课题基金 / 基金详情

Functional Heterogeneity of Pulmonary Arteries and Veins

Functional Heterogeneity of Pulmonary Arteries and Veins
肺动脉和静脉的功能异质性
批准号：
7684661
负责人：
J. Usha RAJ
金额：
$50.42万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
项目状态：
已结题
起止时间：
2003-09-22 至 2012-08-31
来源：
https://reporter.nih.gov/project-details/7684661
关键词：
ArteriesBiological PreservationBirthBiteBloodBlood VesselsCessation of lifeChronicCyclic GMPDataELK1 geneExposure toFetusFunctional disorderHeterogeneityHypoxiaLeadLungNewborn InfantOxygenPathway interactionsPersistent Fetal Circulation SyndromePhenotypePreventionPulmonary artery structureRegulationRelaxationResistanceRoleSerum Response FactorSignal TransductionSmooth MuscleVeinsVenousdeprivationfetalin uteromyocardinneonatal pulmonary hypertensionpreventprotein protein interactionresponserho

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中文摘要
翻译
描述(申请人提供)：出生时，肺部的动脉和静脉都必须放松，这样血液才能自由地流向肺部，它们才能正常运作，让宝宝变得粉红色。如果肺动脉不松弛，血液流入肺部的阻力仍然很高，血液从肺部分流，导致婴儿出生后保持蓝色。如果肺中的静脉不放松，肺部可能会变得非常潮湿。通过了解为什么胎儿慢性缺氧后肺动脉表现异常，以及为什么肺静脉功能略好，我们希望找到预防和治疗新生儿肺动脉高压的方法，这是一种可能导致新生儿死亡的疾病。
英文摘要
DESCRIPTION (provided by applicant): At birth, both the arteries and veins in the lungs must relax so that blood can flow freely to the lungs and they can function normally and get the baby to "pink up". If the lung arteries do not relax, the resistance for blood to flow into the lungs remains high and blood is diverted away from the lungs leading to the baby remaining blue after birth. If the veins in the lungs do not relax, the lungs can get very wet. By understanding why the lung arteries behave abnormally following chronic oxygen deprivation of the fetus, and why the lung veins function a bit better, we hope to find means of prevention and treatment of Pulmonary Hypertension of the Newborn, a condition that can lead to death of the newborn.
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