Novel MRI and 1H-MRS markers in Primary Progressive MS

原发性进展型多发性硬化症中的新型 MRI 和 1H-MRS 标记物

• 批准号: 8259346
• 负责人: Matilde INGLESE
• 金额: $ 9万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8259346
• 关键词: Novel; MRI; 1H; MRS; markers

four pages) Other Biographical Sketches (Not to exceed four pages for each - Seeinstructions) Resources 33 Research Plan. 33 Introduction to Revised Application (Not to exceed 3 pages) 33 Introduction to Supplemental Application (Not to exceed one page) N/A A. Specific Aims 36 B. Background and Significance 37 C. Preliminary Studies/Progress Report/ (Items A-D: not to exceed 25 pages*) 44 Phase I Progress Report (SBIR/STTR Phase II ONLY) * SBIR/STTR Phase I: Items A-D limited to 15 pages. D. Research Design and Methods 50 E. Human Subjects 58 Protection of Human Subjects (Required if Item 4 on the Face Page is marked "Yes") 58 Inclusion of Women (Required if Item 4 on the Face Page is marked "Yes") _58 Inclusion of Minorities (Required if Item 4 on the Face Page is marked "Yes") _58 Inclusion of Children (Required if Item 4 on the Face Page is marked "Yes") 58 Data and Safety Monitoring Plan (Required if Item 4 on the Face Page is marked "Yes" and a Phase I, II, or III clinical trial is proposed F. Vertebrate Animals 60 G. Literature Cited 60 H. Consortium/Contractual Arrangements 66 I. Letters of Support (e.g., Consultants) 68 J. Product Development Plan (SBIR/STTR Phase II and Fast-Track ONLY) N/A Checklist. 69 Check if Appendix (Five collatedsets. Nopage numbering necessary for Appendix.) Appendix is Included Appendices NOT PERMITTED for Phase I SBIR/STTR unless specifically solicited.... Number of publications and manuscripts accepted for publication (notto exceed10) Other items (list): 1. Letter of support: Prof. John DeLuca, consultant PHS 398 (Rev. 05/01) Page. Form Page 3 Use /2-inch MARGINS. Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b.

四页)

项目成果

Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T.

通过 9.4 T 的磁化转移成像监测小鼠大脑中的脱髓鞘和髓鞘再生。

• DOI: 10.1007/s10334-008-0141-3
• 发表时间: 2008
• 期刊: Magma (New York, N.Y.)
• 作者: Zaaraoui,Wafaa;Deloire,Mathilde;Merle,Michel;Girard,Céline;Raffard,Gérard;Biran,Marc;Inglese,Matilde;Petry,KlausG;Gonen,Oded;Brochet,Bruno;Franconi,Jean-Michel;Dousset,Vincent
• 通讯作者: Dousset,Vincent