Structural Biology/Proteomics Core

结构生物学/蛋白质组学核心

• 批准号: 7656439
• 负责人: Lawrence J Delucas
• 金额: $ 28.4万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-15 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7656439
• 关键词: Aloral; Antibodies; Back; Binding; Bioinformatics; Biological; Charge; Complex; Crystallization; DNA; DNA-Directed DNA Polymerase; Data Collection; Drug Delivery Systems; Drug Design; Engineering; Growth; Industry Collaborators; Lead; Ligand Binding; Mass Spectrum Analysis; Membrane Proteins; Molecular Conformation; Orthopoxvirus; Pharmaceutical Preparations; Production; Protease Inhibitor; Protein Microchips; Proteins; Proteomics; Rate; Research Personnel; Resources; Science; Screening procedure; Services; Solutions; Structural Models; Structural Protein; Structure; Surface Plasmon Resonance; Synchrotrons; Taxes; Technology; Therapeutic; Thermodynamics; Universities; Uracil; Vaccines; Yersinia pestis; base; high throughput screening; member; novel; numb protein; programs; prospective; protein expression; protein protein interaction; structural biology; success; tool

The structural biology core will provide structural biology, protein profiling and structurebased drug design support for many of the SERCEB programs. Support will include use of UAB's novel, high-throughput x-ray crystallographic capabilities, modeling and structural bioinformatic services, mass spectroscopy plus biocalorimetry and structural thermodynamics in support of proposed structure-based drug design efforts. The Center for Biophysical Sciences and Engineering (UAB)is composed of 130 staff (20 l'h. 1). crystallographers) with established, novel capabilities in crystallization screening strategies, nanocrystallization, x-ray data collection including dedicated synchrotron access, and semi-automated structure determinations. Duke University and industry collaborators will provide high throughput screening technologies for protein-protein interactions and protein profiling using advanced surface plasmon resonance and antibody-based protein microarray facilities.

结构生物学核心将提供结构生物学，蛋白质分析和结构为基础