Pulmonary Infection & Inflammation

肺部感染和炎症核心的总体目标是提供小动物气雾剂 支持RCE的研究、职业发展和发展项目的挑战模型。 这个核心汇集了在研究分子和细胞生物学方面具有丰富经验的科学家。 在正常和遗传改变的肺中使用气溶胶激发模型的免疫学和病理学 动物核心将提供最先进的技术支持、设施和协作专业知识。 核心的具体目标是： 1.提供适用于将小鼠、大鼠、豚鼠或家兔暴露于 由活菌、脂多糖、抗原蛋白或免疫调节剂组成的气溶胶。 2.向研究者提供气雾剂激发后特定时间点采集的标本， 允许研究细菌和宿主对感染或炎症刺激的反应。 3.提供这些组织中采集的组织标本的组织病理学和多重蛋白质分析 在RCE研究人员进行的实验和其他研究中，以便于研究 肺部的炎症和免疫反应

The overall objective of the Pulmonary Infection and Inflammation Core is to provide small animal aerosol challenge models that support the research, career development, and developmental projects of the RCE. This Core brings together scientists with extensive experience in studying the molecular and cellular immunology and pathology of the lungs using aerosol challenge models in normal and genetically altered animals. The Core will provide state-of-the-art technical support, facilities, and collaborative expertise. The Specific Aims of the Core are to: 1. Provide aerosol challenge systems suitable for exposing mice, rats, guinea pigs, or rabbits to aerosols composed of live bacteria, lipopolysaccharide, antigenic proteins, or immunomodulators. 2. Provide investigators with specimens harvested at specific time points after aerosol challenge to permit study of bacterial and host responses to the infection or inflammatory stimulus. 3. Provide histopathologic and multiplex protein analyses of tissue specimens harvested in these experiments and in other studies performed by RCE investigators, to facilitate investigation of inflammatory and immune responses in the lungs.