Longitudinal trends in alcohol use and AUDs among rural stimulant users

农村兴奋剂使用者酒精使用和澳元的纵向趋势

• 批准号: 7739876
• 负责人: Tyrone Finley Borders
• 金额: $ 7.25万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-10 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7739876
• 关键词: Address; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohols; Americas; Cocaine; Cocaine Users; Communities; Complement; Cross-Sectional Studies; Data; Data Analyses; Data Set; Development; Diagnosis; Disease remission; Drug abuse; Drug usage; Drug user; Enrollment; Epidemiology; Frequencies; Funding; Goals; Grant; Growth; Guidelines; Human Resources; Illicit Drugs; Interview; Intoxication; Knowledge; Literature; Longitudinal Studies; Maintenance; Measures; Methamphetamine; Modeling; NIH Program Announcements; National Institute of Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; Natural History; Nature; Parents; Participant; Pattern; Persons; Public Health; Research; Risk; Rural; Sampling; Services; Substance Use Disorder; Substance abuse problem; Surveys; Testing; Time; Time Study; alcohol epidemiology; alcohol use disorder; base; cocaine use; cost effective; deter alcohol use; drinking; experience; falls; member; public health relevance; response; rural area; substance abuse prevention; treatment program; trend

DESCRIPTION (provided by applicant): This application is in response to the NIAAA program announcement (PA-08-169) on Secondary Analysis of Existing Alcohol Epidemiology Data. The overarching goal of this application is to enhance our understanding of the longitudinal patterns and trends of alcohol use among methamphetamine and cocaine users. Most prior research on the epidemiology of alcohol and stimulant use has relied on data from cross-sectional surveys or treatment-based samples. There is very little information about the natural history of alcohol use among community-based samples of stimulant users, particularly methamphetamine users, many of whom do not access formal substance abuse services. Of key concern is whether alcohol is used a complement or substitute to cocaine and/or methamphetamine over time and whether cocaine and/or methamphetamine use is associated with the risk of developing/maintaining or remitting from an alcohol use disorder (AUD). To address these issues, we propose to conduct extensive secondary statistical analyses of alcohol-related data collected as part of the NIDA-funded Rural Stimulant Study (RSS). The RSS is a very unique multi-state, community-based, and longitudinal (7 interviews over 3 years) natural history study of 710 persons who were recent or current users of cocaine and/or methamphetamine at the time of study enrollment. While numerous measures of the frequency and quantity of alcohol use as well as diagnoses of alcohol use disorders (AUDs) were assessed at 6-month intervals as part of the RSS, the original grant did not contain any specific aims or hypotheses pertaining to alcohol. Our specific research aims are to (1) Investigate the natural history of alcohol use and potential substitution of cocaine and/or methamphetamine with alcohol over time and (2) Investigate the longitudinal relationships between cocaine and MA use and the risk of an alcohol use disorder (AUD). We have chosen to focus this R03 application on these aims because they represent important unanswered questions and do not fall within the aims of the original parent study. An additional strength of the proposed study is that the sample is comprised of stimulant users residing in rural areas, a subpopulation that is historically understudied and underrepresented in substance abuse research. In summary, the proposed study will afford us the opportunity to conduct quantitative analyses of a unique data set and thus advance our understanding of the longitudinal interplay between alcohol and stimulant use in a very cost effective manner. The research findings have the potential to contribute to improvements in alcohol use prevention and treatment among current or past stimulant users. PUBLIC HEALTH RELEVANCE: The proposed research has important public health significance regarding alcohol and stimulant use, particularly in rural America, which is experiencing a rapid increase in the use of cocaine and methamphetamine. Further understanding of the interplay between alcohol and stimulant use over time, including whether alcohol is used as a substitute for cocaine and/or methamphetamine, could contribute to improvements in substance abuse prevention and treatment.

描述（由申请人提供）：本申请是对NIAAA计划公告（PA-08-169）关于现有酒精流行病学数据二次分析的回应。该应用程序的首要目标是加强我们对甲基苯丙胺和可卡因使用者中酒精使用的纵向模式和趋势的了解。大多数关于酒精和兴奋剂使用的流行病学研究都依赖于横断面调查或基于治疗的样本的数据。在社区抽样的兴奋剂使用者，特别是甲基苯丙胺使用者中，关于酒精使用自然史的信息很少，其中许多人没有获得正式的药物滥用服务。关键的问题是，随着时间的推移，酒精是否被用作可卡因和/或甲基苯丙胺的补充或替代品，以及可卡因和/或甲基苯丙胺的使用是否与酒精使用障碍（AUD）的发展/维持或缓解风险相关。为了解决这些问题，我们建议对作为NIDA资助的农村兴奋剂研究（RSS）的一部分收集的酒精相关数据进行广泛的二次统计分析。RSS是一项非常独特的多州、以社区为基础的纵向（3年7次访谈）自然史研究，纳入了710名在研究入组时最近或目前使用可卡因和/或甲基苯丙胺的人。虽然作为RSS的一部分，每隔6个月对酒精使用频率和数量以及酒精使用障碍（AUD）的诊断进行了评估，但最初的拨款并不包含任何与酒精有关的特定目标或假设。我们的具体研究目的是（1）调查酒精使用的自然史以及可卡因和/或甲基苯丙胺随时间推移而被酒精替代的可能性;（2）调查可卡因和MA使用与酒精使用障碍（AUD）风险之间的纵向关系。我们选择将R 03申请集中在这些目标上，因为它们代表了重要的未回答的问题，并且不属于原始母研究的目标范围。拟议研究的另一个优点是，样本由居住在农村地区的兴奋剂使用者组成，这是一个在药物滥用研究中历来研究不足和代表性不足的亚群。总之，拟议的研究将为我们提供机会，进行定量分析的一个独特的数据集，从而提高我们的理解之间的纵向相互作用的酒精和兴奋剂的使用在一个非常具有成本效益的方式。研究结果有可能有助于改善目前或过去的兴奋剂使用者的酒精使用预防和治疗。公共卫生关系：拟议的研究对酒精和兴奋剂的使用具有重要的公共卫生意义，特别是在美国农村，那里正在经历可卡因和甲基苯丙胺使用的快速增长。随着时间的推移，进一步了解酒精和兴奋剂使用之间的相互作用，包括酒精是否被用作可卡因和（或）甲基苯丙胺的替代品，可有助于改进药物滥用的预防和治疗。