课题基金 / 基金详情

Functional Heterogeneity of Pulmonary Arteries and Veins

Functional Heterogeneity of Pulmonary Arteries and Veins
肺动脉和静脉的功能异质性
批准号：
7475293
负责人：
J. Usha RAJ
金额：
$48.95万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
项目状态：
已结题
起止时间：
2003-09-22 至 2012-08-31
来源：
https://reporter.nih.gov/project-details/7475293
关键词：
ArteriesBiological PreservationBirthBiteBloodBlood VesselsCessation of lifeChronicConditionCyclic GMPDataELK1 geneExposure toFetusFunctional disorderHeterogeneityHypoxiaLeadLungNewborn InfantOxygenPathway interactionsPersistent Fetal Circulation SyndromePhenotypePreventionPulmonary artery structureRegulationRelaxationResistanceRoleSerum Response FactorSignal TransductionSmooth MuscleVeinsVenousdeprivationfetalin uteromouse Smc1l1 proteinmouse Smc1l2 proteinmyocardinneonatal pulmonary hypertensionpreventprotein protein interactionresponserho

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相关文献

中文摘要
翻译
描述（由申请人提供）：出生时，肺部的动脉和静脉都必须放松，这样血液才能自由地流向肺部，它们才能正常工作，让婴儿“粉红色”。如果肺动脉不放松，血液流入肺部的阻力仍然很高，血液从肺部转移，导致婴儿出生后仍然是蓝色的。如果肺中的静脉不放松，肺会变得非常潮湿。通过了解为什么肺动脉在胎儿慢性缺氧后表现异常，以及为什么肺静脉功能更好，我们希望找到预防和治疗新生儿肺动脉高压的方法，这种情况可能导致新生儿死亡。
英文摘要
DESCRIPTION (provided by applicant): At birth, both the arteries and veins in the lungs must relax so that blood can flow freely to the lungs and they can function normally and get the baby to "pink up". If the lung arteries do not relax, the resistance for blood to flow into the lungs remains high and blood is diverted away from the lungs leading to the baby remaining blue after birth. If the veins in the lungs do not relax, the lungs can get very wet. By understanding why the lung arteries behave abnormally following chronic oxygen deprivation of the fetus, and why the lung veins function a bit better, we hope to find means of prevention and treatment of Pulmonary Hypertension of the Newborn, a condition that can lead to death of the newborn.
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