Novel MRI and 1H-MRS markers in Primary Progressive MS

四页) 其他传记小品(每份不超过四页-见说明书) 资源33 研究计划。33 修订申请简介(不超过3页)33 补充申请简介(不超过一页)N/A A.具体目标36 B.背景和意义37 C.初步研究/进度报告/(项目A-D：不超过25页*)44 第一阶段进度报告(仅限于SBIR/STTR第二阶段)*SBIR/STTR第一阶段：项目A-D，限于15页。 D.研究设计和方法50 E.人体受试者58 保护人类受试者(如正面第4项标记为“是”，则为必填项)58 包括妇女(如正面第4项标记为“是”，则为必填项)_58 包括少数族裔(如首页第4项标记为“是”，则为必填项)_58 包括儿童(如首页第4项标记为“是”，则为必填项)58 数据和安全监测计划(如果页面上的第4项标记为是且为I、II或III期临床，则为必填项 建议进行试验 F.脊椎动物60 G.引用文献60篇 H.联合体/合同安排66 一、支持函(如顾问)68 J.产品开发计划(仅限SBIR/STTR第二阶段和快速通道)N/A 核对表。69 检查是否 附录(五个整理集。附录中不需要编号。) 附录为 包括在内 除非特别请求，否则第一阶段SBIR/STTR不允许使用附录... 接受出版的出版物和稿件数量(注：超过10篇) 其他项目(列表)： 支持函：约翰·德卢卡教授，顾问 小灵通398(05/01版)页表单第3页 使用/2英寸页边距。在整个应用程序的底部连续编号页码。不要使用3a、3b等后缀。

four pages) Other Biographical Sketches (Not to exceed four pages for each - Seeinstructions) Resources 33 Research Plan. 33 Introduction to Revised Application (Not to exceed 3 pages) 33 Introduction to Supplemental Application (Not to exceed one page) N/A A. Specific Aims 36 B. Background and Significance 37 C. Preliminary Studies/Progress Report/ (Items A-D: not to exceed 25 pages*) 44 Phase I Progress Report (SBIR/STTR Phase II ONLY) * SBIR/STTR Phase I: Items A-D limited to 15 pages. D. Research Design and Methods 50 E. Human Subjects 58 Protection of Human Subjects (Required if Item 4 on the Face Page is marked "Yes") 58 Inclusion of Women (Required if Item 4 on the Face Page is marked "Yes") _58 Inclusion of Minorities (Required if Item 4 on the Face Page is marked "Yes") _58 Inclusion of Children (Required if Item 4 on the Face Page is marked "Yes") 58 Data and Safety Monitoring Plan (Required if Item 4 on the Face Page is marked "Yes" and a Phase I, II, or III clinical trial is proposed F. Vertebrate Animals 60 G. Literature Cited 60 H. Consortium/Contractual Arrangements 66 I. Letters of Support (e.g., Consultants) 68 J. Product Development Plan (SBIR/STTR Phase II and Fast-Track ONLY) N/A Checklist. 69 Check if Appendix (Five collatedsets. Nopage numbering necessary for Appendix.) Appendix is Included Appendices NOT PERMITTED for Phase I SBIR/STTR unless specifically solicited.... Number of publications and manuscripts accepted for publication (notto exceed10) Other items (list): 1. Letter of support: Prof. John DeLuca, consultant PHS 398 (Rev. 05/01) Page. Form Page 3 Use /2-inch MARGINS. Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b.