RA, utilizing data from the NIA-funded study Older adults and drug decisions. The projects use epidemiologic and bio-behavioral approaches to patient populations in OA, RA, and general rheumatologic conditions to advance the public health by identifying novel risk factors for OA and RA, improving outcome measurement, and improving communication about medication risks.