课题基金 / 基金详情

Functional Heterogeneity of Pulmonary Arteries and Veins

Functional Heterogeneity of Pulmonary Arteries and Veins
肺动脉和静脉的功能异质性
批准号：
7920889
负责人：
J. Usha RAJ
金额：
$50.89万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
项目状态：
已结题
起止时间：
2003-09-22 至 2012-08-31
来源：
https://reporter.nih.gov/project-details/7920889
关键词：
ArteriesBiological PreservationBirthBiteBloodBlood VesselsCessation of lifeChronicCyclic GMPDataELK1 geneExposure toFetusFunctional disorderHeterogeneityHypoxiaLeadLungNewborn InfantOxygenPathway interactionsPersistent Fetal Circulation SyndromePhenotypePreventionPulmonary artery structureRegulationRelaxationResistanceRoleSerum Response FactorSignal TransductionSmooth MuscleVeinsVenousdeprivationfetalin uteromyocardinneonatal pulmonary hypertensionpreventprotein protein interactionresponserho

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相关文献

中文摘要
翻译
描述（由申请人提供）：出生时，肺部的动脉和静脉都必须放松，这样血液才能自由地流向肺部，它们才能正常工作，让婴儿“粉红”。如果肺部动脉不放松，血液流入肺部的阻力仍然很大，血液就会从肺部转移出去，导致婴儿出生后仍然是蓝色的。如果肺里的静脉不放松，肺就会变得很湿。通过了解为什么胎儿长期缺氧后肺部动脉表现异常，以及为什么肺静脉功能稍好一些，我们希望找到预防和治疗新生儿肺动脉高压的方法，这是一种可能导致新生儿死亡的疾病。
英文摘要
DESCRIPTION (provided by applicant): At birth, both the arteries and veins in the lungs must relax so that blood can flow freely to the lungs and they can function normally and get the baby to "pink up". If the lung arteries do not relax, the resistance for blood to flow into the lungs remains high and blood is diverted away from the lungs leading to the baby remaining blue after birth. If the veins in the lungs do not relax, the lungs can get very wet. By understanding why the lung arteries behave abnormally following chronic oxygen deprivation of the fetus, and why the lung veins function a bit better, we hope to find means of prevention and treatment of Pulmonary Hypertension of the Newborn, a condition that can lead to death of the newborn.
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