Small Animal Image-Guided Radiotherapy

小动物影像引导放射治疗

• 批准号: 7585172
• 负责人: EDWARD E GRAVES
• 金额: $ 32.79万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-10 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7585172
• 关键词: Animal Disease Models; Animals; Biomedical Research; Cancer Model; Clinic; Clinical; Clinical Management; Clinical Medicine; Clinical Trials Design; Collimator; Communities; Computer software; Conformal Radiotherapy; Data; Development; Devices; Dose; Dose Fractionation; Environment; Ethics; Evaluation; Experimental Models; Fractionation; Generations; Goals; Histological Techniques; Human; Hypoxia; Image; Imaging Techniques; In Situ; Individual; Investigation; Laboratories; Laboratory Animals; Lung; Malignant Neoplasms; Malignant neoplasm of pancreas; Methods; Modeling; Molecular Biology; Monitor; Mus; Positron-Emission Tomography; Procedures; Protocols documentation; Radiation; Radiation therapy; Radiobiology; Research; Residual state; Resistance; Roentgen Rays; Scheme; Small Animal Imaging Systems; Solutions; System; Techniques; Technology; Testing; Therapeutic; Tissues; Translations; Treatment Protocols; Uncertainty; Ursidae Family; Width; base; clinically relevant; comparative efficacy; cost; image guided therapy; imaging modality; improved; molecular imaging; new technology; novel; novel strategies; pancreatic neoplasm; response; treatment planning; tumor

DESCRIPTION (provided by applicant): The goal of this proposal is to implement and evaluate a full-featured solution for image-guided radiotherapy (IGRT) of small animals based on a microCT scanner. At present, the methods used to irradiate animal models of disease bear little resemblance to those routinely applied in the clinic. Through the development of radiotherapy techniques for small animals that approach the capabilities of clinical procedures, we will enable investigation of a variety of research questions relevant to clinical medicine as well as molecular biology. The feasibility of laboratory-based conformal radiotherapy has been demonstrated by preliminary investigations in my laboratory in which a variable aperture collimator has been added to a commercially available microCT system, generating a system capable of delivering radially convergent X-ray beams with circular profiles of arbitrary sizes to small animal subjects. In this project we will apply this novel technology towards the creation, evaluation, and preliminary application of a comprehensive method for imaging, treatment planning, and radiation delivery to small animals. Because this system will be developed as a hardware and software expansion for a commercial microCT scanner, it has the potential to be applied in biomedical research at a number of centers throughout the world at low cost. After generation of the system we will apply it in the study of radiotherapy in the treatment of orthotopic models of cancer, allowing evaluation of emerging therapeutic paradigms in a laboratory environment. These efforts will establish a new mechanism for exploring radiotherapy and radiobiology in the laboratory and will provide direct evidence of the merit of novel treatment regimens for use in designing clinical trials. In this research a system for treating small animals with clinically-similar image-guided conformal radiotherapy will be developed. The device, based on a commercially available microCT scanner, has the potential for widespread distribution and use within the scientific community, and will enable research of novel clinically- relevant radiation therapies and radiobiology in a laboratory. This research theme will be explored in this project by applying the system towards studying hypo- and hyper-fractionation schemes as well as hypoxia image-guided radiotherapy, providing data for subsequent clinical translation.

描述（由申请人提供）：本提案的目标是实施和评估基于microCT扫描仪的小动物图像引导放射治疗（IGRT）的全功能解决方案。目前，用于照射疾病动物模型的方法与临床上常规应用的方法几乎没有相似之处。通过开发接近临床程序能力的小动物放射治疗技术，我们将能够调查与临床医学以及分子生物学相关的各种研究问题。基于实验室的适形放射治疗的可行性已被证明在我的实验室，其中可变孔径准直器已被添加到市售的microCT系统的初步调查，产生一个系统能够提供径向收敛的X射线束与任意大小的圆形轮廓的小动物受试者。在这个项目中，我们将应用这种新技术来创建，评估和初步应用一种全面的方法，用于成像，治疗计划和对小动物的放射治疗。由于该系统将作为商用microCT扫描仪的硬件和软件扩展开发，因此它有可能以低成本应用于世界各地许多中心的生物医学研究。在生成该系统后，我们将其应用于原位癌症模型治疗中的放射治疗研究，从而可以在实验室环境中评估新兴的治疗模式。这些努力将建立一个新的机制，在实验室中探索放射治疗和放射生物学，并将提供直接的证据，用于设计临床试验的新的治疗方案的优点。在本研究中，将开发一种用于治疗小动物的具有临床相似性的图像引导适形放射治疗系统。该设备基于市售microCT扫描仪，具有在科学界广泛分发和使用的潜力，并将使实验室中的新型临床相关放射疗法和放射生物学研究成为可能。本研究课题将通过应用该系统研究低分割和高分割方案以及低氧图像引导放射治疗来探索，为后续临床翻译提供数据。