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Small Animal Radiation Research Platform @ Stanford

斯坦福小动物辐射研究平台

基本信息

批准号：
8640371
负责人：
EDWARD E GRAVES
金额：
$ 59.98万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-05-15 至 2016-01-14
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Stanford University is recognized as a leader in the development and study of radiation therapy, from the first use of the medical linear accelerator in 1955 to the understanding of the influence of tumor hypoxia on therapeutic response in the 1970's and 1980's to the development of intensity-modulated radiation therapy in the 1990's to the ongoing development of image-guided radiation therapy. However, Stanford lacks a system for delivering radiotherapy to small animals with the conformality and image guidance routinely achieved in the clinic. We therefore request funds to purchase a Small Animal Radiation Research Platform (SARRP) from XStrahl. The SARRP is a compact irradiator employing a 225 kVp x-ray beam mounted on a rotating frame, capable of delivering beams from multiple angles and incorporating collimators to shape the beam. In addition, the SARRP can acquire and reconstruct cone beam x-ray computed tomography data, facilitating the use of volumetric imaging to guide radiation therapy. This system will be employed by a cohesive set of core users spanning multiple departments (Radiation Oncology, Radiology, Pediatrics, Medicine) and research interests (tumor and normal tissue radiobiology, stem cells, and technology development). The PI has a track record in the development of small animal radiotherapy systems and has assembled a team to deploy and manage this device within the Stanford research environment. With this new technology we will significantly enhance the translational potential of NIH funded research and will develop new science and technology.

描述(申请人提供)：斯坦福大学是公认的放射治疗的发展和研究的领导者，从1955年首次使用医用直线加速器，到1970年的S和1980年的S对肿瘤缺氧对治疗反应的影响的了解，到1990年的S的调强放射治疗的发展，再到图像引导放射治疗的不断发展。然而，斯坦福大学缺乏一种向小动物提供放射治疗的系统，而这种系统通常在临床上实现一致性和图像引导。因此，我们请求资金从Xstrahl购买一个小动物辐射研究平台(SARRP)。SARRP是一种紧凑型辐照器，采用安装在旋转框架上的225千伏X射线束，能够从多个角度发射光束，并结合准直器来整形光束。此外，SARRP还可以获取和重建锥束X射线计算机断层扫描数据，便于使用体积成像来指导放射治疗。该系统将被多个部门(放射肿瘤学、放射学、儿科、内科)和研究兴趣(肿瘤和正常组织放射生物学、干细胞和技术开发)的核心用户集合使用。PI在开发小动物放射治疗系统方面有着良好的记录，并组建了一个团队在斯坦福大学的研究环境中部署和管理这种设备。有了这项新技术，我们将大大增强NIH资助的研究的翻译潜力，并将开发新的科学和技术。