Structural Biology/Proteomics Core

结构生物学核心将提供结构生物学，蛋白质分析和基于结构的 为许多SERCEB项目提供药物设计支持。支持将包括使用UAB的 新型高通量X射线晶体学能力、建模和结构生物信息学 服务，质谱加上生物量热法和结构热力学，以支持 提出了基于结构的药物设计工作。生物物理科学中心和 工程（UAB）由130名工作人员组成（20 l'h。1）。晶体学家）与建立，新颖的 在结晶筛选策略、纳米晶化、x射线数据收集方面的能力， 专用同步加速器访问和半自动结构测定。杜克大学和 行业合作者将提供高通量筛选技术， 使用先进的表面等离子体共振和基于抗体的 蛋白质微阵列设备。

The structural biology core will provide structural biology, protein profiling and structurebased drug design support for many of the SERCEB programs. Support will include use of UAB's novel, high-throughput x-ray crystallographic capabilities, modeling and structural bioinformatic services, mass spectroscopy plus biocalorimetry and structural thermodynamics in support of proposed structure-based drug design efforts. The Center for Biophysical Sciences and Engineering (UAB)is composed of 130 staff (20 l'h. 1). crystallographers) with established, novel capabilities in crystallization screening strategies, nanocrystallization, x-ray data collection including dedicated synchrotron access, and semi-automated structure determinations. Duke University and industry collaborators will provide high throughput screening technologies for protein-protein interactions and protein profiling using advanced surface plasmon resonance and antibody-based protein microarray facilities.