Lymphoid neogenesis and CD4+T cell differentiation in primary Sjogren's syndrome

原发性干燥综合征中的淋巴新生和 CD4 T 细胞分化

基本信息

  • 批准号:
    7687681
  • 负责人:
  • 金额:
    $ 25.49万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-05-01 至 2014-04-30
  • 项目状态:
    已结题

项目摘要

Primary Sjogren's syndrome (pSS) is a systemic chronic inflammatory autoimmune disease characterized by dry eyes and dry mouth. Essential histopathologic features of pSS include focal infiltrations of T and B cells in the salivary and lacrimal glands that lead to tissue injury and chronic inflammation. In some cases, the histopathologic changes develop into tertiary lymphoid tissues or organs (TLs) via a process called lymphoid neogenesis. TLOs resemble spleen and lymph nodes in their cellular composition and organization. TLOs may serve as a place where recruitment of T cells with lymphoid homing capacity (naive and central memory cells) as well as their activation, proliferation and differentiation occur. CD4+ T cells that orchestrate immune responses can be divided into T-helper (Th)1, Th2 and Th17 cells as well as CD4+ T cells with regulatory function including forkhead box P3 (FOXP3)-positive regulatory T cells (Treg). Although T cells and their cytokines are found in the salivary tissues of pSS, it is unknown which type of T cells has a leading role in the pathogenesis. This project investigates the hypothesis that patients with pSS have an altered balance of Th17 and Treg immune responses that is caused by chronic inflammation with lymphoid neogenesis and defect(s) in differentiating and functioning of Th17 cells and Treg based on the facts that Th17 cells potently induce inflammation while Treg suppress it. Plus, the both cell types are linked with autoimmunity and have a reciprocal relationship in cellular differentiation under inflammatory milieu. The hypothesis will be addressed with: 1) Aim 1. Determine if the TLOs in pSS could serve as sites of antigen presentation for induction of autoantibodies, tolerance or activation, focusing on Treg and Th17 cells; 2) Aim 2. Determine if patients with pSS have an altered balance of Th17 and Treg immune responses in the peripheral blood secondary to a defect(s) in Th17 cells and Treg differentiation and function; and 3) Aim 3. Determine if the altered balance of Th17 and Treg immune responses in peripheral blood correlates with TLOs in the fresh minor salivary tissues in patients with pSS. These studies will shed new light on the pathogenesis and treatment of autoimmune diseases including pSS.
原发性干燥综合征(pSS)是一种全身性慢性炎症性自身免疫性疾病

项目成果

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Insoo Kang其他文献

Insoo Kang的其他文献

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{{ truncateString('Insoo Kang', 18)}}的其他基金

Investigating monocyte activation pathways in lupus
研究狼疮中的单核细胞激活途径
  • 批准号:
    10731104
  • 财政年份:
    2023
  • 资助金额:
    $ 25.49万
  • 项目类别:
Studying alterations of T cell immune responses in the 17q12 deletion syndrome
研究 17q12 缺失综合征中 T 细胞免疫反应的变化
  • 批准号:
    10518405
  • 财政年份:
    2021
  • 资助金额:
    $ 25.49万
  • 项目类别:
Studying alterations of T cell immune responses in the 17q12 deletion syndrome
研究 17q12 缺失综合征中 T 细胞免疫反应的变化
  • 批准号:
    10391990
  • 财政年份:
    2021
  • 资助金额:
    $ 25.49万
  • 项目类别:
Studying the impact of altered CD8+ T cell immunity in Alzheimer's disease
研究 CD8 T 细胞免疫改变对阿尔茨海默病的影响
  • 批准号:
    10119925
  • 财政年份:
    2018
  • 资助金额:
    $ 25.49万
  • 项目类别:
Aging and IL-7 mediated CD8+ T cell survival
衰老和 IL-7 介导的 CD8 T 细胞存活
  • 批准号:
    10443824
  • 财政年份:
    2018
  • 资助金额:
    $ 25.49万
  • 项目类别:
Aging and IL-7 mediated CD8+ T cell survival
衰老和 IL-7 介导的 CD8 T 细胞存活
  • 批准号:
    10207438
  • 财政年份:
    2018
  • 资助金额:
    $ 25.49万
  • 项目类别:
Aging and IL-7 mediated CD8+ T cell survival
衰老和 IL-7 介导的 CD8 T 细胞存活
  • 批准号:
    9764233
  • 财政年份:
    2018
  • 资助金额:
    $ 25.49万
  • 项目类别:
The Impact of Aging and HIV Infection on Immunologic and Transcriptomic Signatures of Influenza Vaccine Response
衰老和 HIV 感染对流感疫苗反应的免疫学和转录组学特征的影响
  • 批准号:
    10183118
  • 财政年份:
    2017
  • 资助金额:
    $ 25.49万
  • 项目类别:
Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
研究维生素 D 对人 CD4 T c 中 FOXP3 和 IL-17 表达的影响
  • 批准号:
    7938575
  • 财政年份:
    2009
  • 资助金额:
    $ 25.49万
  • 项目类别:
Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
研究维生素 D 对人 CD4 T c 中 FOXP3 和 IL-17 表达的影响
  • 批准号:
    7706357
  • 财政年份:
    2009
  • 资助金额:
    $ 25.49万
  • 项目类别:

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定义实验性 AD 和 Tau 病中 MHC I 类限制性抗原呈递至 CD8 T 细胞 - 补充
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