Structural Biology/Proteomics Core

结构生物学核心将提供结构生物学，蛋白质分析和结构为基础

The structural biology core will provide structural biology, protein profiling and structurebased drug design support for many of the SERCEB programs. Support will include use of UAB's novel, high-throughput x-ray crystallographic capabilities, modeling and structural bioinformatic services, mass spectroscopy plus biocalorimetry and structural thermodynamics in support of proposed structure-based drug design efforts. The Center for Biophysical Sciences and Engineering (UAB)is composed of 130 staff (20 l'h. 1). crystallographers) with established, novel capabilities in crystallization screening strategies, nanocrystallization, x-ray data collection including dedicated synchrotron access, and semi-automated structure determinations. Duke University and industry collaborators will provide high throughput screening technologies for protein-protein interactions and protein profiling using advanced surface plasmon resonance and antibody-based protein microarray facilities.