Proteomics Core

蛋白质组学核心

• 批准号: 7706300
• 负责人: EROL E GULCICEK
• 金额: $ 26.17万
• 依托单位: WADSWORTH CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7706300
• 关键词: Affinity; Agreement; American; Amino Acids; Arts; Award; Basic Science; Biochemical; Biological; Biological Markers; Biomedical Research; Biotechnology; Charge; Clinical Research; Code; Complement; Consultations; Country; Custom; Cyclotrons; Data Analyses; Disease Marker; Doctor of Philosophy; Electronic Mail; Emergency Situation; Environment; Equipment; Fee-for-Service Plans; Fluorescence; Foundations; Fourier Transform; Genome; Grant; Informatics; Institution; Ions; Isotopes; Laboratories; Mass Spectrum Analysis; Modeling; New England; Numbers; Other Resources; Peptide Synthesis; Peptides; Phosphoproteins; Plasma; Price; Protein Chemistry; Proteins; Proteomics; Range; Research; Research Personnel; Resources; Sampling; Services; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; System; Time; Universities; Wages; base; cost; design; experience; foot; gel electrophoresis; instrument; instrumentation; medical schools; member; pathogen; pre-clinical; programs; protein expression; tool

The Proteomics Core (PC) will be located within the Keck Laboratory at Yale University. It will provide a very broad range of mass spectrometry; protein chemistry, sequencing, and profiling; and peptide synthesis expertise and analytical capabilities to support basic science, preclinical and clinical research programs in each of the themes. Investigators will access PC services according to a subsidized fee-for-service agreement whereby the requested PC salary support will partially offset Keck service charges. Additionally, salary support will enable PC staff to go beyond the very defined services that are the hallmark of the Keck Lab. Hence, PC staff will be able to provide extensive consultation, more detailed data analysis and will be able to modify existing biotechnologies to meet the specialized needs of NBC members - who will be given the same turn-around priority as Yale investigators. In periods of emergency the PC would devote all of its considerable resources to meeting the challenge. NBC members will access analytical services by email or FAX submission of request for service forms and via overnight shipment of samples. With 44 staff, including 11 with Ph.D. and 6 with M.S. level degrees, and 74 major instruments purchased at a cost of $6.6 million dollars, the Keck Laboratory is one of the most advanced academic biotechnology laboratories in the world. By July, 2003 it will occupy 20,000 square feet. In 2001 the Keck Lab provided 146,612 services to 375 Yale and 767 non-Yale investigators at 189 institutions in 20 countries. As judged by extensive use of the Keck Laboratory by non-Yale investigators and by Study Panel reviews of its 17 NIH/NSF equipment grants, which often refer to this unit in words like, "The Keck Foundation Biotechnology Resource Laboratory at Yale is the premier biotechnology resource center in the world and is a model for such facilities on a scale that most universities cannot even contemplate", the Keck Lab will provide a unique environment in which to locate the PC. Hence, the PC will draw on the state-of-the-art instrumentation and the most experienced and senior staff within the proteomic resources of the Keck Laboratory.

蛋白质组学核心（PC）将位于耶鲁大学的凯克实验室。它将提供一个 非常广泛的质谱分析;蛋白质化学、测序和分析;以及肽合成 专业知识和分析能力，以支持基础科学，临床前和临床研究计划， 每个主题。研究者将根据补贴的服务费获得PC服务 根据该协议，所要求的PC工资支持将部分抵消凯克服务费。此外，本发明还 工资支持将使PC员工能够超越作为Keck标志的非常明确的服务 实验室因此，PC工作人员将能够提供广泛的咨询，更详细的数据分析， 能够修改现有的生物技术，以满足NBC成员的特殊需要-谁将被赋予 和耶鲁的调查员一样优先扭转局面在紧急情况下，PC将投入其所有 有足够的资源来应对挑战。NBC会员将通过电子邮件或 通过传真提交服务申请表，并通过隔夜装运样品。 员工44人，其中博士11人。6例多发性硬化症。水平学位，并购买了74个主要仪器 耗资660万美元的凯克实验室是世界上最先进的学术生物技术之一， 世界上的实验室到2003年7月，它将占地20，000平方英尺。2001年，凯克实验室提供了 为20个国家的189个机构的375名耶鲁大学和767名非耶鲁大学研究人员提供了146，612项服务。评选出了媒体 通过广泛使用凯克实验室的非耶鲁大学的研究人员和研究小组审查其17 NIH/NSF设备赠款，通常用“凯克基金会生物技术”这样的词来指代这个单位 耶鲁大学资源实验室是世界上首屈一指的生物技术资源中心， 这种规模的设施，大多数大学甚至无法想象”，凯克实验室将提供一个独特的 环境中找到PC。因此，PC将利用最先进的仪器， 凯克实验室蛋白质组学资源中最有经验和最资深的工作人员。